University of Leeds

Understanding bowel cancer screening behaviour and intention across British, Indian, and Indian-Immigrant populations: A qualitative cross-cultural comparison

Bowel cancer screening reduces mortality, yet uptake remains suboptimal across many populations. While disparities in participation are well documented, limited qualitative research has explored how cultural and healthcare contexts shape attitudes towards screening and preventive...

Structural basis of the gating mechanism of the large-conductance mechanosensitive channel from Escherichia coli

Abstract The mechanosensitive channel of large conductance (MscL) is a tension-gated, pore-forming protein that acts as a safety valve to protect bacteria from osmotic lysis. Escherichia coli MscL (EcMscL) was the first mechanosensitive channel discovered and subsequently served...

Programmable Anisotropic Terahertz Permittivity via High‐Aspect‐Ratio 3D‐Printed Dielectric Mesh Networks

ABSTRACT We present a 3D‐printed anisotropic dielectric with programmable terahertz permittivity. The design embeds a mesh network of high‐aspect‐ratio void channels within a bulk substrate. The anisotropic electromagnetic response, which depends on the orientation of the void ch...

Optimizing Gaussian process emulation and generalized additive model fitting for rapid, reproducible earth system model analysis

Abstract. Causes of model uncertainty in complex modeling systems can be identified using large perturbed-parameter ensembles (PPEs), combined with statistical emulators to increase sample size and enable variance-based sensitivity analyses and observational constraint. In global...

The freedom to try to do what you want: randomness, organismal agency, and free will

Abstract The world is likely to be indeterministic. As a consequence, agents can never definitely settle anything, because there is always a chance that a random event can interfere with their actions. Yet organisms are able to exploit random processes in order to increase the pr...

Enteric pathogens in soil adjacent to public waste bins in Maputo, Mozambique offers potential for environmental surveillance

Abstract Wastewater surveillance has been widely adopted since the COVID-19 pandemic, but non-sewered or onsite sanitation is a common form of sanitation in cities of low- and middle-income countries. Environmental surveillance in these settings requires expanding analyses beyond...

Maximizing stem body size may reduce the risk of postoperative periprosthetic fractures

Aims: There is concern around an increased risk of postoperative periprosthetic fracture (POPPF) with cemented polished taper slip (PTS) femoral components. We hypothesized that femoral constructs resulting in increased load on the cement mantle would be associated with higher PO...

Quantifying temporal changes in the monetary value of forest cultural ecosystem services globally: a meta-analysis

Abstract The world’s forests, and the biodiversity they contain, provide multiple cultural ecosystem services that are essential to people’s well-being. However, interactions between people and forests evolve alongside broader societal and environmental change, raising questions...

The metabokine β-aminoisobutyric acid mediates exercise performance and skeletal muscle adaptation through a PGC1α-BAIBA-PPARδ axis

Abstract Exercise orchestrates an interorgan communication network, in which skeletal muscle releases signaling molecules known as myokines that contribute to exercise training-induced adaptations. We identified the muscle-derived metabolite beta-aminoisobutyric acid (BAIBA) as a...

The impact of entrepreneurial traits to digital entrepreneurship and international performance: a qualitative analysis of Chinese small and medium-sized enterprises

Abstract This study explores the impact of entrepreneurial traits on the international performance (IP) of Chinese small- and medium-sized enterprises (SMEs) in the digital age. Utilizing a qualitative approach, semi-structured interviews were conducted with Chinese SME entrepren...

How Microscale Flowand Vapor Transport Shape NewParticle Formation and Growth

Abstract Accurate simulation of atmospheric new particle formation (NPF) remains limited because large-scale models cannot resolve aerosol processes at fine spatial scales, while detailed microphysics models assume spatially homogeneous conditions. Here we use a high-resolution t...

Seasonal biogeochemical cycling of permeable sediments in a temperate shelf sea environment

Abstract In highly productive shelf-seas, permeable sediments cover the majority of the benthic environment. However, most research has focussed on shallow environments where currents, tidal flows, terrestrial inputs and benthic productivity have a greater influence than in sedim...

Traffic as a social dilemma? Viewing road user behavior through a prosocial lens

Traffic serves as a context where road users engage in various interactions, with the outcomes of these bearing significant implications for the safety of all involved. While traditional research on road user behavior has predominantly focused on risky behaviors, there has been a...

Filtered complexes and cohomologically equivalent subcomplexes

Inspired by Rumin’s work on a subcomplex in sub-Riemannian manifolds that is cohomologically equivalent to the de Rham complex, we present a more general construction that produces subcomplexes from any filtered cochain complex of finite depth and still computes the cohomology of...

Use, trustworthiness and willingness to self-monitor health and personal wellness: a UK population survey

Abstract Background Public opinion about self-monitoring of health and personal wellness is important but largely unknown. This study investigated public attitudes towards self-monitoring of health and personal wellness. Methods Four thousand two hundred seventy UK adults selecte...

Bidirectional modulation of psychophysical thresholds in sucrose-bitterant mixtures: sugar reduction and bitterness masking

Reducing sugar content while maintaining palatability remains challenging, particularly when functional ingredients introduce bitterness. However, sweet-bitter interactions are rarely quantified at detection and discrimination thresholds. In this study, we applied a threshold-bas...

Using earth observation for national high resolution dynamic material stock modelling through time; assessing sand consumption in Malaysia from 1989 to 2020

Abstract Understanding the spatio-temporal dynamics of volumes of construction materials is becoming crucial for environmental sustainability and achieving long-term development goals. Whilst direct data collection is always the preferable option it is not always practical. This...

Benefits and challenges of a Patient & Public Involvement (PPI) peer researcher

Involving a patient and public involvement (PPI) peer researcher with lived experience in clinical research is a relatively new concept and to our knowledge, has not been described in adult cardiac surgery. The integration of a PPI peer researcher with a lived experience of a sur...

Extending eFall risk prediction to working-age adults within mental health and learning disability services: a clinical validation study

Abstract Most fall risk tools are developed for older adults; evidence in working-age populations receiving mental health services is limited. To externally validate the existing eFalls prediction model in working-age adults (18–65 years) within a UK integrated teaching National...

Multiscale synergistic design for enhanced energy storage performance in Bi 0.5 Na 0.5 TiO 3 -based lead-free dielectrics under various electric fields

Abstract Dielectric capacitors have been recognized as promising devices for advanced pulse power systems due to their high-power density and fast charge-discharge rates. The dielectrics must simultaneously achieve large energy storage density and high efficiency to support the r...