University of the Witwatersrand

An evaluation of denecimig for bleeding prophylaxis in hemophilia A

Introduction Despite advances in factor VIII (FVIII) replacement and emicizumab prophylaxis, people with hemophilia A may experience breakthrough bleeding, progressive joint disease, treatment burden, and inhibitor-related limitations. Denecimig (Mim8) is a fully human, next-gene...

Not speaking my language: playback experiments reveal early-orphaned human-reared adult cheetahs lack interest in species-specific vocalizations

Abstract Early adult models, particularly the mother, play an essential role in tuning perception to build the multimodal representation of species-specific social signals, especially in mammals. Therefore, early maternal loss adversely impacts social integration in mammals. More...

Into the woods of ancient Corinth: wood charcoal analysis & human-woodland associations in Hellenistic and early Roman Greece

This paper explores the historical periods of Hellenistic and Early Roman Greece, which brought important changes to the region during the second half of the 1st millennium BCE. While these periods hold great historical and cultural importance, the understanding of how individual...

Untargeted metabolomics reveals chemical variation and antimicrobial biomarkers in Dodonaea viscosa var. angustifolia (L.f.) Benth

Dodonaea viscosa var. angustifolia (L.f.) Benth is a widely used medicinal plant with reported biological activities, however few studies have identified marker compounds for quality control of the plant and interspecies chemical variation. The aim of this study was to investigat...

Anxiety and Depressive Symptoms among Undergraduate Health Sciences Students at a Rural South African University: Prevalence and Multivariable Correlates

Introduction/Objective Health sciences students may experience substantial anxiety and depressive symptoms, yet evidence from rural South African faculties remains limited. This study estimated the prevalence and severity of anxiety and depressive symptoms and examined associated...

Targeting MAPK9 in neurodegenerative diseases: mechanistic insights, phytochemical modulators, and emerging computational approaches

The protein Mitogen-activated protein kinase 9 (MAPK9) (c-Jun N-terminal kinase 2 [JNK2]) is a critical signalling molecule involved in cellular survival, inflammation, oxidative stress, and the programming of cell death. This is because there has been emerging evidence of the ef...

Women's entrepreneurship and resilience: focusing on a Central European entrepreneurial setting

Purpose Despite extensive research on resilience in established organizations, scholarship intersecting entrepreneurial resilience and women's entrepreneurship has been slow to progress. Much of the academic discourse within this research stream often centres on women's negative...

Anatomy, histology, and histochemistry of the harderian and lacrimal glands in the great spotted woodpecker (dendrocopos major)

Abstract The Harderian and lacrimal glands are the main orbital glands of the avian lacrimal apparatus and contribute to the tear film, nictitating membrane function, and local protection of the ocular surface. Although the ocular adnexa have been well described in domestic birds...

Duration of Resuscitation and Survival of Pediatric Traumatic Cardiac Arrest

Objectives: To evaluate the association between resuscitation duration and survival from pediatric traumatic cardiac arrest (TCA). Methods: A meta-analysis was conducted. CENTRAL, MEDLINE, and EMBASE were searched from January 1, 2000, to January 31, 2026. Eligible studies includ...

Perspectives on adverse events reporting in hybrid implementation science (IS) clinical trials of approved medications in Sub-Saharan Africa

Implementation science (IS) hybrid type 2 and 3 clinical trials and pure implementation research of approved medications test strategies to increase uptake of evidence-based interventions (EBIs) with well-established safety profiles. Guidance on adverse event (AE) monitoring and...

Institutional drivers of sustainable development goals implementation in facilities management: evidence from South Africa

Purpose During the operational phase of buildings, facilities managers are uniquely positioned to implement sustainable development goals (SDGs) without expensive construction changes required. The ISO 41000 series of International facilities management (FM) standards provides hi...

Prenatal kolanut exposure suppresses hippocampal dentate gyrus neurogenesis in adolescent and young adult rats

Abstract Kolanut, a social delicacy for men and women, including pregnant women, in West African countries, and in sub-Saharan African continent contains caffeine, theobromide and tannins. This study investigated the possible adverse effects of kolanut following prenatal exposure...

Pneumococcal population structure influences the effects of air pollution on invasive disease risk in South Africa

Abstract Streptococcus pneumoniae is highly diverse, comprising over 100 serotypes and hundreds of genomic lineages amid widespread vaccination. While it can cause invasive pneumococcal disease (IPD) which exhibits pronounced seasonal spikes, the interplay between pneumococcal di...

Moorings: Voyages of Capital Across the Indian Ocean

This book examines the lifeworlds, voyages, and traversed geographies of two seafaring Muslim communities—Bhadalas and Waghers—from the port towns of Mota Salaya in Mandvi and Jam Salaya on the Gul...

Effects of heat exposure on self-reported heat strain symptoms among pregnant and postpartum women in South Africa

Abstract Heat exposure can harm pregnant and postpartum women, yet heat strain symptoms in this population remain underexplored. This study implemented a novel mobile application and assessed the environmental context of five self-reported heat strain symptoms: skin rashes, sleep...

The Smartphone as Celestial Tablet: Digital Semiotics, Non Local Consciousness, and the Modern Enochic Paradigm of After Death Communication

This article presents a five‑and‑a‑half‑year longitudinal phenomenological case study documenting structured visual experiences occurring in full waking consciousness following contemplative prayer after identical twin bereavement. The dataset exhibits two distinct phases: an ext...

The Smartphone as Celestial Tablet: Digital Semiotics, Non Local Consciousness, and the Modern Enochic Paradigm of After Death Communication

This article presents a five‑and‑a‑half‑year longitudinal phenomenological case study documenting structured visual experiences occurring in full waking consciousness following contemplative prayer after identical twin bereavement. The dataset exhibits two distinct phases: an ext...

Real Estate Insights: How agentic artificial intelligence could disrupt real estate?

Purpose The real estate industry has traditionally relied on conventional operating models that limit efficiency, transparency and strategic decision-making. This study explores how agentic Artificial intelligence (AI) could disrupt the real estate industry, its current and futur...

Improving the management of leprosy ulcers through a community self-care intervention using a stepped wedge cluster randomised trial in South-East Nigeria

Background Self-care is used to promote leprosy ulcer healing and reduce recurrence. RedAid Nigeria in South-East Nigeria adapted and implemented a recently developed international guideline for self-care of leprosy ulcers. We report a prospective, mixed methods evaluation of thi...

Theory–simulation–application framework to enhance biostatistical capacity for HIV and cancer data analysis in sub-Saharan Africa: lessons learnt from Tanzania

Enhancing biostatistical capacity in sub-Saharan Africa (SSA) is imperative for the efficient analysis of routinely collected health data and for clinical and public health decision-making. We describe the experiences and lessons learnt from implementing advanced statistical capa...