University of Pecs

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

P1.017. Innovative Applications of the Internal Mammary Artery in Supercharged Colon Replacement

Abstract Topic Benign Disease: Esophageal Surgery Background Esophageal reconstruction poses significant challenges, particularly when traditional methods are not viable. This study explores innovative applications of the internal mammary artery (IMA) in supercharged colon replac...

From general-purpose models to purpose-built artificial intelligence Systems for Health economic Modeling

INTRODUCTION: Health economic models (HEMs) provide a solid foundation for reimbursement policy decisions that shape patient access to new treatments and the allocation of scarce healthcare resources. Model development is labor-intensive and time-consuming, often requiring months...

Acute adaptations in dynamic torque and torque control to practicing with known and unknown sequences of concentric and eccentric muscle contractions in healthy young adults

Abstract Background During human movement, the neuromuscular system continuously adapts to varying and differently predictable demands. Practicing with sequences of known and unknown types of muscle contractions could train force control of muscle. We compared the acute effects o...

Availability and representativeness of freshwater macroinvertebrate data to enable Europe-wide assessment of biodiversity trends

Freshwater ecosystems, though covering less than 1% of Earth's surface, harbor around 10% of all species. Pressures like pollution, water extraction, and habitat loss can exhibit complex interactions in their effects on freshwater biodiversity. Understanding the effects of these...

Concurrent validity of wearable inertial sensors for postural sway assessment during quiet standing compared with force plates: a systematic review and meta-analysis

Abstract Wearable inertial sensors are increasingly used for postural sway assessment, but their concurrent validity with force plates during quiet standing has not been quantitatively synthesized. This systematic review and meta-analysis (PROSPERO: CRD42024596870) pooled concurr...

Technology-enhanced learning in nursing education: a systematic review

Abstract Background Technology-enhanced learning (TEL), including artificial intelligence (AI), virtual reality (VR), high-fidelity simulation (HFS), and gamification, is increasingly used in nursing education to address limitations in clinical training and support the developmen...

Robust LigandDocking into Challenging Hydrated BindingPockets

Abstract Correctly positioning water molecules at the drug-target interface is a major challenge in structure-based drug design. Predicting how water structure reorganizes during drug docking into the target pocket is particularly difficult. Previously, a molecular dynamics-based...

Combined Marbofloxacin-Geraniol-Tris-EDTA Exposure Delays Marbofloxacin Resistance Escalation in Pseudomonas aeruginosa While Early Genomic Changes Remain Limited

Background: Pseudomonas aeruginosa combines intrinsic resistance, adaptive plasticity, and biofilm formation, making treatment failure common in veterinary and human medicine. We examined whether geraniol and Tris-ethylenediaminetetraacetic acid (Tris-EDTA) modulate marbofloxacin...

Characteristic central nervous system fingerprints and related molecular signatures in difficult-to-treat rheumatoid arthritis

Abstract Background Despite guideline-recommended treatment, approximately 30% of rheumatoid arthritis (RA) patients remain symptomatic and are classified as difficult-to-treat (D2T), representing an unmet clinical need. D2T RA is a heterogeneous state potentially involving diffe...

Temperature-Defined Heat-Alert-Threshold Days and Acute Myocardial Infarction Admissions and Mortality: A Nationwide Hungarian Registry-Based Cohort Study

Background: Although extreme heat is associated with adverse cardiovascular outcomes, the relationship between heat-alert-threshold days, acute myocardial infarction (AMI) admissions, and post-AMI mortality remains uncertain. We aimed to evaluate the association between temperatu...

When Appearances Deceive: Rape Myth Schemas Influence Attractiveness Effects Across Cultures

ABSTRACT Research on sexual assault judgements has shown that extra‐evidentiary cues influence perceptions of victims' credibility and responsibility. This study examined how physical attractiveness, rape myth acceptance (RMA), participant sex and cultural context shape victim bl...