University of Leeds

Racially minoritised workers’ incivility experiences, and consequences within maternity settings: a multimethod longitudinal qualitative exploration

Abstract Background Workplace incivility is a global concern in healthcare, undermining staff wellbeing, organisational functioning and patient safety. In England, despite National Health Service (NHS) commitments to equality and inclusion, racially minoritised staff continue to...

TCOM-CFC11 and TCOM-CFC12: a gap-free, observationally constrained global dataset of stratospheric CFC-11 and CFC-12 profiles (v2.0)

Abstract. Understanding the long-term trends of ozone-depleting substances (ODSs), particularly CFC-11 (CFCl3) and CFC-12 (CF2Cl2), is essential for evaluating the effectiveness of the Montreal Protocol. However, reliably estimating these trends is complicated by the inherent spa...

Oral dysbiosis: methodological evolution, the mobile resistome and the future of machine learning in dentistry

The oral microbiome acts as a significant, yet often overlooked, reservoir for antimicrobial resistance genes (ARGs). This review examines the role of the human resistome in oral health, evaluating current knowledge on the composition, function and dissemination of ARGs within th...

Daratumumab, lenalidomide, and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: MAIA final survival analysis

Abstract In previous analyses of MAIA, daratumumab plus lenalidomide/dexamethasone (D-Rd) significantly improved progression-free survival and overall survival (OS) versus lenalidomide/dexamethasone (Rd) in transplant-ineligible newly diagnosed multiple myeloma (NDMM). We report...

Sonographer Clinical Skills Training: What Can We Learn From International Education and Clinical Training Models to Address the Workforce Shortage?

ABSTRACT Introduction The sonographer workforce shortage is worldwide, with limited access to clinical training positions a major contributing factor to qualified sonographers entering the workforce. Our aim is to examine sonographer training models in English‐speaking countries...

Structural basis of the gating mechanism of the large-conductance mechanosensitive channel from Escherichia coli

Abstract The mechanosensitive channel of large conductance (MscL) is a tension-gated, pore-forming protein that acts as a safety valve to protect bacteria from osmotic lysis. Escherichia coli MscL (EcMscL) was the first mechanosensitive channel discovered and subsequently served...

Understanding bowel cancer screening behaviour and intention across British, Indian, and Indian-Immigrant populations: A qualitative cross-cultural comparison

Bowel cancer screening reduces mortality, yet uptake remains suboptimal across many populations. While disparities in participation are well documented, limited qualitative research has explored how cultural and healthcare contexts shape attitudes towards screening and preventive...

Programmable Anisotropic Terahertz Permittivity via High‐Aspect‐Ratio 3D‐Printed Dielectric Mesh Networks

ABSTRACT We present a 3D‐printed anisotropic dielectric with programmable terahertz permittivity. The design embeds a mesh network of high‐aspect‐ratio void channels within a bulk substrate. The anisotropic electromagnetic response, which depends on the orientation of the void ch...

The freedom to try to do what you want: randomness, organismal agency, and free will

Abstract The world is likely to be indeterministic. As a consequence, agents can never definitely settle anything, because there is always a chance that a random event can interfere with their actions. Yet organisms are able to exploit random processes in order to increase the pr...

Optimizing Gaussian process emulation and generalized additive model fitting for rapid, reproducible earth system model analysis

Abstract. Causes of model uncertainty in complex modeling systems can be identified using large perturbed-parameter ensembles (PPEs), combined with statistical emulators to increase sample size and enable variance-based sensitivity analyses and observational constraint. In global...

The impact of entrepreneurial traits to digital entrepreneurship and international performance: a qualitative analysis of Chinese small and medium-sized enterprises

Abstract This study explores the impact of entrepreneurial traits on the international performance (IP) of Chinese small- and medium-sized enterprises (SMEs) in the digital age. Utilizing a qualitative approach, semi-structured interviews were conducted with Chinese SME entrepren...

The metabokine β-aminoisobutyric acid mediates exercise performance and skeletal muscle adaptation through a PGC1α-BAIBA-PPARδ axis

Abstract Exercise orchestrates an interorgan communication network, in which skeletal muscle releases signaling molecules known as myokines that contribute to exercise training-induced adaptations. We identified the muscle-derived metabolite beta-aminoisobutyric acid (BAIBA) as a...

Enteric pathogens in soil adjacent to public waste bins in Maputo, Mozambique offers potential for environmental surveillance

Abstract Wastewater surveillance has been widely adopted since the COVID-19 pandemic, but non-sewered or onsite sanitation is a common form of sanitation in cities of low- and middle-income countries. Environmental surveillance in these settings requires expanding analyses beyond...

Quantifying temporal changes in the monetary value of forest cultural ecosystem services globally: a meta-analysis

Abstract The world’s forests, and the biodiversity they contain, provide multiple cultural ecosystem services that are essential to people’s well-being. However, interactions between people and forests evolve alongside broader societal and environmental change, raising questions...

Maximizing stem body size may reduce the risk of postoperative periprosthetic fractures

Aims: There is concern around an increased risk of postoperative periprosthetic fracture (POPPF) with cemented polished taper slip (PTS) femoral components. We hypothesized that femoral constructs resulting in increased load on the cement mantle would be associated with higher PO...

How Microscale Flowand Vapor Transport Shape NewParticle Formation and Growth

Abstract Accurate simulation of atmospheric new particle formation (NPF) remains limited because large-scale models cannot resolve aerosol processes at fine spatial scales, while detailed microphysics models assume spatially homogeneous conditions. Here we use a high-resolution t...

Seasonal biogeochemical cycling of permeable sediments in a temperate shelf sea environment

Abstract In highly productive shelf-seas, permeable sediments cover the majority of the benthic environment. However, most research has focussed on shallow environments where currents, tidal flows, terrestrial inputs and benthic productivity have a greater influence than in sedim...

Filtered complexes and cohomologically equivalent subcomplexes

Inspired by Rumin’s work on a subcomplex in sub-Riemannian manifolds that is cohomologically equivalent to the de Rham complex, we present a more general construction that produces subcomplexes from any filtered cochain complex of finite depth and still computes the cohomology of...

Traffic as a social dilemma? Viewing road user behavior through a prosocial lens

Traffic serves as a context where road users engage in various interactions, with the outcomes of these bearing significant implications for the safety of all involved. While traditional research on road user behavior has predominantly focused on risky behaviors, there has been a...

Use, trustworthiness and willingness to self-monitor health and personal wellness: a UK population survey

Abstract Background Public opinion about self-monitoring of health and personal wellness is important but largely unknown. This study investigated public attitudes towards self-monitoring of health and personal wellness. Methods Four thousand two hundred seventy UK adults selecte...