University of Kansas

High-Throughput Screening of a Lipid Nanoparticle (LNP) Library Identifies Lead Formulations for CRISPR-Cas9 Ribonucleoprotein Delivery and Gene Editing

Abstract Delivery of CRISPR-Cas9 ribonucleoprotein (RNP) using synthetic materials can bypass the host translational machinery and limit the duration of genomic exposure, minimizing the risk of off-target mutations. Despite their advantages, lipid nanoparticle (LNP) platforms for...

Fungal frontiers for sustainability: unlocking the hidden kingdom

Fungi have repeatedly delivered transformative advances across industries, from medicine to food to materials, yet these breakthroughs have emerged from a narrow base of organisms and well-studied systems. Although mycology has taken a big leap forward in the past decades because...

Multi-Institutional Data for Faculty Well-Being Improvements Within and Across Medical Schools

Importance Burnout, engagement, and satisfaction vary in prevalence and correlate with organizational performance in US medical colleges. Large-scale improvements have been elusive. Objective To quantify rates of well-being and its organizational correlates so to help identify op...

A Collective Case Study of the Resilience of Student Teachers in the Imperial Valley

Teacher resilience is a dynamic process shaped by personal resources, professional identities, and institutional contexts. Research largely focused on urban settings, leaving unclear how student teachers negotiate resilience in rural borderlands marked by transnational dynamics a...

Highlights from an early base camp in Beringia 13,800 years ago: Shég’ Xdaltth’í’ and the Late Pleistocene peopling of Alaska

Human dispersal across the Bering Land Bridge (BLB) was a key event in the peopling of the Americas, but Beringia’s archaeological record remains poorly understood. In response, the Shég’ Xdaltth’í’ site in interior Alaska has been the focus of a multi-disciplinary study since 20...

Machine Learning on Heterogeneous, Edge, and Quantum Hardware for Particle Physics

The next generation of particle physics experiments will face an era of challenges in data acquisition, due to unprecedented data rates and volumes along with extreme environments and operational constraints. Harnessing these data for scientific discovery demands real-time infere...

Trajectory-Constrained Feature Transformation Optimization Framework for Stable Tabular Data Reprogramming

Tabular data reprogramming is a cornerstone of Data-Centric AI, which seeks to mathematically reconfigure raw features into more expressive and model-efficient representations. This process has traditionally relied on extensive manual engineering. Further, recent automated featur...

The Role of Artificial Intelligence in Research-Based Educational Products

This special issue brings together 11 manuscripts that examine the evolving role of artificial intelligence (AI) in research-based educational products and practices, with particular attention to students with disabilities and the educators who support them. Across empirical stud...

Policing SUD: Constraints and Policy Opportunities

Substance use disorder (SUD) places substantial demands on public safety systems, with law enforcement and other first responders routinely encountering substance use-related harms in daily work. This paper contributes to a growing body of research examining how law enforcement o...

Sleep trajectories in pregnancy: associations with trauma exposure, PTSD, and postpartum depression

Sleep during the perinatal period is often highly disrupted due to maternal biopsychosocial changes that accompany pregnancy. Poor sleep quality is a symptom of PTSD, while insomnia often emerges after a traumatic event and commonly co-occurs with PTSD. Trauma exposure as well as...

Texting for Connection in an “Always-On” Society: Roles of Content, Availability Pressure, and Emotional Fatigue

Texting is the most ubiquitous form of computer-mediated communication, but its ability to satisfy relational needs in an always-on society remains under scrutiny. This study examines how message content and psychological context—specifically emotional fatigue and availability pr...

Occupational and Environmental Hazards in Pediatric Home Healthcare: A Cross-Sectional Study

Background: Home healthcare workers (HHCWs) face challenges related to hazard exposure and disease prevention. The Home Healthcare Environmental Assessment Survey (HHEAS) was developed as a mobile-friendly version of the Home Healthcare Observation tool (HHCWO) to assess occupati...

Linear morphometrics fail to support strong sexual dimorphism in Uintatherium anceps

Uintatheres, mammals belonging to the extinct order Dinocerata, are among the most recognizable of all Paleogene (~66–23 Ma) organisms. Unmistakable for their bizarre skulls with multiple pairs of horns and saber-like upper canines, uintatheres have captivated paleontologists sin...

Medicaid utilization in children: Condition‐specific incidence and spending

Abstract Medicaid insures over half of US children, yet gaps remain in understanding how funds are allocated across the care of nonchronic conditions, the care of chronic conditions, and preventative services. We conducted a retrospective analysis of 7.2 million Medicaid‐enrolled...

Reverb, Chillwave, and the Disinterested Hipster

Abstract This article examines the role of reverb in shaping the sonic and cultural identity of chillwave, a genre that emerged in the late 2000s and became emblematic of the disinterested hipster aesthetic. Focusing on the production techniques in tracks by Washed Out and other...

Development of an Achievable Benchmarks of Care Report Card for Pediatric Hospital Medicine

OBJECTIVES: To develop an Achievable Benchmarks of Care (ABCs) report card for common conditions managed by pediatric hospital medicine (PHM). METHODS: We performed a retrospective cross-sectional study of encounters for 13 common pediatric conditions between January 1, 2023, and...

Projected environmental change relevant to whaling activities in Utqiaġvik, Alaska

The Arctic has experienced rapid change which is projected to continue through the 21st century. These environmental changes may impact traditional subsistence hunting activities including bowhead whale hunting. Here, we present the long term sea ice and wind changes over the 20t...

Near UV Photo-Degradation of IgG1-Fc Promoted by His and Fe(III): Probing the Role of the Metal-Binding Pocket by Site-Directed Mutagenesis

Abstract Light exposure of therapeutic proteins can affect chemical and physical stability and compromise safety and efficacy. In order to develop stable pharmaceutical formulations without undesired side effects, it is essential to understand both product formation and reaction...

The first annotated checklist of the bees of Colombia reveals an overlooked diversity and areas with major data deficiencies

Background Most existing knowledge about bee biodiversity comes from temperate regions, where diversity is presumed highest—yet substantial data gaps across the tropics confound this pattern. Checklists are critical for documenting species presence, identifying knowledge gaps, an...

A Systematic Review and Meta-Analysis of the Role of Ultrasonography for the Diagnosis of Vesicoureteral Reflux in Pediatric Patients Following Urinary Tract Infections: Technical Report

BACKGROUND: Vesicoureteral reflux (VUR) may be present in as many as 40% of children without known underlying neurogenic bladder or anatomic abnormalities in whom a first urinary tract infection (UTI) is diagnosed. This article reports on a technical review investigating the diag...