University of San Diego

Discovery of Sphaeriaurantinsas Rapid-Acting Antiplasmodialswith Dual Activity in Blood and Liver Stages

Abstract The rapid emergence of resistance in the malaria-causing protozoan Plasmodium falciparum has heightened the demand for treatments with novel modes of action. Having evolved to produce a myriad of structurally diverse natural products (NPs) as defenses against soil-dwelli...

Implementation of clinical grading committees in internal medicine sub-internships: implications for assessment accuracy and standardization

The Internal Medicine clerkship has faced challenges in ensuring fair and accurate grades, with past studies examining areas including unconscious bias, inter-rater reliability, and variability. To address these issues, the Alliance for Academic Internal Medicine recommends the u...

Demonstratingthe Chemoselective Lewis Acid Activityof Pyridine(Diimine) Bismuth Cations

Abstract Herein, we describe the preparation of a library of cationic bismuth(III) pyridine(diimine) compounds and the assessment of their Lewis acidity measured by their interaction with phosphine oxides, acid halides, and ketones. These bismuth compounds have acceptor number va...

A Melanoma Transplanted in Nude Mice Has Both Host‐ and Tumor‐Derived Blood Vessel‐ and Nerve‐Like Structures

Nestin-expressing stem cells located in the bulge area of the hair follicle can give rise to multiple cell types. In the present study, we subcutaneously transplanted red fluorescent protein (RFP)-labeled SK-MEL-5 human melanoma cells into nestin-driven green fluorescent protein...