University of Massachusetts Boston

Artificial intelligence-enabled analysis of electron micrographs to assess mitochondrial morphology in triple-negative breast cancer

Advancements in transmission electron microscopy (TEM) have enabled in-depth studies of biological specimens, offering new avenues to large-scale imaging experiments with subcellular resolution. Mitochondrial morphology is of growing interest in cancer biology due to its crucial...

Economic (In)security and Living Arrangements in Later Life: Heterogeneity by Race-Ethnicity

Changes in economic security and living arrangements among the diverse, aging U.S. population are not experienced uniformly. Using Health and Retirement Study data linked to the Elder Index TM —an income measure of older adult needs—we estimated discrete-time competing risks mode...

Proteomic analysis of human chronic traumatic encephalopathy brain implicates proteasome and ribosome dysfunction in disease severity

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that occurs in individuals with repeated head impacts (RHI) exposure, including contact sport athletes, military personnel, and domestic abuse victims. Despite growing recognition of CTE, the molecular mechanis...

Room-temperature multiferroicity in all–van der Waals heterostructures

Multiferroics host simultaneous and coupled ferroic orders, allowing disparate external stimuli to induce abrupt transformations in their structures and properties. Creating multiferroicity in two-dimensional (2D) van der Waals (vdW) platforms would add the elements of strong qua...

Suffering, Trauma, and Relational Integration: Re-Envisioning Spiritual Care and Psychoanalysis in a Decolonial Age

Spiritual care is summoned by suffering—by ‘wounds’ that are psychological, relational, spiritual, embodied, and political at once. As disciplines continue to be entrenched and siloed amidst the growing sociopolitical tensions and global crises in a decolonial age, what is at sta...

Safety and Tolerability of Chronic Carvedilol in Pediatric Dilated Cardiomyopathy: A Report from the Pediatric Cardiomyopathy Registry

Long-term studies on safety of beta-blockers in pediatric heart failure (HF) are scant. We describe the safety profile, dose ranges, and tolerability of carvedilol in pediatric dilated cardiomyopathy (DCM). The Pediatric Cardiomyopathy Registry (PCMR) was used to identify patient...

Manipulation of biological systems by self-defecting and foreign agents

Biological systems maintain structure and function through hierarchical control, redundancy and surveillance across scales. These same features create leverage points for agents that establish a persistent presence in host systems, including foreign agents such as pathogens, para...