University of Kansas

A Systematic Review and Meta-Analysis of the Role of Ultrasonography for the Diagnosis of Vesicoureteral Reflux in Pediatric Patients Following Urinary Tract Infections: Technical Report

BACKGROUND: Vesicoureteral reflux (VUR) may be present in as many as 40% of children without known underlying neurogenic bladder or anatomic abnormalities in whom a first urinary tract infection (UTI) is diagnosed. This article reports on a technical review investigating the diag...

Electrospun Nanofiber Therapeutics for Localized Post-Surgical Breast Cancer Treatment

Adjuvant therapy following breast cancer surgery remains challenged by systemic toxicity, poor tumor accuracy, and tumor recurrence. Electrospun nanofibers have emerged to address these concerns. Their high surface area, tunable porosity, and controlled drug release properties en...

Building Open Science Into Graduate Training in Clinical Psychology

Open science promises greater transparency and rigor, yet clinical psychology has lagged in integrating it into graduate training. In this commentary, I build on recent evidence that open-science instruction in U.S. programs remains uneven and largely conceptual. I argue that pro...

Measurements of the production of W$$^{\pm }$$ and Z$$^0$$ bosons in pp collisions at $$\sqrt{s} = 13$$ TeV

Abstract Measurements of the production of the W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons at midrapidity in pp collisions at $$\sqrt{s} = 13$$ s = 13 TeV with ALICE at the Large Hadron Collider (LHC) are presented. The W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons are detected via their (di)e...

Behavioral Interventions in Pediatric Type 1 Diabetes Management: An Updated Meta-Analysis

CONTEXT: The last meta-analysis of behavioral interventions regarding pediatric type 1 diabetes (T1D) management was conducted over a decade ago. OBJECTIVE: This meta-analysis aimed to (1) provide an updated review of adherence-promoting behavioral interventions and their effect...

RheoScale 2.0: Revealing the hidden roles of protein positions via substitution patterns

Abstract A central challenge in molecular biology is understanding how amino acid substitutions modulate various features of protein function and stability. To illuminate the complexities of this relationship, high-throughput (HTP) assays are increasingly used to assess site-satu...

Extreme heat waves favored haboob-generating conditions during the record-breaking “Godzilla” African dust event

Abstract North African dust is frequently transported across the Atlantic to the Caribbean Basin and the U.S.A. in boreal summers, impacting regional weather, climate, and environment. The June 2020 “Godzilla” dust outbreak was the strongest of such events in the last two decades...

The psychosocial impact of neurofibromatosis type 1: a narrative review

Abstract Neurofibromatosis type 1 (NF1) is a rare autosomal dominant (AD) genodermatosis characterized by café-au-lait macules (CALMs), cutaneous and plexiform neurofibromas, and cognitive impairments and neurodevelopmental disorders. As a rare genetic skin disease (RGSD), NF1 is...

Clinical Documentation Completeness in Orofacial Cleft Care Across High-Resource and Surgical Mission Settings: A Cross-Sectional Study

Objective To compare documentation completeness between preoperative records for children with orofacial cleft treated at a high-resource U.S. pediatric center and an itinerant surgical mission program. Design Cross-sectional analysis of a previously published, harmonized 2-cohor...

High-grade astrocytoma with piloid features: a clinical and genomic analysis of prognostic factors using a large cohort

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) is a recently defined tumor type that is not well-understood. Prognostic factors of clinical outcomes are not well-established. METHODS: Methylation profiling was performed on tumor samples, many at the National Cance...

Peptide Fingerprinting of Single Protein Molecules Using In‐Plane Nanopore Sensors Integrated to an Extended Immobilized Nanoscale Enzymatic Reactor (eINER)

ABSTRACT We report a thermoplastic nanofluidic device that combines an extended immobilized nanoscale enzymatic reactor (eINER) with a dual in‐plane nanopore time‐of‐flight (DNP‐ToF) reader for label‐free peptide fingerprinting of single protein molecules. As opposed to tradition...

Safety and Adverse Event Profile of Procedural Sedation for Pediatric Burn Wound Care: A Single-Center Retrospective Cohort Study

Abstract Procedural sedation is essential for pediatric burn care, yet standardized, evidence-based regimens are lacking. This study characterizes the safety profile and pharmacological predictors of adverse events (AEs) in intensivist-led pediatric burn sedations. We conducted a...

Line-Graph Node Centrality in Retrosynthesis

Abstract Molecular structures are naturally represented as graphs in which nodes correspond to atoms and edges to bonds, enabling the application of graph-theoretical and linear algebraic tools to chemical problems. In retrosynthetic analysis, the central challenge is to identify...

Election delay: public support for postponing elections during public health crises

Is it democratic to postpone elections under an emergency situation? Considering the fact that 80 countries around the world postponed elections, this study takes a rare look at citizens’ attitudes toward election delay during a crisis time (the COVID-19 pandemic). Using national...

A Reassessment of Prophylactic Antibiotics in Low‐Infection‐Risk Electrophysiology Procedures

ABSTRACT Certain electrophysiology (EP) procedures are associated with minimal tissue disruption and do not involve permanent transvenous leads. As a result, these interventions carry a lower risk of device‐ or procedure‐related infection. These procedures include placement of im...

SARS-CoV-2 Drug-Resistant Mutations in Non-Structural Proteins

Various antiviral drug therapies have been developed for the treatment of coronaviruses, particularly SARS-CoV-2. However, the emergence of drug-resistant mutations is detrimental to clinical efficacy and global public health. Antiviral usage exerts selective pressures on viruses...

Solvation thermodynamics revisited

Most chemical and biochemical reactions occur in solution; however, many details of the thermodynamics of solvation are not well understood, especially with regard to the role of energy and entropy in the solvation process. Currently, a prevailing view in the field is that the so...

EFN-4/Ephrin converges with SAX-3/Robo, UNC-6/Netrin, and Heparan Sulfate Proteoglycan signaling to control MAB-5/Hox-dependent posterior Q neuroblast migration in Caenorhabditis elegans

Abstract Hox genes have been broadly implicated in nervous system development, but the molecular and genetic mechanisms that act downstream of Hox factors remain to be identified. The MAB-5 antennapedia-like Hox transcription factor is both necessary and sufficient to cause poste...

Beyond the feedback: a student-directed case-based collaborative learning Review committee

INTRODUCTION: The curriculum of the Doctor of Medicine program at The University of Kansas School of Medicine includes a substantial portion of content delivered via small-group, case-based collaborative learning (CBCL) activities. As critical stakeholders in continuous quality i...

Plurality in transformative change: Three co‐created pathways toward nature‐positive Europe(s)

1.The accelerating decline of biodiversity necessitates transformative change to protect nature and society, requiring innovative actions and governance strategies. This paper focuses on developing diverse transformative pathways for biodiversity in Europe and advancing methodolo...