University of Kansas Medical Center

Magnetic resonance imaging evaluation of oblique injuries: Introduction of the deadrise sign

Oblique injuries are a common sports-related injury to the lateral abdominal wall, most commonly caused by forceful trunk rotation, which tears the internal oblique from the undersurface of the lower ribs. Despite increased awareness and prevention efforts, these injuries remain...

RheoScale 2.0: Revealing the hidden roles of protein positions via substitution patterns

Abstract A central challenge in molecular biology is understanding how amino acid substitutions modulate various features of protein function and stability. To illuminate the complexities of this relationship, high-throughput (HTP) assays are increasingly used to assess site-satu...

Promoting Health Equity Through Tax-Funded Zero-Fare Public Transit: A Survey of Voters From Kansas City, MO

Public transportation has positive impacts for both individual and community health, but funding and scalability are political challenges. Understanding civic processes, such as voting, is key to advancing health equity through large-scale policy change. The purpose of this study...

Primary Pulmonary Low-Grade Fibromyxoid Sarcoma in a 70-Year-Old Woman: A Diagnostic Challenge in Thoracic Spindle Cell Pathology

BackgroundLow-grade fibromyxoid sarcoma (LGFMS) is an uncommon malignant fibroblastic neoplasm characterized by deceptively bland histology and risk of late recurrence and metastasis. Primary pulmonary LGFMS is rare, with fewer than a dozen reported patients. Because the lung is...

Impact of simulated galactic cosmic radiation exposure on ovarian follicle development in mice

Exposure to galactic cosmic radiation (GCR) during deep space missions poses substantial risks to female reproductive (ovarian) and overall health, presenting a fundamental challenge for future exploration missions. To examine ovarian responses, 22-week-old C57BL/6J mice were exp...

High-grade astrocytoma with piloid features: a clinical and genomic analysis of prognostic factors using a large cohort

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) is a recently defined tumor type that is not well-understood. Prognostic factors of clinical outcomes are not well-established. METHODS: Methylation profiling was performed on tumor samples, many at the National Cance...

Safety and Adverse Event Profile of Procedural Sedation for Pediatric Burn Wound Care: A Single-Center Retrospective Cohort Study

Abstract Procedural sedation is essential for pediatric burn care, yet standardized, evidence-based regimens are lacking. This study characterizes the safety profile and pharmacological predictors of adverse events (AEs) in intensivist-led pediatric burn sedations. We conducted a...

A Reassessment of Prophylactic Antibiotics in Low‐Infection‐Risk Electrophysiology Procedures

ABSTRACT Certain electrophysiology (EP) procedures are associated with minimal tissue disruption and do not involve permanent transvenous leads. As a result, these interventions carry a lower risk of device‐ or procedure‐related infection. These procedures include placement of im...

Preliminary Evidence for the Effects of Bilingual ECoLoGiC Treatment for People With Aphasia

Purpose: The focus of this preliminary study is to report the effects of bilingual Expanding Communication and Language Opportunities Generated in Conversation Treatment (ECoLoGiC-Tx) on formal measures of language, functional communication, and patient/family-reported outcomes (...

Integrative Structural Modeling of Intrinsically Disordered Regions in a Human HDAC2 Chromatin Remodeling Complex

Abstract Histone deacetylase-containing complexes play central roles in chromatin regulation, yet the structural organization of their intrinsically disordered regions (IDRs) remains poorly understood. Here, we identify the previously uncharacterized protein C16orf87, which we re...

Responding With Evidence and Access for Childhood Headaches ( REACH ) study: A comparative effectiveness trial of cognitive behavioral therapy monotherapy versus combined cognitive behavioral therapy–pharmacotherapy with amitriptyline for the prevention of childhood migraine—The study protocol

Migraine is one of the most common chronic health problems in children and adolescents, resulting in high levels of functional disability. Symptoms frequently persist into and impact the course of adulthood for affected individuals. Current practice recommendations include a comb...

Beyond the feedback: a student-directed case-based collaborative learning Review committee

INTRODUCTION: The curriculum of the Doctor of Medicine program at The University of Kansas School of Medicine includes a substantial portion of content delivered via small-group, case-based collaborative learning (CBCL) activities. As critical stakeholders in continuous quality i...

Historical Redlining and Spatiotemporal Patterns in Breast Cancer Screening

Importance Geographic variation in breast cancer screening may reflect persistent structural inequities in access to preventive care. Understanding whether historical redlining remains associated with screening, independent of contemporary social vulnerability, neighborhood condi...

An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development

In the developing human placenta, three subtypes of trophoblast cells, cytotrophoblasts (CTBs), extravillous trophoblasts (EVTs), and syncytiotrophoblasts (STBs), mediate critical functions essential for a successful pregnancy. CTBs constitute the stem/progenitor compartment and...

Long-term evaluation of kidney biopsy outcomes to guide continuous quality improvement

Abstract Background Kidney biopsy is essential for diagnosis and management but carries bleeding risks. Efforts to reduce bleeding may compromise tissue adequacy, highlighting the need to systematically evaluate biopsy performance. Understanding factors that influence both safety...

PPARG directs trophoblast cell fate and establishment of the uterine-placental interface

Abstract The expansion and differentiation of trophoblast stem (TS) cells are critical for defining fundamental properties of the placenta. Specialized trophoblast cells called extravillous trophoblast (EVT) cells in human and invasive trophoblast cells in rat, exit the placenta,...

Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study

Background: Laser interstitial thermal therapy is a surgical tool used to ablate brain tumors, radiation necrosis, and epileptic foci. Data from the completed LAANTERN prospective multicenter registry (NCT02392078), containing tumor patients enrolled in the study across 25 US cen...

Use of Skeletal External Fixation to Improve Cultured Epidermal Autograft Outcomes in Lower Extremity Burns

Background: Large surface area burn injuries compromise skin integrity and are associated with significant morbidity and mortality. Skin autografts are essential for wound healing but are limited in patients with extensive burns due to insufficient donor site availability, result...

Prekindergarten and Kindergarten Predictors of Reading Comprehension in Monolingual English and Spanish-English Bilingual Sixth Graders.

PURPOSE: Poor reading comprehension performance by children in the United States is a continuing concern. Early identification and intervention can reduce the number of children with significant reading problems. We documented prekindergarten and kindergarten predictors of Grade...

Impaired but now diagnosable: Combining analytic frameworks for incorporating symptom weighting in the classification of full‐threshold and subthreshold posttraumatic stress disorder

Abstract Individuals with subthreshold posttraumatic stress disorder (PTSD) often experience significant impairment yet face barriers to care (e.g., insurance denials and exclusion from clinical trials) due to strict Diagnostic and Statistical Manual of Mental Disorders ( DSM )–b...