University of Sheffield

Western amazon 2020 extreme heatwave

Abstract Between September and November 2020, an extreme climate event characterized by the co-occurrence of severe drought, extreme heat stress, widespread burning, and respiratory health impacts affected southwestern Amazonia. This study investigated the event using an integrat...

Supporting adults with intellectual disabilities to be more involved in decisions about their mental health medications: A co-produced mixed methods study

BACKGROUND: People with intellectual disabilities are more likely to take mental health (psychotropic) medications than other people. Despite long-standing concern about this, there has been little focus on how people with intellectual disabilities can be supported to be more inv...

Quantum Networking and Uplink Quantum Communications (v1.1.0)

Quantum Networking and Uplink Quantum Communications This snapshot repository contains the software codebase (v1.1.0) and supporting numerical data for the project. Note: This archive only contains the computational code, optimisation routines, and dataset files used to produce t...

Adenosine Deaminase-Mediated Purine Dysfunction Leads to DNA Repair Inhibition and Senescence in Sporadic Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by the death of motor neurons leading to paralysis and death generally 3–5 years post-symptom onset. ALS is a cell- and non-cell-autonomous disease, with glia such as astrocytes influencing disease p...

Applicants as reviewers: a mixed methods evaluation of the risks, benefits, and potential of distributed peer review for grant funding allocations

Abstract Background Peer review-based funding evaluation systems are under increasing pressure. To help alleviate this, innovative approaches like Distributed Peer Review (DPR) – where applicants review proposals for the same funding call – are being explored. The Volkswagen Foun...

Can silver diamine fluoride reduce negative impacts for young children with dental caries awaiting treatment under general anaesthesia? Protocol for a feasibility study

Abstract Background Many children require dental extractions under general anaesthesia (DGA) due to their young age, the number of carious primary teeth and their inability to cope with treatment under local anaesthetic. Children in England are waiting up to 80 weeks for a DGA. W...

Diblock Copolymer Nanoparticles Act as Nanoreactors for the Synthesis of Sterically‐Stabilized Inorganic Oxide Particles in Non‐polar Media

ABSTRACT Well‐defined diblock copolymer nanoparticles are prepared via reversible addition‐fragmentation chain transfer (RAFT) dispersion polymerization of 2‐hydroxyethyl methacrylate (HEMA) in a poly(α‐olefin) oil at 90°C using a poly(lauryl methacrylate) (PLMA) precursor. The P...

cIGW-SC: an intelligent chaotic hybrid grey wolf and sine cosine optimizer for complex engineering design problems

For intelligent systems designed to solve complex engineering design problems, premature convergence and the imbalance between exploration and exploitation remain key challenges for high-dimensional, multimodal, and composite problems. Existing approaches, including the Grey Wolf...

From Research Models to Journalist's Browser: An RSE Story from a 140,000-user Verification Tool

Disinformation and false content produced by generative AI often moves faster than journalists, fact-checkers and human rights defenders can verify. Across a decade of EU-funded projects - InVID (2016–2018), WeVerify (2018–2021), and vera.ai (2022–2025) - research groups have pro...

α-Latrotoxin and Pain: A Nociceptor Perspective on Latrodectism

Alpha-latrotoxin (α-LTX) is the principal vertebrate-specific neurotoxin in widow spider (Latrodectus) venom and a powerful presynaptic secretagogue. Although its receptors, pore-forming activity and stimulation of neurotransmitter release have been studied extensively in central...

Thalamic neuronal and bioenergetic function in painful diabetic peripheral neuropathy: a dual magnetic resonance spectroscopy study

Abstract Aims/hypothesis The aim of this cross-sectional study was to investigate three imaging parameters in people with type 2 diabetes to examine the volume, neuronal function and bioenergetic status of the thalamus in painful diabetic peripheral neuropathy (DPN) compared with...

The Implementation of Current UK Guidance for the Treatment of Co-Occurring Mental Health and Substance Use Conditions: A Mixed Methods Systematic Review and Thematic Synthesis

This review identified an implementation gap between best practice guidance and the provision of care for co-occurring conditions in the UK setting, which needs to be explored across a global context. There were positive examples of strategies to implement the guidance, particula...

Supraphysiological Testosterone Differentially Regulates Aortic Atheroma and Cardiac Remodelling in the Testicular Feminised Mouse

The cardiovascular actions of testosterone remain controversial, particularly regarding the safety of testosterone replacement therapy (TTh) in hypogonadal men. We investigated the effects of sustained supraphysiological testosterone exposure on aortic atherogenesis and cardiac r...

A qualitative examination of the content validity and acceptability of the EQ-5D-Y-3L and EQ-5D-Y-5L in adolescents with type 1 diabetes mellitus in Ethiopia

Abstract Background The EQ-5D-Y-3L and EQ-5D-Y-5L are widely used generic measures of health-related quality of life (HRQoL), including among children and adolescents with Type 1 Diabetes Mellitus (T1DM). However, evidence on the measures’ content validity and acceptability in lo...

Understanding variation between kidney centres in implementation of tolvaptan in the management of autosomal dominant polycystic kidney disease: a multiple case study

Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) affects an estimated 12.5 million people worldwide and 70,000 in the United Kingdom (UK). Tolvaptan is the only disease-modifying therapy available. Despite national guidelines, prescribing varies across UK...

Pain alleviation in diabetic neuropathy using hybrid closed loop insulin pumps (PAINLESS) – A randomised crossover trial protocol

Introduction Painful diabetic neuropathy (PDN) is a common complication of diabetes that leads to significant co-morbidity. Emerging evidence suggests glycaemic variability may be linked to fluctuations in pain intensity. Hybrid closed loop (HCL) systems reduce glycaemic variabil...

European Association of Palliative Care White Paper on research priorities for family caregiving in palliative care: A systematic review of reviews

BACKGROUND: Family carers are central to providing high quality palliative care. However, gaps remain in our understanding of how best to support carers. In 2010, the European Association for Palliative Care published a White Paper on 'Improving Support for Family Caregivers'. Th...

Diode area melting of Ti6Al4V: effects of multi-laser processing on microstructure and residual stress

Abstract Laser Powder Bed Fusion (LPBF) is a widely adopted additive manufacturing technique for producing geometrically complex metallic components. While this process yields fine microstructures that are beneficial for strength, the associated rapid thermal cycles generate stee...

Blood flow coordinates collective endothelial cell migration during vascular plexus formation and promotes angiogenic sprout regression via vegfr3/flt4

Nascent vascular networks adapt to the increasing metabolic demands of growing tissues by expanding via angiogenesis. As vascular networks expand, blood vessels remodel, progressively refining vascular connectivity to generate a more haemodynamically efficient network. This is dr...

Time to Act? Evaluating the Adequacy of the Public Libraries and Museums Act (1964) Through Public and Stakeholder Perspectives

This paper evaluates the adequacy of the Public Libraries and Museums Act (1964) for contemporary public library services in England. Drawing on a multi-phase mixed methods study, it compares public (user and non-user) perspectives identified in a Q study in Southeast England wit...