University of Science and Technology of China

Preprocedural estimated glomerular filtration rate and all-cause mortality after TIPS in cirrhosis: a single-center retrospective cohort study

Abstract Background : Renal dysfunction is increasingly recognized as an important determinant of prognosis in patients with cirrhosis undergoing transjugular intrahepatic portosystemic shunt (TIPS). However, the prognostic value of preprocedural estimated glomerular filtration r...

Reprogramming Sphingolipid Metabolic and Redox Homeostasis with an Injectable Botanicals/Nanozymes Hydrogel for Inhibiting Postoperative Recurrence and Metastasis in Breast Cancer

ABSTRACT Postoperative recurrence and metastasis in breast cancer remain major clinical challenges, primarily driven by persistent inflammation responses and secondary infections at surgical sites. These pathological processes trigger sphingolipid dysregulation and generate the r...

Prediction of early radiological response in esophageal cancer using CT radiomics and clinical factors: a single-center proof-of-concept study in an elderly cohort

Abstract Background To develop, as a proof-of-concept analysis, a machine learning model predicting early radiological treatment response in an elderly, single-center esophageal cancer (EC) cohort, and to test whether adding clinical factors to CT radiomics improves prediction. M...

Flame spread over flowing fuel under ignition delay: Spread and merging of flame front and fuel flow front

This paper investigates the flame spread over flowing liquid fuel under different ignition delays ( x ig ), substrate slopes ( θ ) and fuel discharge flow rates ( Q ). Focusing on flame front and fuel flow front, their spread and merging behavior, are concerned herein. Results sh...

Seismo-ripples

Earthquake prediction has long been considered one of the greatest challenges in the global scientific community due to the complex and uncertain nature of seismogenic processes, along with the prevailing consensus that earthquakes are inherently unpredictable. Here, we present a...

An Atomic-Scale Chemical Switch for Oxide Ferroelectricity

Abstract Interfacial chemistry offers new opportunities for designing ferroelectric materials, yet their coupling with intrinsic polarization remains largely unexplored. Here, we synthesize ferroelectric BiFeO3 nanoparticles with {100} facets covered by a Bi2FeO6-x Aurivillius-li...

Epitope and immunological basis for superior immunogenicity of henipavirus glycoprotein HeV.G over NiV.G in mRNA vaccines

Nipah (NiV) and Hendra (HeV) viruses are highly lethal zoonotic Henipaviruses with pandemic potential, for which no licensed vaccines exist. The surface glycoprotein (G) is the primary target of neutralizing antibodies, yet a systematic comparison of the immunogenicity of NiV.G a...

Aberrant lipid metabolic reprogramming accelerates gastric cancer malignancy through diminished ceramide-driven ALPP inhibition

Metabolic reprogramming is a canonical hallmark of cancer that reflects the biological properties of tumors. Deciphering the metabolic profiles and key metabolites involved in tumor progression is pivotal for advancing metabolism-centric precision oncology against gastric cancer...

Structural Softness–Rigidity Mediation Enables Multicolor Emission and Long‐Lived Phosphorescence in Hf/Zr Halides

ABSTRACT Multicolor fluorescence, typically favored by soft environments, and phosphorescence, which relies on rigid lattices to stabilize triplet excitons, are fundamentally incompatible and hard to coexist within a single material. Here, we report a crown–ether–directed lattice...

Assessing Meteorological, Local, and Upwind Information for Surface Ozone Through Machine Learning: Implications for Sustainable Urban Air Quality in Hefei, China

Ozone (O3) pollution remains a significant air quality issue in Chinese cities. Identifying which monitoring and modelling information provides reliable incremental value is important for efficient and sustainable urban O3 assessment. This study explored the incremental informati...

Structural Softness–Rigidity Mediation Enables Multicolor Emission and Long‐Lived Phosphorescence in Hf/Zr Halides

ABSTRACT Multicolor fluorescence, typically favored by soft environments, and phosphorescence, which relies on rigid lattices to stabilize triplet excitons, are fundamentally incompatible and hard to coexist within a single material. Here, we report a crown–ether–directed lattice...

Proteoform-Resolved Interaction Mapping of Target Protein Complexes in Living Cells via Tracelessly Releasable Cross-Linking

Abstract Proteoform-resolved interaction analysis is critical for understanding the functional diversity of multiple proteoforms from the same gene and their complexes. However, current technologies are still limited in resolving in vivo interactions at the proteoform level. In v...

Birch-Type-Reduced Carbazole Anions Enable Redox-Adaptive Super-Reducing Photocatalysis

Abstract Photocatalytic activation of inert chemical bonds is constrained by the redox potential of the catalyst. Here, we report a redox-adaptive photocatalytic strategy in which an electron-rich carbazole photocatalyst, CBZ6, functions as a molecular redox transformer through t...

High temperature oxidation and hot corrosion behavior of laser additive manufactured TiAl4822/TC25G graded materials at 750 °C

Laser additive manufacturing of titanium-based graded materials offers a promising route to enhance the performance of aero-engine compressors. However, the high temperature corrosion behavior of these materials remains difficult to predict due to compositional variations across...

Non-sewered sanitation systems reshape microplastics into chemically complex and reactive contaminants

Non-sewered sanitation systems (NSSSs) are gaining global attention as decentralized solutions, yet the transformation of microplastics (MPs) within these systems remains poorly understood. Here, we investigate MP characteristics in the influent and effluent of two NSSSs using la...

Correlative Soft X-ray Tomography and Transcriptomics Unveil How Calcium Alleviates Uranyl Cytotoxicity

Abstract Uranium contamination poses increasing environmental and health risks, yet the subcellular mechanisms underlying its toxicity and the protective effects of coexisting ions remain poorly understood. Here, by integrating cryo-SXT, transcriptomics, and physiological assays,...

Mapping the health management journey of patients with cardiac-involved Fabry disease

Fabry disease is a rare X-linked genetic disorder that frequently involves multiple organ systems, with cardiac complications being the leading cause of death. Although enzyme replacement therapy can slow disease progression, patients continue to face significant physical and emo...

Wetland restoration enhances ecological quality in urbanizing regions

Abstract Introduction Rapid urbanization and climate change drive widespread wetland degradation, yet it remains unclear whether wetland restoration improves ecological quality (EQ), a composite indicator reflecting vegetation, thermal, hydrological, environmental, and soil condi...

Physics-informed single-frame end-to-end learning for denoising and background removal in fluorescence imaging

Fluorescence microscopy is often limited by low signal-to-noise ratios arising from the finite number of detected photons and by an out-of-focus background that obscures structural details. Here, we introduce a physics-informed end-to-end learning framework that enables denoising...

Inverse Design of Multisource Thermal Metamaterials for Multifunctional Thermal Camouflage

ABSTRACT Controlling thermal transport in systems with multiple heat sources represents a fundamental and unresolved challenge in thermal science, where strong inter‐source coupling and complex source geometries readily destroy the spatial coherence required for reliable thermal...