University of Florida

Gibbs measures with multilinear forms

In this paper, we study a class of multilinear Gibbs measures with Hamiltonian given by a generalized U-statistic and with a general base measure. Expressing the asymptotic free energy as an optimization problem over a space of functions, we obtain sufficient conditions for repli...

Combining Contingency Management With Continuous Glucose Monitoring to Support Type 2 Diabetes Prevention and Care

Diabetes prevention and care require recurring self-management behaviors whose benefits are often delayed and uncertain. Digital contingency management (CM), which arranges incentives contingent on objective evidence of behavior or outcomes, offers a scalable way to strengthen th...

COFFlow: Building-Block-Based Generative Modeling for Two-Dimensional Covalent Organic Framework Discovery

Abstract Two-dimensional covalent organic frameworks (2D COFs) are promising porous materials with vast yet largely unexplored design space arising from diverse building blocks (BBs) and crystal topologies. Efficient crystal structure prediction (CSP) and inverse design of 2D COF...

Studying the Mirror Acceleration via Kinetic Simulations of Relativistic Plasma Turbulence

Abstract Efficient relativistic turbulent acceleration of particles is indicated by recent astrophysical observations. The acceleration mechanism due to temporal variations of magnetic field strengths (“Type II mechanism”) remains underexplored. The mirror acceleration has recent...

An Instructional Bottleneck in Learning Limit: An APOS Analysis of Calculus Classroom Practice

This study examines how calculus instruction provides opportunities for students to engage with research-based models of learning the concept of limit. Using genetic decomposition from APOS theory as an analytic framework, we analyze four lessons taught by an experienced instruct...

Non-linear kernel methods for genomic prediction of soybean yield and quality in multi-environment trials

Abstract Key message Nonlinear kernels improve the accuracy of genomic prediction while preserving the inferential framework of quantitative genetics. Abstract Improving the predictive accuracy of genomic prediction (GP) for complex genetic architectures involving non-additive ef...

Integrated internal standard volumetric dried blood microsampling for the quantification of phosphatidylethanol 16:0/18:1

Phosphatidylethanol 16:0/18:1 (PEth) is a direct biomarker of alcohol consumption, formed in red blood cell membrane in the presence of ethanol. Concentrations of 20 ng/mL and 200 ng/mL have been proposed as cut-offs to distinguish abstinence or low alcohol consumption from moder...

The anthropogenic fingerprint on emerging infectious diseases

Abstract Emerging infectious diseases are a hallmark of the Anthropocene 1,2 . Human-driven ecosystem changes and human–wildlife–livestock contact can drive the emergence of zoonotic and vector-borne diseases 3–5 , but how much these processes shape landscapes of outbreak risk is...

Distinct clinical patterns of preterm infants vulnerable to intestinal injury identified by unsupervised clustering

BACKGROUND: Current necrotizing enterocolitis (NEC) diagnostic criteria fail to capture the full spectrum of intestinal injury. We aimed to identify diagnosis-independent clinical patterns of intestinal injury among vulnerable very low birth weight (VLBW) infants using unsupervis...

Coated or chewable Aspirin and a hybrid air pollution mitigation strategy in patients with atherosclerotic disease: Rationale and Design of the COATED-AIR Randomized Trial.

BACKGROUND: Although enteric-coated aspirin is widely used instead of chewable formulations in patients with atherosclerotic cardiovascular diseases (ASCVD), its effects on cardiovascular and gastrointestinal outcomes remain uncertain. Separately, air pollution is a driver of car...

Structural insight into the activation of adenosine A2AR/A2BR by the dual-agonist MRS3997

Abstract A 1 R, A 2A R, A 2B R, and A 3 R adenosine receptors comprise a G protein-coupled receptor (GPCR) subfamily that regulates many bodily processes. Subtype-selective agonists potentially treat inflammatory and ischemic conditions. The dual A 2A R/A 2B R agonist MRS3997 pro...

Medical Journal Editors as Guardrails in Ensuring Research Integrity and Trust in Science

A decline in trust in science, experts and medical research has been accelerating and is at a level that is negatively affecting patient care. Widely disseminated questionable scientific evidence has undermined trust. Peer review within medical journals is designed to safeguard t...

Ceftriaxone versus cefazolin plus gentamicin for antibiotic prophylaxis in Gustilo-Anderson type III open lower extremity fractures

OBJECTIVES: To compare fracture related infection (FRI) rates and outcomes between ceftriaxone (CTX) and cefazolin plus gentamicin (C+G) for antibiotic prophylaxis in Gustilo-Anderson (GA) type III open lower extremity fractures. METHODS: Design: Retrospective cohort study. SETTI...

Controlling Varroa destructor infestations in managed honeybee colonies limits virus spillover into wild pollinator communities

Given recent pathogen-mediated pollinator declines, there is concern regarding virus spillover from managed honeybees to wild pollinators. While the parasitic mite Varroa destructor specializes on honeybees, the viruses it transmits are widespread throughout pollinator communitie...

IBI-DT as a complementary framework for prioritizing candidate genes, interactions, and pathways in congenital heart disease

Congenital heart disease (CHD) has a complex and heterogeneous genetic architecture. Conventional population-level association analyses can identify average genetic effects across a cohort but may miss subgroup-specific, individualized, and interaction-related signals. To address...

Associative Emotional Learning in Convolutional Neural Networks

Abstract Associative emotional learning enables organisms to adaptively link pleasant or unpleasant outcomes to the presence of predictive stimuli. Whereas computational models such as the Rescorla-Wagner model have shed light on this important function, the limitations of these...

Comparative evaluation of 16S rRNA sequencing strategies reveals superior resolution of the healthy Korean salivary microbiome by full-length sequencing

Although next-generation sequencing has elucidated complex microbial networks within the human oral cavity, current analyses remain predominantly limited to genus-level resolution, and most of the human oral microbiome landscape is based on Western population datasets. Because th...

Gut microbiome maturation in early childhood interacts with host genetics to predict type 1 diabetes risk

Prospective evidence linking early-life microbiome development and host genetics with type 1 diabetes (T1D) risk is limited. Here, we describe how gut microbiome maturation and host genetics influence T1D risk in the TEDDY study. We analysed 12,151 longitudinal metagenomes and ho...

Context-dependent transcriptional heterogeneity of new markers expands our understanding of stem cells in Hydractinia

Adult stem cells are found in many animals, particularly invertebrates with high regenerative capacities. The stem cell populations in these organisms can exhibit transcriptional and morphological variation across various spatial and biological contexts. We focus on the adult ste...

An urban evolved invasive plant tolerates experimental climate change

Societal Impact Statement Urbanization may drive invasive species evolution, resulting in greater invasion risks as global conditions change. We compared urban populations of the invasive Erigeron annuus in Zagreb, Croatia, to surrounding rural populations and found that urban‐ev...