University of Sassari

Long-Term Survival of a Maxillary Subperiosteal Implant After Blast Injury: A 17-Year Follow-Up Case Report

Abstract Subperiosteal implants (SPIs) have re-emerged as a treatment option for the rehabilitation of patients with severe maxillary atrophy, although evidence on their long-term performance remains limited. We report the case of a 53-year-old female patient who underwent maxill...

Structural determinants of communicable disease risk in asylum reception centres

Introduction With over 120 million people forcibly displaced globally, asylum reception systems represent critical epidemiological interfaces. This synthesis is not confined to a single geographic region: evidence was drawn from reception systems across high-income host countries...

A Computational Workflow Integrating Explainable AI and Database Mining for the Prioritization of Antimicrobial Natural Products

The escalating threat of antimicrobial resistance demands the discovery of antibacterial agents with unprecedented chemical scaffolds. Natural products have historically been the most prolific source of antibiotics, yet the vast majority of catalogued natural products remain unte...

Surveillance, Detection and Therapeutic Innovation in Antimicrobial Resistance in the Age of Polycrisis: From Genomic and Digital Innovation to One Health Integration

Antimicrobial resistance (AMR) surveillance is increasingly strained by interconnected global crises, i.e., pandemics, climate change, armed conflicts, population mobility, and health inequalities, that disrupt healthcare delivery, diagnostic capacity, and laboratory infrastructu...

Lung disease in crisponi/cold-induced sweating syndrome type 1: expanding the clinical phenotype spectrum

Crisponi/Cold-Induced Sweating Syndrome Type 1 (CS/CISS1) is an ultra-rare genetic disorder caused by biallelic variants in the cytokine receptor-like factor-1 (CRLF1) gene and is associated with several comorbidities. Comprehensive data on the respiratory phenotype of this condi...

Trace Element Concentrations in Follicular Fluid and Serum and Their Association with Assisted Reproductive Technology Outcomes: Preliminary Evidence

The World Health Organization defines infertility as a disease of the male or female reproductive system characterized by failure to achieve pregnancy after 12 months of regular unprotected intercourse. Assisted reproductive technologies (ART) are widely used to address infertili...

Post-Marketing Reporting Patterns of Ceftazidime–Avibactam and Ceftolozane–Tazobactam: Analysis of Adverse Event Reports from EudraVigilance

Background/Objectives: Ceftazidime/avibactam (CA) and ceftolozane/tazobactam (CT) are WHO Reserve-group antibiotics increasingly used for multidrug-resistant Gram-negative infections. Comparative post-marketing pharmacovigilance data remain limited. Methods: A retrospective pharm...

Green-synthesized gold nanoparticles from Omani pomegranate peel: Phytochemical characterization and antileishmanial activity

Omani pomegranate peel is a rich source of phenolic compounds with antioxidant and antimicrobial properties, making it a promising source of antiparasitic bioactive compounds. This study compared air-dried (PPE1) and oven-dried (PPE2) Omani pomegranate peel extracts, chemically s...

Electrostatic Lens of a Charged Vortex

We study the local electrostatic response of a charged superfluid in the presence of a cylindrically symmetric vortex, allowing both the particle density and the thermodynamic compressibility to vary with the radial coordinate. Starting from the electrostatic charge response obta...

Persistent Post-Burn Pruritus Following Antihistamine Initiation: A Retrospective Longitudinal Study at a Single Italian Pediatric Burn Center

Background/Objectives: An operationally defined unchanged itch-score sequence may indicate persistent symptoms rather than symptom resolution. We described pruritus following antihistamine initiation in children with burns and examined how its apparent stabilization depended on t...

Migraine in Real-World Clinical Practice: Patient Burden, Healthcare Utilization and Unmet Needs—A Cross-Sectional Analysis of the I-GRAINE Study

What are the main findings?Migraine care in Italy is characterized by a mismatch between healthcare resource utilization and clinical needs, with limited primary-care involvement, repeated specialist consultations, and healthcare nomadism.Healthcare resource utilization is substa...

Deep Eutectic Solvents (DES) and Natural Deep Eutectic Solvents (NADES)-Mediated Extraction of Bioactives from Brewing By-Products: A Scoping Review for Functional Food and Sports Supplementation

The brewing industry generates substantial organic waste, prompting interest in sustainable valorization because these by-products retain significant residual nutritional and nutraceutical value. Based on these premises, this scoping review aims to evaluate whether DES- and NADES...

MRI Characteristics of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Importance Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a demyelinating disease distinct from multiple sclerosis (MS) and aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD). Magnetic resonance imaging (MRI) is central t...

Economic evaluation of standard versus integrated short peripheral catheters

BACKGROUND: Integrated short peripheral catheters (ISPCs) have been developed to reduce the risk of catheter failure compared with traditional short peripheral catheters (SPCs). Although clinical benefits have been demonstrated in randomized studies, economic evidence remains inc...

Polar and e-Radical Strain-Release Strategies for Accessing Functionalized 2-Oxabicyclo[2.1.1]hexan-3-ones from Bicyclo[1.1.0]butanes

Abstract 2-Oxabicyclo[2.1.1]hexanes (OBHs) have emerged as valuable saturated aromatic replacements, whereas their lactone analogues, 2-oxabicyclo[2.1.1]hexan-3-ones (OBHOs) remain underexplored, because of limited synthetic access. Herein, we report complementary polar and elect...

Digital responsibility, skills and environmental awareness for digital sustainability

This study investigates how digital competencies and environmental awareness interact to shape eco-friendly digital practices, contributing to the field of digital sustainability. Drawing on a representative sample of adult internet users in the United Arab Emirates (N = 1016), i...

The Marine Biomonitor Mytilus galloprovincialis: A Study on Microplastics as a Vector for Heavy Metals Pollution in Sardinia (Italy)

The main objective of the present study was to assess the contamination level and nature of microplastics and their role as vectors of trace elements in Mediterranean mussels (Mytilus galloprovincialis). A total of 39 samples were collected from four farming areas (1–4) located i...

Endogenous Bioelectrical Modulation of Redox, Vascular Support, and Extracellular Matrix-Related Markers in Human Fibroblasts Following the REAC CO-IBZ Protocol

Background: Fibroblasts are active regulators of tissue architecture, extracellular matrix organization, vascular support, oxidative balance, and stress-related cellular responses. The present study aimed to characterize the molecular response of human foreskin fibroblasts (HFF1)...

FOXC1 and its lncRNA FOXCUT link DNA methylation to a chondrocyte phenotype dysfunction

Abstract Objective With current osteoarthritis (OA) therapies limited to symptom management, understanding molecular drivers of disease progression is critical. As epigenetic mechanisms increasingly appear central to OA pathogenesis, this study aimed to identify epigenetically dy...

Online and in-person Dialectical Behavior Therapy skills training for university students: a non-randomized comparative trial of feasibility and outcomes

Introduction There is a growing need to implement cost-effective interventions for university students and Dialectical Behavior Therapy (DBT) - Skills Training (ST) has shown promising results as a stand-alone intervention in various settings.Aims This pre-post study aims to eval...