University of Southampton

RNA sequencing significantly improves HYDIN diagnosis and defines the effects of common deletions in primary ciliary dyskinesia

Abstract Primary Ciliary Dyskinesia (PCD) is a rare genetic disorder affecting ~1:7500 individuals characterised by recurrent chronic respiratory infections, bronchiectasis, laterality defects, and infertility. While at least 60 PCD-causing genes are reported, approximately 30% o...

Point/Counterpoint on the Controversial 2025–2030 Dietary Guidelines for Americans

The 2025-2030 Dietary Guidelines for Americans (DGAs) issued nutrition recommendations, some of which have been praised by the nutrition community while others have been questioned based on the lack of supporting evidence. The recommendations about calorie control, emphasis on nu...

Observation of a supersolid phase in a spin-orbit coupled exciton-polariton Bose-Einstein condensate

In Bose-Einstein condensates, spin-orbit coupling (SOC) produces supersolidity. It is a peculiar state of matter, which, in addition to the superfluid behavior, shows periodic density modulation typical for crystals. Here, we report the fabrication of an original type of optical...

Do textual attributes of management commentary matter for analyst coverage and information quality: evidence from the United Kingdom

Purpose This study examines whether the readability of management commentary is associated with analysts' coverage and the precision of analysts' information sets. It further investigates whether analysts' experience, access to resources and forecast boldness moderate these relat...

Measuring the rate of glitches in interferometric gravitational wave detectors with a hierarchical Bayesian model

Abstract Ground-based gravitational wave detectors are now routinely surveying the dark Universe, finding hundreds of collisions between compact objects. However, terrestrial non-Gaussian noise artefacts, commonly known as glitches, reduce the sensitivity to signals and can overl...

The next generation of maternal vaccines: scientific advances, regulatory readiness, and strategic planning in Europe

With the recent approval of maternal RSV vaccines and late-phase trials underway for a GBS vaccine, Europe is entering a new era of maternal immunisation. Yet scientific progress is outpacing pregnancy-specific evidence and preparedness for equitable implementation. Pregnant wome...

Economic evaluation protocol of the Ntshembo (Hope) Trial (RCT) in rural and urban South Africa: an intervention to optimise adolescence body mass index (BMI) pre-conception to address the triple burden of malnutrition

South African adolescent girls face a triple burden of malnutrition, undernutrition alongside overweight/obesity, and micronutrient deficiencies, heightened risk factors for Non-Communicable Diseases (NCDs). The Ntshembo trial is a South African Randomised Controlled Trial (RCT)...

Fast, Strong Capillary Liquid Metal Muscles

Harnessing liquid surface tension to perform mechanical work is widespread in nature and underpins many bioinspired technologies. However, fully exploiting liquid surface energy requires rapid, reversible, and wide‐range tuning of surface tension—capabilities lacking in conventio...

Numerical calculations of neutron star mountains supported by crustal lattice pressure

Abstract Gravitational waves may set the spin frequencies of neutron stars in low-mass X-ray binaries (LMXBs). One mechanism for facilitating such emission is the formation of a mass asymmetry - or ‘mountain’ - supported by elastic strains driven by thermal gradients. Most studie...

Super Warm Early Eocene Simulations With HadGEM3‐GC31‐LL

Abstract The early Eocene Climatic Optimum (EECO; 53.3–49.1 million years ago) represents the period of greatest sustained warmth in the Cenozoic (last 66 million years), with proxy‐data indicating global‐mean temperatures 10–16°C above preindustrial and atmospheric concentration...

How followers evaluate social media influencers’ communication: A persuasion‐based perspective and research agenda

Abstract Scholarly research on social media influencers is expanding. Although the field has grown substantially, its research base remains fragmented. This is largely due to the multitude of disciplines upon which influencer research draws and to the diverse perspectives applied...

Integrating Hyperuniform Disordered Light Trapping Layers in Ultrathin c-Si Solar Cells

Abstract Ultrathin crystalline silicon solar cells require advanced light trapping to compensate for weak near-infrared (NIR) absorption. Here, we integrate hyperuniform disordered light-engineered (HUDLE) nanopatterns with high-quality surface passivation in 4.8 μm c Si cells an...

Ancient terrestrial forests reborn as modern marine ecosystems under shifting sea levels

Abstract Sea-level rise and coastal erosion can submerge terrestrial carbon-rich landscapes, yet the ecological fate and climate significance of such relict coastal carbon deposits remain largely unknown. We report the discovery of submerged tropical peat reefs in the shallow coa...

Political trust and inheritance taxation: evidence from four studies

Inheritance (estate) taxation is a potentially powerful instrument for reducing inequality and raising state revenues, yet it attracts opposition well beyond the small minority who will ever pay it. We argue that political trust helps explain who supports it. Because the tax is l...

Enabling monocular collision avoidance in a smart hangar

Abstract Hangar-based maintenance, repair and overhaul (MRO) operations expose aircraft to close-proximity interactions with ground support equipment (GSE), where operator errors can cause structural damage and disruption. This study presents a monocular vision framework for coll...

The influence mechanism of firm green technology cooperation: a supply chain perspective with evidence from chinese cases

To address growing environmental challenges, focal firms are increasingly pursuing green technology cooperation within their supply chains. However, limited research has yet proposed a theoretical framework for green technology cooperation among firms from the perspective of supp...

Linking centromere stretch to SAC signaling in mammalian oocytes with insights from modified kinetochore model

Abstract The spindle assembly checkpoint (SAC) monitors kinetochore-microtubule interactions to ensure accurate chromosome segregation. In mitosis, investigation of its silencing at anaphase centers on whether attachment or tension is the key signal, while in meiosis for mammalia...

Intensification of near-inertial currents in the Atlantic Ocean over the past two decades

Near-inertial currents (NICs) play a key role in surface material redistribution and ocean mixing, yet their long-term variability remains poorly known. Using in situ current measurements from surface drifters, we provide observational evidence for a pronounced intensification of...

The Role of Performance Measurement in Managing Political‐Economic Tensions: A Case Study of Economic Value Added Adoption in a State‐Owned Enterprise

ABSTRACT This study examines how performance measurement systems (PMSs) mediate political‐economic tensions in Chinese state‐owned enterprises (SOEs), where state directives and market mechanisms coexist. Drawing on a longitudinal case study of a Chinese central SOE following the...

Optimising support for post-16 transition: young peoples’ perspectives on the barriers and contributors to a successful transition

In 2015, national policy in England raised the mandatory education participation age to 18, making the transition to post-16 education compulsory. Inadequate support at this transition milestone can lead to negative outcomes, including becoming NEET (Not in Education, Employment,...