University of Florida

Alcohol reshapes liver zonal plasticity and immune-metabolic reprogramming in metabolic-syndrome associated hepatocellular carcinoma

Hepatocellular carcinoma (HCC) commonly arises in metabolic dysfunction-associated steatohepatitis (MASH), alcohol-related liver disease (ALD), and metabolic dysfunction-associated ALD (MetALD), yet how zonal metabolic programs govern tumor lineage and immune responses remains un...

Development and Reliability Testing of the Sinonasal Assessment of Reepithelialization, a Novel Wound Healing Scale to Assess Postoperative Healing

ABSTRACT Background Sinus and skull base surgery create areas of demucosalized bone and cartilage in the sinonasal cavity, yet no standardized system exists to describe the progressive healing of these wounds. The goal of this study was to develop the novel Sinonasal Assessment o...

“There’s No Greater Feeling”: Empowerment and Achievement Through Neurodivergent Co-Design

Extended reality (XR) technologies, including virtual reality (VR), have long been investigated as tools to support autistic and other neurodivergent individuals, yet much of this work has prioritized researcher-defined outcomes over the lived experiences of neurodivergent users....

The Cardiac “Flip” Sign: A Simple Sonographic Marker for “Mirror Image Configuration” of the Great Arteries

ABSTRACT We hereby describe a new sonographic sign, the cardiac “flip” sign, to help in the prenatal detection of a right sided aortic arch with a right sided ductus arteriosus. This sign depends on pattern recognition where the sonologist/sonographer needs to obtain a cardiac sw...

Risk of protein intake deficiency during treatment with GLP-1 and GIP/GLP-1 receptor agonists: considerations for secondary sarcopenia

Sarcopenia, characterized by the age-related decline in muscle mass and strength, increases the risk of falls, fractures, disability, and mortality. Type 2 diabetes and obesity frequently coexist with sarcopenia, contributing to the growing clinical challenge of sarcopenic obesit...

Environmental nitrogen losses in winter wheat across yield zones under long-term precipitation variability

Nitrogen (N) loss dynamics from winter wheat in humid agroecosystems remain uncertain due to variability in soil characteristics across yield zones and high interannual precipitation variability. We hypothesized that dominant N loss pathways vary significantly across yield zones,...

Likelihood‐Based Inference With Separable Correlation Matrices

ABSTRACT This paper proposes methods for likelihood‐based inference in multivariate linear regressions when the correlation matrix of the responses is separable; that is, it has a Kronecker product structure, but the variances are unrestricted. The methods are enabled by a block‐...

AutoEDA: Enabling EDA Flow Automation through Microservice-Based LLM Agents

Electronic Design Automation (EDA) remains heavily reliant on tool command language (Tcl) scripting to drive complex RTL-to-GDSII flows. This scripting-based paradigm is labor-intensive, error-prone, and difficult to scale across large design projects. Recent advances in large la...

Paediatric therapeutic development workshop on osteosarcoma

The fourth Paediatric Therapeutic Development Workshop focused on osteosarcoma, the most common primary bone cancer in children and young adults. Current treatment of osteosarcoma comprises surgery and chemotherapy. Outcome has shown very little improvement over the last four dec...

Baseline Serum Metabolites as Predictors of Teplizumab Response in Individuals With Type 1 Diabetes

Abstract Aims/hypothesis Immunotherapies such as Teplizumab can preserve residual beta cell function in individuals with newly diagnosed type 1 diabetes (T1D), but treatment response is variable. Currently, no biomarker exists to identify individuals most likely to benefit from i...

Dural Puncture Epidural, Standard Epidural, and No Epidural: Comparative Effects on Labor Progression and Neonatal Outcomes

Objective: To compare non-epidural labor, standard epidural analgesia, and dural puncture epidural analgesia with respect to labor progression, obstetric outcomes, analgesia-related outcomes, and neonatal results. Methods: This single-center retrospective observational cohort stu...

Massively parallel characterization of adolescent idiopathic scoliosis risk variants

ABSTRACT Adolescent idiopathic scoliosis (AIS) is a common pediatric musculoskeletal disorder characterized by lateral spinal curvature, often leading to chronic pain and deformity. While a significant genetic component to AIS is recognized, the functional impact of most associat...

MultipathwayAggregation Drives Concentration-DependentAmyloid Polymorphism and Time-Dependent Morphological Evolution

Abstract Amyloid aggregation into polymorphic fibrils is central to many neurodegenerative and systemic diseases, yet the physical origins of fibril polymorphism and time-dependent morphological evolution remain unclear. Because mature fibril morphologies are separated by high en...

Exercise and Brain Health in Postmenopausal Women: A Review of Cognitive Benefits, Mechanisms, and Neurodegeneration Prevention

Menopause represents a major neuroendocrine transition characterized by substantial hormonal, metabolic, vascular, and inflammatory changes that may increase vulnerability to cognitive decline and neurodegenerative disease. Declining estrogen levels during the menopausal transiti...

Development of a Tool to Assess Competency in Bronchoscopic Lung Volume Reduction Via Endobronchial Valve Placement

RATIONALE: Bronchoscopic lung volume reduction (BLVR) is an established treatment option for severe emphysema, improving lung function and quality of life. Despite its growing use, there are no standardized, validated tools to assess operator competency in performing BLVR, limiti...

Tramadol Co‐Administration with Oxycodone or Hydrocodone Increases Opioid Burden without Improving Postoperative Pain Control

Tramadol is frequently co-prescribed with oxycodone or hydrocodone after surgery under the assumption that its dual mechanism of action provides an opioid-sparing benefit. However, evidence supporting this practice is limited and inconsistent. We conducted a secondary analysis of...

Newcomer and Incumbent Exit After Comobility Hiring Events

ABSTRACT Newcomers comprise substantial portions of modern workforces, yet they represent high exit risks due to their lack of embeddedness in their new firms. Organizations often source new employees via comobility, wherein newcomers join simultaneously from another firm. Despit...

More than Infrastructure: How Institutional Frameworks Shape Socioeconomic Value in Toll Roads

Abstract Toll road projects are employed in developing countries to deliver critical infrastructure, fostering socioeconomic development. However, these initiatives often face community opposition because of misalignment between perceived local needs and promised benefits. This s...

Enhancement of cytokine-mediated beta-cell apoptosis by free fatty acids

Type 1 diabetes (T1D) results from dysfunction and loss of the insulin-producing pancreatic β cells. The body’s lipid metabolism is strongly regulated during this process but there is a need to understand how this regulation contributes to the β-cell death. Here, we investigated...

The hematology workforce in the United States: past, present, and strategies for the future

From 2017-2021, the American Society of Hematology (ASH) completed the largest study ever conducted of the hematology workforce in the United States (US). The study highlighted a deficit in the classical hematology (CH) workforce: despite very high CH clinical volumes encountered...