University of Hawaiʻi at Mānoa

Influence of Precipitation Sources on Pareto-Optimal Parameter Sets and Hydrological Partitioning in SWAT+

Accurate precipitation inputs are essential for watershed hydrological modeling, yet different precipitation datasets may produce similar streamflow performance through different calibrated parameter combinations and hydrological process representations. This study evaluated the...

Phenolic Metabolites as Therapeutics for Chronic Diseases: One Researcher’s PAINS Is Another’s Translatable Polypharmacology

Abstract Phenols, natural and semisynthetic compounds in which a hydroxylated or oxygenated aromatic scaffold is a defining structural feature, occupy a paradoxical position in drug discovery. On the one hand, these compounds are frequently scrutinized for triggering Pan-Assay IN...

Predicting Self-Harm Events After Emergency Department Visits Associated With Mental or Substance Use Disorder Diagnoses

OBJECTIVE: Using a machine learning model, the authors aimed to predict self-harm events within 90 days of an emergency department (ED) visit associated with a mental or substance use disorder diagnosis. METHODS: Electronic health record and claims data of patients ages ≥11 years...

Spectral tuning and signaling of diverse and far red–sensitive rhodopsins in mantis shrimp eyes

Stomatopod crustaceans (mantis shrimps) have extraordinary eyes with unmatched visual rhodopsin diversity, but their potential for broad color detection remains unclear. Here, we report that 17 rhodopsins, mostly from the midband eye region, are involved in color sensing and func...

Machine Learning on Heterogeneous, Edge, and Quantum Hardware for Particle Physics

The next generation of particle physics experiments will face an era of challenges in data acquisition, due to unprecedented data rates and volumes along with extreme environments and operational constraints. Harnessing these data for scientific discovery demands real-time infere...

Insights from more than a year of ongoing episodic lava fountaining at Kīlauea

Episodic lava fountaining is rare globally, with only three occurrences from Kīlauea (Hawaii) since 1823. Beginning in December 2024, an eruption within the summit crater, Halemaʻumaʻu, has produced 54 fountaining episodes to date, each lasting typically for hours and separated b...

Isolation of diverse nontuberculous mycobacteria from Hawai’i feral pigs and identification of Mycobacterium abscessus subsp. bolletii

Abstract Background Nontuberculous mycobacteria (NTM) are environmentally acquired opportunistic pathogens that can cause recalcitrant pulmonary disease, particularly in susceptible individuals. Hawai’i has a high incidence of NTM infections, meriting a better understanding of th...

Formation of Carbonisocyanatidic Amide in Interstellar Ice Analogs as a Candidate Precursor to Prebiotic Pyrimidines

Abstract Understanding how pyrimidine nucleobases form in space is central to prebiotic chemistry, yet the pathways assembling these heterocycles remain unresolved. Carbonisocyanatidic amide (H2NC(O)NCO), an acyclic intermediate with heteroatom connectivity relevant to uracil and...

North Atlantic chlorophyll blooms modulate European hydroclimate and terrestrial productivity

Marine and terrestrial ecosystems are usually treated as separate components of the global carbon cycle, and whether variability in ocean biology reaches plant growth on land has remained unclear. Here we show that phytoplankton blooms in the high-latitude North Atlantic are link...

Development of a Single Thermal Cycling Multiplex RT-qPCR Assay for Rapid Arbovirus Detection

Background: The co-circulation of multiple arboviruses with similar clinical presentations poses a significant challenge for public health surveillance. This study aimed to develop and clinically validate a novel multiplex RT-qPCR assay for the simultaneous detection of five arbo...

Phthalate Pollution and Its Induced Oxidative Stress in the Root–Soil Interface Altering Maize Root-Associated Microbiomes

Abstract Phthalate (PAE) residues adversely affect the root-associated microbiome and growth of plants. However, the pollution-driven alteration in root-associated microbiota and the potential effect factors remain elusive. Here, we systematically investigated the toxic impacts o...

Climate-amplified wildland–urban interface disasters create persistent internal metal mixtures associated with pulmonary impairment

Wildland–urban interface (WUI) wildfires are increasingly important climate-related exposure events because they burn built infrastructure and can mobilize legacy contaminants in addition to generating smoke. Although the acute respiratory effects of wildfire smoke are well descr...

The downward legacy of a phytoplankton bloom in the oligotrophic North Pacific Subtropical Gyre

Abstract Ocean particles are a heterogeneous collection, including living and dead cells, feces, mucus‐rich aggregates, and mineral shells and frustules. In the well‐lit upper ocean, phototrophic processes fuel production of particulate matter; however, only a relatively small pe...

Observed weakening of the Kuroshio driven by the East Asian winter monsoon under ongoing climate warming

Abstract Western boundary currents are generally thought to respond to global warming through basin-scale wind forcing and ocean stratification, yet the role of local winds remains unclear. Here, we investigate changes in the Kuroshio under ongoing climate warming using satellite...

HIP to save: A typology of consumer saving with implications for theory and practice

Abstract After the 2008 financial crisis, the study of saving money skyrocketed among consumer psychologists. The present article seeks to integrate this burgeoning literature by delineating three different types of saving, represented by the acronym HIP: (1) hustling , or saving...

Nonequilibrium Formation of Cyanophosphine (H2PCN)─The Simplest Phosphorus-Containing Nitrile─in Interstellar Ice Analogues

Abstract The detection of phosphorus-bearing molecules along with the high abundance of nitriles in interstellar and circumstellar environments suggests that phosphorus-containing nitriles may form under astrophysical conditions; however, their formation mechanisms have remained...

Framing hotel strategies for demand uncertainty: The asymmetric effects of cancellation policies and F&B incentives

This study examines how hotels manage demand uncertainty through two contrasting strategies: cancellation policies as loss-framed uncertainty reduction tools and food and beverage incentives as gain-framed coping mechanisms. Drawing on prospect theory, we argue that these approac...

L1 word order does not modulate predictive use of dative verb constraints in L2 Mandarin

Abstract This study investigates cross-linguistic influence in L2 prediction: specifically, the hypothesis that first language (L1) speakers of a verb-final language are less likely to use verb information for real-time prediction in a verb-medial (SVO) second language (L2; Şafak...

The role of regulatory focus disposition and trust in hotel booking decisions across different online review websites

Purposes This study aims to examine how customers’ regulatory focus disposition (RFD) and attitudes toward online review websites (ORWs) influence multi-dimensional trust beliefs (ability, benevolence, integrity and informativeness) and hotel booking intention. Design/methodology...

The Translocal Island of Okinawa: Anti-Base Activism and Grassroots Regionalism

When is an island not an island? Shinnosuke Takahashi might agree with Vicente Diaz that “No Island Is an Island” (Vicente Diaz, “No Island Is an Island,” In Native Studies Keywords, ed. Stephanie ...