University of Pecs

Diagnostic Accuracy of PID‐5‐BF for Screening Personality Disorders: A Cross‐Sectional Study in Clinical and Nonclinical Samples

ABSTRACT The DSM‐5 Alternative Model for Personality Disorders introduced a dimensional approach to personality pathology, with maladaptive traits assessed by the Personality Inventory for DSM‐5 Brief Form (PID‐5‐BF). Despite extensive validation, evidence on its diagnostic accur...

Agricultural Biotechnology 4

STRATEGIES TO PRODUCE TRANSGENIC INSECT-RESISTANT PLANTS, STRATEGIES FOR PRODUCING TRANSGENIC HERBICIDE-RESISTANT PLANTS

Sustainable iodine contrast media for a healthy future (SUSTAINED): a global survey of practice

Abstract Objectives To investigate healthcare professionals’ knowledge, attitudes, and practices (KAPs) of the environmental impact and sustainability of iodinated contrast media (ICM). Materials and methods A cross-sectional web-based survey was distributed to members of profess...

Management Strategies for Cutaneous Adverse Events Caused by Kinase Inhibitors in Oncology: A Systematic Review and Meta-Analysis

Background: The use of targeted therapies in oncology has increased significantly, but associated cutaneous adverse events often impair quality of life and adherence. Despite numerous available interventions, there is no unified protocol, and many patients discontinue therapy due...

SARS-CoV-2-Specific IgG Levels Are Inversely Associated with ACPA-Reactive Pathological and Natural Autoantibody Profiles in Residual Diagnostic Samples

Background/Objectives: SARS-CoV-2-specific antibody levels vary among patients with systemic autoimmune rheumatic diseases (SARDs). In rheumatoid arthritis (RA), the most prevalent SARD, this is further shaped by rheumatoid factors (RFs). Attenuated post-vaccination antibody leve...

Device-Measured Physical Activity, Sedentary Time, and Cardiometabolic Risk Markers in Youth

Importance The evidence for benefits of higher physical activity and lower sedentary time on the cardiometabolic risk profile in youth is based on cross-sectional and small prospective studies. Objective To determine the prospective associations between device-measured physical a...

MICROBIOLOGY LABORATORY INTRODUCTION

MICROBIOLOGY LABORATORY INTRODUCTION

Targeted market survey of undeclared sildenafil in high-risk sexual enhancement supplements marketed in Hungary

Abstract Undeclared phosphodiesterase type 5 (PDE5) inhibitors in dietary supplements marketed as natural sexual enhancers remain a consumer protection and food safety concern. This article investigates the occurrence of undeclared sildenafil in 12 high-risk sexual enhancement su...

Bacterial actin MreB as a new antibiotic target

Actin homolog MreB plays a crucial role in the synthesis of the bacterial cell wall. Disruption of the MreB filament network results in the disruption of the cell wall, which thus serves an unconventional antibacterial strategy. A22, a small inhibitor molecule, binds directly to...

Snakes are perceived as more threatening and disgusting in urban compared to natural environments

Abstract Wildlife in cities is often perceived as ‘out of place’ because urban environments are considered human territory. This can lead to stronger negative emotional responses than encounters in natural habitats. A representative sample of adults (n = 500) rated pictures of sn...

Special Issue “Molecular Links Between Sensory Nerves, Inflammation, and Pain 3.0”

Pain is a complex sensation that emerges from dynamic interactions of sensory neurons, immune and inflammatory mechanisms, membrane signaling processes, and central nervous system networks [...]

Antibody-drug conjugate engineering: from design to efficacy and safety

Antibody–drug conjugates (ADCs) represent a rapidly expanding class of targeted cancer therapeutics that combine the high selectivity of monoclonal antibodies with the potent cytotoxic activity of small-molecule drugs. Their clinical success relies on the simultaneous optimizatio...

New record and description of a male Murina kontumensis (Kon Tum Tube-nosed Bat) from Vietnam

Abstract The Kon Tum Tube-nosed Bat ( Murina kontumensis Son et al. 2015. A new species of the genus Murina (Chiroptera: Vespertilionidae) from the Central Highlands of Vietnam with a review of the subfamily Murininae in Vietnam. Acta Chiropterol. 17: 201–232) was described from...

Household socioeconomic variation, caregiver well-being, and selected early health-related indicators among families with children aged 0–3 years living in disadvantaged settlements in Hungary

Household socioeconomic conditions during early childhood may be associated with caregiver well-being, parental health behaviors, dietary/feeding-related conditions, and selected preventive healthcare utilization indicators. This study aimed to explore how household-level socioec...

Mapping the evidence on interventions to reduce potentially inappropriate prescriptions in older adults: a scoping overview of 127 systematic reviews

Potentially inappropriate prescriptions (PIPs) are highly prevalent among older adults and associated with adverse outcomes, including hospitalisations and mortality. Numerous interventions have been evaluated and synthesised in reviews, but the review-level evidence remains hete...

TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala

Abstract Background and purpose TRPM3 is best known for its role as a peripheral sensor of pain and heat. Recent studies reporting gain‐of‐function TRPM3 mutations in patients with neurodevelopmental and epilepsy‐associated disorders suggest a previously unrecognized role of this...

Resurrection from Dinosaur Footprints: Shifting from a Coal Mining Past to a ‘Geoheritage’ Future. The Successful Shift of Komló city (Mecsek Mountains, Hungary, Europe)

Abstract A new exhibition centred around the 3D, 1:1 scale artistic reconstruction of the hypothetical Jurassic dinosaurs that left Komlosaurus carbonis isp. footprints and track sites (Hettangian, Early Jurassic) in the deltaic facies of the Mecsek Mountains (South Hungary, Cent...

Concentration-to-Dose Ratio Differences Between Once-Daily Tacrolimus Formulations: A Five-Year Real-World Pharmacokinetic Study in Kidney Transplantation

Tacrolimus is a cornerstone of immunosuppression after kidney transplantation; however, its narrow therapeutic window and substantial inter- and intra-individual pharmacokinetic variability complicate dose optimization. Extended-release tacrolimus (ER-Tac) and MeltDose ® prolonge...

The relationship between inflammation and multiple myeloma: insights into alterations and prognostic value

Abstract Multiple myeloma (MM) is an inflammation-driven plasma cell malignancy influenced by the bone marrow microenvironment. Dysregulated cytokine networks and neuroimmune factors may contribute to disease progression and extramedullary disease (EMD), a high-risk variant with...

Optimizing genotype and nitrogen management for improved yield and agronomic efficiency in dry direct seeded rice under temperate ecology

Rice production through conventional transplanting is becoming increasingly difficult because of limited water resources and labor shortages. Dry direct-seeded rice (DSR) offers a practical alternative with lower water and labor requirements. However, the success of DSR depends o...