University of Iowa

An Instructional Bottleneck in Learning Limit: An APOS Analysis of Calculus Classroom Practice

This study examines how calculus instruction provides opportunities for students to engage with research-based models of learning the concept of limit. Using genetic decomposition from APOS theory as an analytic framework, we analyze four lessons taught by an experienced instruct...

Pediatric Dentist–Parent Interactions: Converting the Thinking of Practitioners Into Learning Outcomes for Predoctoral Students

BACKGROUND: Effective interaction with parents is indispensable for dentists, yet little literature exists on skillsets or application. PURPOSES: (1) Identify core practices of pediatric dentists when interacting with parents; (2) summarize core practices for use in a skillset fo...

Constructing Algorithmic Authority: How Multi-Channel Networks (MCNs) Govern Live-Streaming Labor in China

This study examines the discursive construction of algorithms and its role in labor management in Chinese live-streaming industry by focusing on how intermediary organizations (Multi-Channel Networks, MCNs) actively construct, stabilize, and deploy particular interpretations of p...

Teaching practices for the civic university: cultivating public good in college classrooms

This study examines how instructional practices can advance the concept of the civic university. This paper conceptualises public goods across five domains: democratic participation, economic growth, knowledge production, sustainability, and holistic development. Through the lens...

Holistic Assessment of Actinide-Borohydride Covalency Using NMR and X-ray Absorption Spectroscopies

Abstract The influence of metal-ligand covalency on actinide electronic properties and reactivity continues to be a topic of intense interest given its implications for nuclear and radiochemical applications. Extensive work has focused on developing spectroscopic methods that can...

Shifting Spaces: The Impact of Instructional Continuity Disruptions and Emergency Remote Learning on Writing Instruction in Secondary Classrooms

The teaching of writing required many shifts during a period of instructional disruption and emergency remote and hybrid instructional approaches as teachers abruptly transformed their instructional practices. In this study, three high school special education and seven English l...

Peace Under the Influence? The Role of Illicit Drug Economies in Peace Processes and Rebel Splintering

How do the economic foundations of rebel groups shape civil war dynamics? While prior research has explored how different resource types affect conflict, less is known about how the illicit nature of certain resources—particularly drug economies—affects peace processes. We argue...

Exposure to chemotherapy alters secondary drug sensitivity without genomic alterations in patient-derived ovarian cancer organoid models

Ovarian cancer has significant morbidity and mortality due to high rates of resistance to chemotherapy and recurrence. Our objective was to deploy patient-derived organoid (PDO) models of ovarian cancer to assess secondary drug sensitivity after exposure to chemotherapy in vitro....

Multimodality Imaging of the Treated Breast

Breast cancer recurrence remains a clinical challenge despite advances in early detection and treatment. In particular, using imaging to distinguish normal posttreatment changes from early signs of recurrence can be difficult. This Pictorial Essay reviews the expected evolution o...

HydroSuite-AI: a web-based LLM environment for hydrological code generation and execution for the hydrosuite open-source ecosystem

Abstract Researchers in hydrology face technical barriers from complex models, evolving libraries, and fragmented documentation. We present HydroSuite-AI, an LLM-based assistant that integrates the open-source web hydrologic libraries HydroLang, HydroCompute, and HydroRTC for cod...

The Positive and Adverse Childhood Experiences (PACE) Framework for Counseling Youths

ABSTRACT Youth mental and behavioral health are significantly shaped by both adverse childhood experiences (ACEs) and positive childhood experiences (PCEs). Yet, counseling scholarship and training often address these domains separately, limiting their translation to counseling p...

Effects of time-restricted eating in early-stage Huntington’s disease: a pilot study

Time-restricted eating (TRE) has shown neuroprotective potential in preclinical models of Huntington’s disease (HD) but has not been tested clinically. Here, we report the results of a 12-week open-label pilot trial ( NCT06490367 ) of 8-h TRE, alongside standard-of-care diet and...

VRFIS: an immersive framework for real-time flood monitoring, visualization, and interactive environmental analysis

ABSTRACT The rapid evolution of Mixed Reality (MR) technologies, particularly Virtual Reality (VR), offers powerful new means of visualizing and interacting with geographic and environmental data. This paper presents Virtual Reality Flood Information System (VRFIS), an immersive...

High-grade astrocytoma with piloid features: a clinical and genomic analysis of prognostic factors using a large cohort

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) is a recently defined tumor type that is not well-understood. Prognostic factors of clinical outcomes are not well-established. METHODS: Methylation profiling was performed on tumor samples, many at the National Cance...

Landscape of approaches for streamlining pre-analytical and early analytical variables for solid tumor next-generation sequencing: A Genomics Organization for Academic Laboratories consortium report

The scope of pre-analytical and early analytical methods used in clinical molecular laboratories can have vast effects on the quality and turnaround time for solid tumor next-generation sequencing assays. To learn more about various approaches, a survey of 24 academic laboratorie...

In vivo CRISPR screening links NFKB1 to endocrine resistance in ER+ breast cancer

Resistance to endocrine therapy (ET) remains a major clinical challenge in the treatment of estrogen receptor-positive (ER+) breast cancer, underscoring the need for novel therapeutic targets. To identify genetic drivers of ET resistance, we conducted an in vivo genome-wide CRISP...

Impact of operative timing for proximal humerus fracture dislocations on development of neurologic injury

Abstract Purpose Operative management of proximal humerus fractures with glenohumeral dislocation is often delayed until a shoulder specialist is available. This study aims to assess whether time from presentation to operative intervention impacts incidence of neurologic injury i...

Engineering hematopoietic stem and progenitor cells to generate red blood cells as viral traps against HIV-1.

. In sum, this work presents a potential strategy for the one-time delivery of CD4-RBC viral traps through autologous transplantation of engineered HSPCs.

Multi-mode design for studying cyber aggression in texts, Facebook and Twitter messages among middle school youth

With the explosion of the internet, cyber aggression has become one of the fastest growing forms of interpersonal violence. Methods used to understand aggressive communications content have been limited primarily to surveys. Here, we present multiple methods - panel surveys, elec...

Actuation of CRP activating region 3 by formylation modulates the Vibrio cholerae response to oxidative DNA damage

The cyclic AMP receptor protein or CRP is a global regulator of bacterial metabolism. CRP activates transcription of genes required for utilization of alternative carbon sources in response to the second messenger cAMP, which is synthesized in the setting of glucose scarcity. Tra...