University of Opole

Choosing Between Anti-TROP2 ADCs in Advanced Breast Cancer Without Head-to-Head Evidence: A Practical Evidence-Informed Decision Framework Endorsed by the Polish Society of Clinical Oncology

Background/Objectives: Antibody–drug conjugates (ADCs) targeting trophoblast cell-surface antigen 2 (TROP2), including sacituzumab govitecan (SG) and datopotamab deruxtecan (Dato-DXd), have expanded treatment options for patients with advanced breast cancer. Although both agents...

Limitations of Fried frailty criteria in kidney transplant recipients with arteriovenous fistulas

Background: Kidney transplant recipients (KTRs) are prone to development of muscle dysfunction and frailty. This study aimed to assess muscle strength and body composition alterations in KTRs, and whether an arteriovenous fistula (AVF) can influence handgrip strength (HGS) result...

Thrombosis of a femoropopliteal vein graft as a complication of COVID-19 vaccination, with subsequent recanalization of the graft following gene therapy

Chronic limb-threatening ischemia (CLTI), formerly referred to as critical limb ischemia (CLI), is characterized by ischemic rest pain and tissue loss (ulceration or necrosis) in the presence of objectively documented arterial insufficiency, and is associated with a high risk of...

Fate of post-blast residue in soils from an armed conflict zone determined by magnetic, microbiological, and ecotoxicological assessments

Weapon detonations generate substantial quantities of post-blast residue (PBR), which contributes iron-rich particles to soils. After deposition, these residues undergo redox transformations that produce bioavailable iron compounds, potentially increasing phytotoxic risks to agri...

The genus Trynocoris Herring, 1976 (Heteroptera: Miridae: Cylapinae) is no longer monotypic: T. costaricaensis sp. nov. from Guanacaste, north-western Costa Rica

This dataset contains the digitized treatments in Plazi based on the original journal article Gorczyca, Jacek, Taszakowski, Artur, Wolski, Andrzej, Chérot, Frédéric (2022): The genus Trynocoris Herring, 1976 (Heteroptera: Miridae: Cylapinae) is no longer monotypic: T. costaricaen...

Functionalized peptides incorporating non-canonical ɑ–amino acids: copper(II) coordination and cytotoxic activity

Unusual ɑ–amino acids, owing to their ability to accommodate diverse substituents while preserving a chiral center, constitute valuable building blocks in peptidomimetic design. Their incorporation enables fine-tuning of physicochemical and biological properties, while also provi...

Antibiotics and the Endocrine System: Mechanisms, Adverse Effects, and Clinical Implications

Background/Objectives: Antibiotics are widely used in clinical practice, yet their potential effects on endocrine homeostasis remain insufficiently recognized. This review summarizes endocrine adverse effects associated with selected antibacterial agents, their proposed mechanism...

Severity Benchmarks for the Pennsylvania Inventory of Scrupulosity: Brief Screening Measure for Pastoral Care and Counseling

The objective of the present study was to determine whether the Pennsylvania Inventory of Scrupulosity (PIOS) can effectively distinguish between individuals with clinically significant religious scrupulosity and those experiencing non-pathological religious concerns. To establis...

Role of Astrocytes in Central Respiratory Control

Astrocytes, once regarded primarily as structural and metabolic support cells, are now increasingly recognized as active participants in neural information processing. Within respiratory control networks, astrocytes are widely distributed throughout the brainstem and spinal cord,...

Life satisfaction of socially active older adults aged 60–89: the role of health status, individual, and environmental factors

The aging population presents significant challenges for public health and social policy, particularly in the context of maintaining life satisfaction in later life. This study aimed to assess life satisfaction among socially active older adults aged 60–89 in Poland, with particu...