University of Sheffield

Printing‐Assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling

ABSTRACT The limitations of electrical neuromodulation are driving the development of neuroprosthetic systems enhanced with complementary modalities. A key technological challenge however remains the integration of the necessary hardware components (optical, thermal, fluidic, ele...

The Gravitational-wave Optical Transient Observer (GOTO) Fast Analysis and Spectroscopy of Transients (FAST) Surveys

Abstract The study of young and fast astronomical transients is often limited by the difficulty of acquiring data, particularly spectra, within hours to days of explosion. Historically, follow-up programmes have rarely obtained spectra until many days after discovery; coupled wit...

ACTIVATE: A protocol for a randomised controlled evaluation of Thumos: A cognitive-behavioural intervention for medical students

Background Medical students experience high rates of burnout and mental health distress, with approximately half reporting burnout, one-third experiencing depression, and one-tenth having suicidal thoughts. These issues are exacerbated during clinical placements and contribute to...

Epidermal microstructure and tactile sensitivity in the glabrous skin of hands and feet

Glabrous skin on the human palms and soles is specialised for mechanical interaction and is characterised by papillary ridges, an absence of hair follicles, and a thick stratum corneum. While gross morphological differences, such as the increased thickness of the plantar stratum...

From critique to praxis: reflections on the role of the critical accounting research community within UK academia

Purpose The interdisciplinary and critical accounting research community remains positioned at the margins of traditional academic projects, despite its longstanding role in academia. In this context, academics face job redundancies, resistance within accounting education and lim...

An inertial‐based spiral device for separating rare tumor cells from liquid biopsies

Abstract Early detection of primary tumors and metastatic processes increases the success of anti‐tumor therapies and favors good prognoses. Within the current range of methods available to detect the presence of tumors, liquid biopsy is receiving particular attention as it is a...

Principles and Practical Measurement and Control Strategies for Achieving Ultrahigh CO2 Capture Rates in Amine Post-Combustion Capture Plants

Abstract This study presents a practical feedback control strategy for conventional amine post-combustion capture (PCC) plants that is capable of achieving up to around 100% added CO2 capture (i.e., the exit CO2 is equivalent to the CO2 in the combustion air) with moderate energy...

Disentangling local adaptation and phenotypic plasticity in traits associated with altitude and temperature in widespread tropical butterflies

Climatic stratifications, in particular differences in temperature, occur along altitudinal clines. Understanding divergence across these regions can give insight into speciation and diversification, as well as how species may respond to climate change scenarios. Most past resear...

Creativity in the Improvised Drum Solo: South African Drummers’ Experiences through an Interpretative Phenomenological Lens

This article explores how expert South African drummers understand and experience creativity in improvised drum solos. While drumming is often examined in ensemble contexts, this study focuses specifically on unaccompanied solo improvisation—a setting in which the drummer must ne...

Is it possible to implement the DIALOG+ routine outcome monitoring system in a psychiatric rehabilitation inpatient setting? A mixed methods feasibility trial in the UK National Health Service

Abstract Background This study aimed to evaluate the feasibility and acceptability of implementing a routine outcome monitoring tool, DIALOG, and an associated intervention, DIALOG+, in psychiatric rehabilitation inpatient care wards in England. Methods This was a mixed-methods f...

From Prediction to Decision Making: PBPK and QSP as Regulatory‐Grade NAMs

New approach methodologies (NAMs) encompass a diverse and rapidly evolving set of experimental and computational tools designed to generate human‐relevant mechanistic data for use in drug development and regulatory decision making. Experimental NAMs provide insights into drug dis...

‘I can’t see what that path looks like’: making sense of help-seeking among women with breast cancer in rural and urban Scotland – an Interpretative Phenomenological Analysis

Scottish women living with breast cancer may face geographical and structural inequalities in accessing care and support, yet little is known about how differences in geography shape help-seeking. The aim of the present study was to explore these experiences among women living wi...

Beyond individual risk: social structure and the production of youth health risk behaviour in Indonesia

Background Adolescence and early adulthood are critical periods for the development of health behaviours, yet longitudinal evidence on how these behaviours are socially patterned in Indonesia remains limited. Drawing on life-course theory and the social determinants of health fra...

Quality of life and mental health in adolescents with idiopathic scoliosis undergoing brace treatment: a systematic review and pooled analysis of quantitative studies

Abstract Introduction Adolescent idiopathic scoliosis (AIS) is the most common paediatric spinal deformity. While bracing limits curve progression, its psychological and social effects remain unclear. This review and pooled analysis evaluate bracing’s impact on quality of life (Q...

Association between Glycemic Control and Survival in Patients with Type 2 Diabetes on Peritoneal Dialysis

Background: Diabetes is the leading cause of kidney failure globally affecting 40% of people receiving peritoneal dialysis (PD). High quality data on the potential impact of improving glycemic control is needed to inform the current recommendations to individualise HbA 1C targets...

Can Large Language Models Evaluate Grant Proposal Quality? Revisiting the Wennerås and Wold Peer Review Data

Abstract Purpose Despite the importance of peer review for grant funding decisions, academics are often reluctant to conduct it. This can lead to long delays between submission and the final decision as well as the risk of substandard reviews from busy or non-specialist scholars....

Children as Experts in Research and Assessment Design: A Participatory Approach to Evaluating Children and Young People’s Legal Capability

This paper reports on a co-design process adopted with children and young people when developing a situational judgement test (SJT) for use in a project that aimed to develop children’s legal capability via game-based learning. This paper details how children and young people’s e...

Accelerated mass loss of glaciers across Alaska since the Little Ice Age

Abstract Alaskan glaciers presently dominate contributions to global glacier mass loss and are projected to do so throughout the 21 st Century. Here we assess centennial-scale evolution and mass loss of 5289 Little Ice Age (LIA) glaciers by mapping geomorphological evidence of gl...

MiR-662 impairs C/D box snoRNA expression and rRNA 2′-O-ribose methylation marks

MiR-662 overexpression has been reported to promote breast cancer metastatic progression and to impair the expression of genes encoding for proteins involved in translation, ribosome biogenesis and ribosome processing (Puppo et al., 2023); however, the relationship between miR-66...

European ash pangenome reveals widespread structural variation and genetic basis of low ash dieback susceptibility

Abstract European Ash ( Fraxinus excelsior ) is a keystone tree species, whose populations are being decimated by ash dieback disease (ADB) – better characterisation of genetic variants associated with low susceptibility to the disease is needed. Here, we develop a F. excelsior p...