University of Southampton

Strategic roadmap for delivery of clinical trials in rare childhood central nervous system (CNS) tumours: a multi-stakeholder consensus

Abstract Rare paediatric central nervous system (CNS) tumours comprise a biologically-heterogeneous group of low-incidence diseases that present significant challenges to both therapeutic development and clinical research, limiting the availability of high-quality evidence to gui...

P1.132. Assessing the Impact of Radiomics Features on Machine Learning Models for Predicting Multidisciplinary Treatment Decisions in Oesophageal Cancer

Abstract Topic Esophageal Cancer: Other Background Medical Artificial Intelligence (MAI) is expanding within surgical oncology with new tools emerging for assisting cancer multidisciplinary teams (MDTs) in cancer types such as oesophageal cancer (OC). Radiomics has similarly gain...

Monolithic Ge/SiGe quantum well photodetectors integrated with SiN waveguides on 200 mm silicon wafers

Abstract The rapid growth of data processing is driving an urgent need for high-speed, low-power transceivers to support compute and interconnect demands. Here, we demonstrate a monolithically integrated O-band Ge/SiGe quantum-confined Stark effect (QCSE) photodetector seamlessly...

Single-photon double ionization of ozone: experiment and theory

Abstract The triatomic molecule ozone (O3) is of outmost physical and chemical importance in the atmospheres of our Earth and other planets. Beyond its environmental significance, a detailed understanding of the electronic structure and ionization dynamics of ozone is essential f...

Effects of cephalexin treatment on DNA replication dynamics in Escherichia coli

Abstract Background In bacteria, DNA replication and chromosome segregation are tightly coordinated with cell division. The replication run-out method, which combines inhibition of transcription initiation by rifampicin with inhibition of cell division by cephalexin, is widely us...

Inclusive designs that allow the inclusion of a broader population in randomized controlled trials: An evaluation of randomization ratio and analysis strategy

In most multi-arm randomized controlled trials, all participants need to be eligible to be randomized to all the arms. This means some participants are excluded from participating in multi-arm studies. We propose to relax this by considering a 'differential randomization' approac...

To stall-cell or not to stall-cell: Variational data assimilation of 3D mean flow past a stalled airfoil

The full-field reconstruction of three-dimensional (3D) turbulent flows from sparse experimental measurements remains a significant challenge, particularly for flows exhibiting complex 3D flow separation. In this work, we address this challenge for the case of stall cells - spanw...

Advances in small area population estimation in the absence of national census data

Population data at small area scales are essential for effective decision-making, influencing public health, disaster response, and resource allocation, among others. While national censuses remain the cornerstone of population data, they are often constrained by high costs, infr...

Factors for Success and Failure of Allergen Immunotherapy ( AIT ) Trial Design in the Light of Evidence‐Based Medicine: Current Aspects 2026

Allergen immunotherapy (AIT) has been acknowledged as the only disease-modifying treatment for respiratory diseases since its introduction in 1911. Although the efficacy and safety have convincingly been established in numerous randomized clinical trials (RCTs), the AIT study res...

Compositional Neural-Cyber-Physical System Verification in the Interactive Theorem Prover of Your Choice

Formal verification of neuro-symbolic cyber-physical systems, such as drones, medical devices and robots, is complicated. Neural components must be trained to be optimal with respect to the available data as well as the safety specifications, and then verified using specialised s...

Exhumation of Grand Canyon’s basement along the Great Escarpment of Laurentia

The Grand Canyon encompasses two billion years of Earth history, but more than half this record is absent across a regionally extensive erosional surface known as the Great Unconformity. This enigmatic surface has been linked to multi-phase regional tectonics accompanying superco...

Evaluating Power-LawScaling Factors for HarmonicVibrational Frequencies across Model Chemistries

Abstract Scaling factors are derived for fundamental harmonic vibrational frequencies and molecular thermodynamic corrections using the recently developed wavenumber power scaling (WPS) method [Spectrochim. Acta, Part A2026, 359, 127967.]. WPS enables a simple two-parameter scali...

Seasonal biogeochemical cycling of permeable sediments in a temperate shelf sea environment

Abstract In highly productive shelf-seas, permeable sediments cover the majority of the benthic environment. However, most research has focussed on shallow environments where currents, tidal flows, terrestrial inputs and benthic productivity have a greater influence than in sedim...

Cognitively-Inspired Two-Stage Diffusion Policy for Adaptive Resource Scheduling in Sustainable UAV-Assisted Mobile Edge Computing Systems

In Unmanned Aerial Vehicle-assisted Mobile Edge Computing (UAV-MEC), dynamic workloads and limited onboard energy pose significant challenges for efficient task scheduling and long-term mission sustainability. Cognitively-inspired computing paradigms provide an intelligent soluti...

A quantitative and visual detection probe based on isothermal nucleic acid amplification coupled with CRISPR/Cas12a system (INACS) for miR155 detection

MicroRNAs (miRNAs) have emerged as ideal biomarkers for early clinical diagnosis. Achieving the accurate detection of miRNAs plays a critical role for assuring its implementation in their clinical applications. In this study, we developed a dual-signal amplified ultrasensitive fl...

Scaffolding strategic transition

Abstract This study investigates the cognitive mechanisms and pedagogical interventions involved in transitioning from rote memorisation to deep-processing strategies among Chinese postgraduate students entering a study-abroad context. While the superiority of deep processing is...

Catalogue of strong nonlinear surprises in ocean, sea-ice, and atmospheric variables in CMIP6

Abstract. The Coupled Model Intercomparison Project Phase 6 (CMIP6) archive was analysed for the occurrence of Strong Nonlinear Surprises (SNS) in future climate-change projections. To this end, we built an automated detection algorithm to identify SNS in a reproducible manner. T...

Extending eFall risk prediction to working-age adults within mental health and learning disability services: a clinical validation study

Abstract Most fall risk tools are developed for older adults; evidence in working-age populations receiving mental health services is limited. To externally validate the existing eFalls prediction model in working-age adults (18–65 years) within a UK integrated teaching National...

Remission of long-term conditions among adults with multiple long-term conditions in England primary care: A retrospective cohort study of 4.7 million people

Abstract Background Multiple long-term conditions (MLTC) are increasingly prevalent among UK adults, yet the extent to which remission of long-term conditions is recorded in routine primary care remains poorly understood. Accurate documentation of remission has implications for c...

Vulnerable groups’ engagement with interventions to mitigate the health impacts of exposure to extreme temperature events: a qualitative systematic review

Abstract Extreme temperature events are becoming more frequent. Such events are defined as unusually hot weather persisting for at least two consecutive days (heatwave) or unusually cold weather persisting for at least two consecutive days (cold wave) within the context of geogra...