University of Sassari

Oxidized-Lipid Signaling and Ferroptosis as Downstream Mechanisms of Titanium-Associated Peri-Implant Bone Loss

Titanium and its alloys remain the dominant materials in oral implantology, but degradation products released through corrosion, tribocorrosion, and wear are biologically active. This critical narrative review examines oxidized-lipid signaling and ferroptosis as candidate downstr...

The Characterization of a Compact CLLB:Ce Scintillation Detector for Mixed-Field Monitoring at a Muon Facility

Compact scintillation detectors with simultaneous gamma and neutron sensitivity are increasingly relevant for mixed-field monitoring and nuclear measurements under size and cost constraints. This work characterizes a compact Cs2LiLaBr6:Ce (CLLB:Ce) detector with integrated SiPM r...

Linking Rainfall Simulation and Single-Ring Measurements on a Swiss Alpine Hillslope: A Novel Framework for Surface Runoff Estimation

Surface runoff in alpine catchments is sensitive to rainfall intensity, resulting in substantial variations in runoff coefficients across rainfall scenarios. Although this dependency is well documented in the literature, it is often neglected in practical applications by assuming...

Breeding progress and climate adaptation in semi‑dwarf durum wheat: Genetic gains from long‑term multi‑environment trials under a Mediterranean environment

Durum wheat is a key cereal in Mediterranean agriculture, where productivity is challenged by climate change and yield stagnation. However, information on genetic gains after the introduction of Rht genes remains limited. This study quantified breeding progress and associated tra...

Molecular Pathogenesis, Global Epidemiological Trends, and Treatment Strategies for Pteropine Orthoreoviruses: A Narrative Review

Pteropine orthoreoviruses are emerging bat-borne zoonotic viruses of the genus Orthoreovirus (family Reoviridae), increasingly recognized as causes of acute respiratory disease in humans. Originally grouped with the largely non-pathogenic mammalian orthoreoviruses, they have chal...

Drought Variability and Cycles in Smallholder Farming Systems of the Sudano-Sahelian Region of Burkina Faso and Ghana

Rainfed smallholder farming systems in semi-arid tropical climates are highly vulnerable to drought, threatening food security and rural livelihoods. This study evaluates drought variability, severity, and temporal periodicity from 1981 to 2021 across representative Sudano-Saheli...

OurMED D3.4 Guidelines for Partners Capacity Development on Mediation Techniques. Version 1.2

This Deliverable (D3.4) stems from the OurMED Summer School on Participatory Processes and Environmental Conflict Mediation in Social-Ecological Systems, co-organised with the youth-led initiative NextGen4Med and held in Oristano (Sardinia, Italy) in September 2025. The guideline...

Predicting the risk of dehydration and readmission among rectal cancer patients with ileostomy: a multicenter observational study

Abstract Dehydration is a frequent complication among rectal cancer patients after ileostomy, often resulting in hospital readmission. The Dehydration Readmission after Ileostomy Prediction (DRIP) score was used to identify patients at risk of dehydration-related readmission. The...

Combined Botulinum Toxin Type A and Hyaluronic Acid Versus Exclusive Hyaluronic Acid Injections: A Potential Nonsurgical Alternative for Chin Augmentation

Nonsurgical chin augmentation with hyaluronic acid (HA) fillers is a widely used technique in aesthetic medicine. However, outcomes may be influenced by hyperactivity of the mentalis muscle, which may lead to reduced longevity. Botulinum toxin type A (BoNT-A) may improve filler i...

Integrating Hydro-Geomorphological Analysis into Regional Sediment Management: Insights from the Rio Geremeas Basin (Sardinia, Italy)

Mitigating flood risk and planning river corridors in Torrent-type Basins (TBs) requires integrated frameworks that link hydro-geomorphological processes with ecological quality, a combination currently lacking in regional planning. This study presents an integrated hydro-geomorp...

GIS-Based Assessment of Grassland Dynamics and Sustainable Pasture Planning in South and Nabatieh Governorates, Lebanon (2000–2024)

Sustainable pasture management is essential for preserving ecosystem services and supporting livestock production in Mediterranean environments experiencing increasing land-use pressure and climate variability. This study evaluates grassland dynamics in South Lebanon between 2000...

Robust inference and correlates from genetic associations with personality

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustne...

Beyond the Operating Room? Cytology-Based Yield and Resource Utilization of Outpatient Versus Operating Room EBUS-TBNA Pathways

Background/Objectives: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) can be performed via pathways that differ in anesthesia, setting, airway management, monitoring, recovery, and hospitalization. We compared an outpatient endoscopy suite pathway wi...

Discrepancies in the Molecular Epidemiology of Druggable Genetic Alterations in Non-Small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) represents most lung cancer diagnoses worldwide and remains a leading cause of cancer-related mortality. The advent of precision oncology has transformed the therapeutic landscape of NSCLC through the identification of druggable genetic alterati...

Neural encoding of symbolic, non-symbolic, and embodied non-symbolic numerical information in young and older adults

Numeracy has important implications across the lifespan, and age-related decline in this ability represents a vulnerability factor for older adults in managing everyday tasks, yet its mechanisms remain poorly understood. This study employed a parity judgment task to examine age-r...

Localized brain delivery of drugs via focused ultrasound-responsive bi-layer nanobubbles

Focused ultrasound (FUS) in combination with micro- or nanobubbles is a promising strategy for transiently and non-invasively opening the blood-brain barrier (BBB) to enable targeted drug delivery to the brain. Here, we report a FUS-responsive delivery system using bi-layer nanob...

Real‐world outcomes of venetoclax plus hypomethylating agents in unfit acute myeloid leukaemia: Results of the GIMEMA AML2320 trial

Summary Venetoclax (VEN) plus hypomethylating agents (HMAs) represents the standard of care for newly diagnosed acute myeloid leukaemia (AML) patients unfit for intensive chemotherapy, but prospective real‐world observational data outside randomized clinical trials remain limited...

Mycobacterium chelonae as an Underrecognized Cause of Granulomatous Disease in Fish and Humans: A Molecular One Health Study

Non-tuberculous mycobacteria are recognized as pathogens affecting aquatic animals and humans. Although Mycobacterium marinum is traditionally considered the principal etiological agent of fish mycobacteriosis and fish-tank granuloma in humans, the contribution of Mycobacterium c...

Real-World Antibiotic Strategies for Multidrug-Resistant Pseudomonas aeruginosa: Evidence from the Italian SUSANA Multicentre Study

Background/Objectives: Multidrug-resistant (MDR) Pseudomonas aeruginosa pneumonia and bloodstream infections (BSI) remain challenging because of their severity, limited therapeutic options, and high mortality, despite the availability of novel β-lactam-based agents. We aimed to d...

Speciation,Protein Binding, Biotransformation, andCytotoxicity of a VV–Lactate Complex

Abstract We studied the speciation, protein binding, biotransformation, and cytotoxicity of the dioxidovanadium(V) lactate complex Cs2[VV2O4(lact)2]·2H2O and compared the results with those obtained for the analogous malate compound. 51V NMR and ESI-MS results show that Cs2[VV2O4...