University of New Mexico

End processing in NHEJ by Polymerase λ and PNKP is coordinated during short-range synapsis

Non-homologous end joining (NHEJ) is a major pathway of DNA double strand break (DSB) repair, capable of directly joining both damaged strands of DNA through the coordinated activities of repair factors that detect the termini, physically bridge them together, and perform the che...

SHAPRP: A SHAP-Guided Framework for Efficient RSS Estimation in 5G/B5G Networks

As bandwidth-intensive applications proliferate and the usage of wireless devices surges, fifth-generation (5G) and beyond (B5G) networks are challenged to enhance coverage, reduce latency, and improve efficiency. The application of machine learning (ML) models for received signa...

Photoactivated Cross-Linking Mass Spectrometry for Probing Multidomain Protein Dynamics in Inducible Nitric Oxide Synthase

Abstract Cross-linking mass spectrometry (XL-MS) with photoactivatable reagents has been increasingly applied to probe protein conformational dynamics; however, its sensitivity to shifts in conformational equilibrium involving transient, sparsely populated docked states within mu...

Molecular basis of nick ligation in the nucleosome by DNA Ligase IIIα

Eukaryotic genomic DNA is packaged into chromatin through a fundamental repeating unit known as the nucleosome core particle. Within this chromatin context, genomic DNA is constantly exposed to endogenous and exogenous stress that result in the formation of DNA damage, which must...

Adapting NDBIs for Autistic Children Who Use Echolalia: A Cascading Coaching Approach to Supporting Communication and Language Development

This pilot study examined a cascading coaching model to train graduate student clinicians and caregivers to use adapted Naturalistic Developmental Behavioral Intervention (NDBI) techniques with autistic preschoolers who use echolalia. Adaptations were designed to incorporate chil...

Do Not Play: Recognizing Spiritual Distress in Serious Illness

Spiritual distress is a significant yet frequently underrecognized component of serious illness and palliative care. Although spirituality is recognized as a core domain of quality palliative care, patients often express spiritual suffering through grief, mistrust, anger, identit...

Temporal Data Structure Is Not Causal Identification: A Practical Framework for Appraising Causal Claims in Prevention and Population Health Research

Abstract Temporal data structure is not an identification strategy. In manuscript review and reporting, cross-sectional and longitudinal labels are sometimes used as shorthand for judging whether causal claims are appropriate. Whether a causal claim is credible depends on the eff...

A data-driven single substitution to overcome bias from conventional single substitution for LOD missingness in covariates in least squares regression

The Limit of Detection (LOD) is the threshold below which a measurement is considered too low to be reliably quantified. Even though advanced statistical methods exist for dealing with the values below the LOD, simple approaches are still frequently used in real-world settings. C...

ReMeDy : A Flexible Statistical Framework for Region‐Based Detection of DNA Methylation Dysregulation

Region-based epigenome-wide association studies have demonstrated improved statistical power and biological interpretability compared with probe-wise analyses of DNA methylation data. However, most existing region-based methods characterize methylation dysregulation primarily thr...

An axon-intrinsic loop restricts nerve regeneration through axonal protein synthesis

ABSTRACT Injured axons synthesize the RNA Binding Protein KHSRP that promotes mRNA decay and slows nerve regeneration. Axotomy-induced increase in axoplasmic Ca 2+ activates axonal Khsrp translation, and while Ca 2+ returns to pre-injury levels within 16 hours post-axotomy, axona...

Cost of Article Processing Charges to Adhere to National Institutes of Health Public Access Policy

This economic evaluation estimates investigator payments of article processing charges to journal publishers to allow immediate public access to their published federally funded research.

History of divergence and gene flow shaping geographic variation in Andean warblers (Myioborus).

Studying how genetic variation is structured across space, and how it relates to divergence in phenotypic traits relevant to reproductive isolation, is important for our understanding of the speciation process. We used ddRAD-seq data to examine genetic variation across the distri...

Gemfibrozil promotes longevity and health by restricting amino acid uptake through the Dipeptide transporter, PEPT1

The FDA-approved fibrate, gemfibrozil, has been used clinically to treat hyperlipidaemia, showing efficacy both in lowering triglycerides and increasing high-density lipoproteins. However, in recent years, the drug has been increasingly investigated for potential clinical use in...

The Telephone AI Paradox: How Voice Agents Can Help Counter Unwanted Telemarketing Through Role-Based Automation, Transparency, and Governance

Unwanted telemarketing calls are a persistent source of consumer frustration and a legally regulated issue in Germany. At first glance, the idea of addressing this problem with AI-based voice technology appears contradictory: why should an automated caller help restore trust in a...

Polymer Quantum Mechanics on Compact Configuration Spaces

“Polymer quantum mechanics” is the name given to a quantization scheme inspired by loop quantum gravity in which the configuration space of the theory is chosen to have a discrete topology. Polymer quantization yields a representation of the canonical commutation relations that i...

Theta deep-brain stimulation improves cognitive performance in Parkinson’s patients with cognitive impairments

ABSTRACT Background Patients with Parkinson’s disease (PD) almost inevitably experience cognitive impairments. These deficits have been linked to low frequency “theta” cortical activity ∼4 Hz, previously associated with cognitive control. Objective Our study investigated effects...

Age and Race Differences in the Association Between Social Support and Leisure-Time Physical Activity Among Adults With Cognitive Difficulty: Evidence From the 2023 BRFSS

Purpose To examine the association between perceived social/emotional support (PSES) and leisure-time physical activity (LTPA) among U.S. adults with self-reported cognitive disabilities, and to explore moderation by age and race. Design Cross-sectional analysis of 2023 Behaviora...

Stereotactic Body Radiotherapy vs Moderately Hypofractionated IMRT for Localized Intermediate-Risk Prostate Cancer

Importance The treatment of prostate cancer with radiotherapy is evolving. How quickly radiotherapy can be delivered, and the relative risks and benefits of such a treatment, is of significant public interest. Objective To determine whether stereotactic body radiotherapy (SBRT) w...

Identification of vaccine candidates by immunization with a complex pool of recombinant VLPs

Identifying the regions of a protein that can be readily translated into an effective vaccine remains a major challenge in epitope-focused vaccine design, especially when a protein is poorly characterized. Here, we describe an immune-driven strategy for epitope identification whi...

Extreme vulnerability to intruder attacks destabilizes network dynamics

Abstract Consensus, synchronization, formation control, and power grid balance are examples of desirable dynamical states that arise in networks. Here we investigate how such states can be destabilized by an intruder agent within an otherwise functioning network. We see that a si...