University of Massachusetts Dartmouth

A compilation of global bio-optical in situ data for ocean-colour satellite applications – version four

Abstract. A global in situ dataset for validation of satellite products from the ESA Ocean Colour Climate Change Initiative (OC-CCI) is presented. This version of the compilation, with data starting in 1996, extends to 2025, which is important for the validation of recent algorit...

Host DNA repair factors empower a mechanism of antiviral nucleoside analog resistance

ABSTRACT How host functions affect resistance to antiviral drugs is poorly understood. Ganciclovir, a chain-terminating nucleoside analog, is a first-line therapy against human cytomegalovirus, a widespread herpesvirus that causes life-threatening disease in immunocompromised ind...

Genomic catalogue of giant viruses reveals expanded diversity and functional potential

Nucleocytoplasmic large DNA and Mirusviricota viruses exhibit taxonomic richness which continually expands due to metagenomic sequencing. Here we curate a database of giant virus metagenome-assembled genomes (GVMAGs V2), comprising 8,508 species-level representatives from 18,727...

A culture collection of bacterial isolates from Lake Erie and Lake Victoria

We present a culture collection of 44 aquatic bacterial cultures isolated from samples collected from Lake Erie's Sandusky and Maumee Bays and Lake Victoria's Winam Gulf. Here, we detail isolation, cryopreservation, and genomic DNA preparation methods and sequences of full-length...

Management of Pre-Existing Inflammatory Arthritis During Immune Checkpoint Inhibitor Therapy for Metastatic Renal Cell Cancer with a TNF Inhibitor for over 6 Years: A Case Report

Background The use of immune checkpoint inhibitors (ICIs) has transformed cancer care by using the body’s own immune system to target malignant cells. ICIs can cause unintended off-target effects, termed immune related adverse events (irAEs), which can be de novo or related to pr...