University of Geneva

The Evolution of Low-ionization Electron Densities in Galaxies across Cosmic Epochs

Abstract We investigate the low-ionization electron density in the interstellar medium (ISM) of galaxies across 0 < z < 8, derived with the [O ii ] λλ 3727, 3730 and [S ii ] λλ 6718, 6733 doublets, using both deep JWST/NIRCam/grism and NIRSpec/MSA spectroscopy. Along with ancilla...

From Biomarker to Bedside: Integrated Care as the Real Innovation in Alzheimer’s Disease

For decades, clinicians treating Alzheimer’s disease could offer accurate diagnosis, symptomatic drugs, and compassionate support, but nothing that altered the course of the disease [...]

Limits of Rauzy graphs of languages with subexponential complexity

To a subshift over a finite alphabet, one can naturally associate an infinite family of finite graphs, called its Rauzy graphs. We show that for a subshift of unbounded subexponential complexity, the Rauzy graphs converge in the sense of Benjamini–Schramm if and only if their emp...

Chronic alanine aminotransferase elevation in people with HIV : Time trends over 22 years and genetic predisposition

Abstract Introduction Chronic elevation of alanine aminotransferase (cALT) is common in people with HIV. Published reports on cALT prevalence time trends have not been uniform. It is unknown whether genetic background is associated with cALT in people with HIV. Methods cALT was d...

Posterosuperior and Anterior Rotator Cuff Repairs Yield Comparable 1‐Year Constant Scores in Routine Clinical Practice: A Propensity Score‐Matched Study From LaTour Group

Purpose To compare clinical outcomes and ultrasound‐assessed healing rates between posterosuperior and anterior rotator cuff repairs using propensity score matching. Methods Consecutive patients undergoing rotator cuff repair between 2015 and 2021 by a single fellowship‐trained s...

PI3Kδ is selectively inhibited by roginolisib by stabilizing the C-terminal helix kα12

Abstract Phosphoinositide 3-kinases (PI3Ks) are major regulators of cell growth, proliferation and signalling, constituting key therapeutic targets in cancer, inflammation, and other diseases. Individual class I PI3K isoforms control key cellular functions, imposing the need to g...

Dopaminergic state modulates shame and contextual emotional responses in Parkinson's disease

Background Shame is frequent in Parkinson's disease (PD) and negatively affects quality of life, yet its dopaminergic modulation remains unclear. Methods We investigated the effect of dopaminergic replacement therapy (DRT) on shame in 41 fluctuating PD patients using an experimen...

Automated Electrostatic Attraction/Repulsion Hydrophilic Interaction Liquid Chromatography Screening for Polar and Charged Analytes in Complex Matrices

Abstract Electrostatic repulsion hydrophilic interaction liquid chromatography (ERLIC) provides unique selectivity for highly polar and charged analytes, yet method development remains challenging. Careful optimization of organic solvent gradients and buffer concentrations is ess...

Breaking the Blend: A multi-tracer kinematic decomposition method for IFS data applied to disentangling the AGN outflow and circumnuclear ring in NGC 5728 with JWST

Abstract Integral field spectroscopy (IFS) of the central kiloparsecs of active galactic nuclei (AGN) reveals a mixture of spatially coincident emission from star-formation and AGN feedback exciting the interstellar medium. Disentangling these components remains a challenge, as m...

Distant water fishing and its effects on domestic food security

Governments around the world have identified distant water fleets (DWFs) as a key threat to ecosystem health, domestic economic opportunities, and food security. With a high prevalence of undernutrition and micronutrient deficiencies in countries where DWFs operate, the aquatic f...

Lifelong health leadership: reframing geriatrics as a model of care for resilient health systems

Abstract Population ageing is commonly framed as a demographic challenge, biological frontier, or economic pressure. Yet these perspectives remain incomplete unless longevity is also understood as a leadership challenge. Gains in lifespan have not been matched by equivalent gains...

Remobilized volcanogenic sediments boost photophysiological activity in three symbiotic reef-building coral species

Abstract Coral reefs that surround volcanic islands are continually influenced by run-off carrying remobilized volcanogenic sediments. Although unaltered volcanic ash is known to supply trace metals that enhance coral holobiont productivity, the impacts of long-term exposure to w...

Is the antihypertensive activity of Hibiscus sabdariffa affected by factors such as origin of the plant and time of decoction? Implications for clinical practice

Abstract Hibiscus sabdariffa is effective against hypertension in clinical trials, with a dose-response effect, making it an important, accessible and sustainable treatment. The aim of the present work was to clarify the influence of origin of Hibiscus on clinical effect and deco...

Early-onset neonatal sepsis and neonatal antibiotic exposure in Hungary a nationwide population-based study

Abstract Neonatal sepsis remains a challenge in perinatal medicine. We aimed to estimate incidence of culture positive early-onset sepsis (CP-EOS), causative pathogens and overall antibiotic exposure in newborn infants in Hungary. Retrospective national registry analysis (2020–20...

Spectra of infinite Cayley graphs, examples with pure band spectra

It is shown that there are groups \Gamma with finite generating sets S such that the adjacency operator of the Cayley graph \mathrm{Cay}(\Gamma,S) is a disjoint union of N intervals, for arbitrarily large integers N .

Phage heteroresistance in clinical Klebsiella pneumoniae isolates: impact of differentiated capsule expression on phage efficacy

Abstract Heteroresistance, commonly described in the context of antibiotics, refers to the presence of resistant subpopulations within a bacterial strain, and is recognized as a likely contributor to treatment failure. Whether population heterogeneity affects phage activity remai...

Simultaneous Inference of Flora‐Wide Nuclear and Plastid Phylogenies Using Angiosperms353 Sequence Capture Data

ABSTRACT Accurate knowledge of phylogenetic relationships and divergence time among plant species composing a regional flora is crucial for understanding the origin of the biodiversity patterns we observe today. Despite advances in phylogenomics, resources available for reconstru...

Orthodontic, regenerative, and implant management of a mandibular anterior defect: 5‐year outcome

Abstract Background Severe alveolar ridge defects in the mandibular anterior region, often associated with congenital tooth absence and subsequent loss of retained primary teeth, present significant challenges for implant rehabilitation. Limited space, horizontal ridge deficiency...

Stimulatrix: An open-source automated platform for high-throughput functional characterization of engineered contractile tissues

Engineered cardiac and skeletal muscle tissues suspended between flexible posts support disease modeling and pharmacology, yet their stimulation, longitudinal imaging and quantitative analysis often remain fragmented and labor-intensive. Here we present Stimulatrix, an open-sourc...

Building digital societies as ecosystems: how recognition and repeat relationships sustain cross-community work in open source

Abstract We measure cross-boundary collaboration in an open-source software (OSS) ecosystem by reconstructing the bipartite contributor–repository graph of 464 cybersecurity-focused projects and $11{,}372$ 11 , 372 contributor identities active over October 2001–May 2022, seeded...