University of Electronic Science and Technology of China

Biological possibility: a mechanistic account

Abstract Current projects in synthetic biology, universal biology, and the origin-of-life study have posed a pressing issue regarding the nature of biological possibility. This essay proposes a novel account of biological possibility, which highlights the role of mechanism: X is...

Brain care score and retinal health: structural and metabolic insights from the UK Biobank

The retina is an extension of the central nervous system and a recognized indicator of systemic health, yet the link between the brain care score (BCS) and retinal health remains unclear. In this study, we aimed to assess the associations of BCS with retinal layer thickness and r...

Preoperative fibrinogen-to-albumin ratio and prediction of muscle-invasive and locally advanced upper tract urothelial carcinoma: development and internal temporal validation of a nomogram

Preoperative staging of upper tract urothelial carcinoma (UTUC) relies on cross-sectional imaging and ureteroscopic biopsy, both with recognised limitations for predicting muscle invasion. We compared the fibrinogen-to-albumin ratio (FAR) with four other inflammation–nutrition in...

Genetic risk factors and causal associations with sudden cardiac arrest

Sudden cardiac arrest (SCA) is a major cause of mortality, with complex etiology involving multiple genetic and environmental factors. In this study, we aimed to identify genetic risk factors for SCA and evaluate their causal associations using Mendelian randomization (MR) analys...

Injective attention neural operators for partial differential equations on large-scale problems

Partial differential equations (PDEs) play a central role in modeling physical phenomena across science and engineering, including fluid dynamics, solid mechanics, electromagnetics, and multiphysics systems. Repeatedly solving PDEs over varying inputs, geometries, and parameters...

177Lu-Labeled Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 Monoclonal Antibody-Targeted Therapy for Clear Cell Renal Cell Carcinoma

Abstract Clear cell renal cell carcinoma (ccRCC) remains a therapeutic challenge. Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) is highly expressed in ccRCC tissues and cell lines, representing a promising target. This study aimed to conjugate lutetium-177 (177Lu) to...

Fe-mediated phase evolution and defect regulation in flexible Cu2Se films for enhanced thermoelectric transport

The monoclinic copper selenide (α-Cu2Se) is a promising thermoelectric (TE) material due to its ordered Cu sublattice and intrinsically low thermal conductivity for near-room-temperature applications. However, excessive Cu vacancies in α-Cu2Se lead to carrier overconcentration an...

PolyAnalysis: a deep learning–based framework for nanopore-based poly(A) tail estimation and 3′-end regulation profiling

Abstract Background Polyadenylation at the 3′ end of mRNA regulates transcript stability, export, and translation, but poly(A) tail length and polyadenylation-site usage remain difficult to resolve from nanopore sequencing data because of homopolymer-associated errors and complex...

Development and validation of a predictive nomogram for stratifying risk in uterine mesenchymal tumors based on clinical and multiparametric ultrasound characteristics

To develop and validate a nomogram model integrating clinical and multiparametric ultrasound features for the preoperative differentiation of uterine sarcoma from atypical uterine leiomyoma. A total of 46 patients with uterine sarcoma and 239 patients with atypical uterine leiomy...

Protocol for detecting germline copy number variants from whole-exome sequencing using agent-assisted Snakemake workflows

Germline copy number variants (gCNVs) are vital for diagnosing rare monogenic disorders. Here, we present a containerized, agent-assisted Snakemake protocol for detecting, annotating, and visualizing gCNVs from short-read whole-exome sequencing data. We describe steps for constru...

Manipulating Crystallization and Deprotonation Reaction through Surface Engineering of ZnO for Bright and Stable Near-Infrared Perovskite LEDs

Abstract Perovskite light-emitting diodes (LEDs) have attracted significant attention owing to their rapidly increasing external quantum efficiencies (EQEs). However, achieving bright and operationally stable perovskite LEDs remains a great challenge. Here, we reveal that the mos...

A Two-Stage Prediction Strategy for Primary Hyperparathyroidism

Background: Primary hyperparathyroidism parathyroid hormone (PTH) hypersecretion is difficult to recognise when calcium is normal and difficult to distinguish from secondary hyperparathyroidism once PTH is found to be elevated. These are separate problems arising at separate poin...

Control of Electronic Properties of Organic–Inorganic MXenes via Surface Functionalization

Abstract Surface terminations critically affect the electronic structure of two-dimensional (2D) transition metal carbides and nitrides (MXenes), yet the synthetic exploration has been hindered by the lack of predictive factors. Here, we establish that the number of lone-pair ele...

Programmable Optical Logic Operations Enabled by Multi‐Wavelength Injection in a Fabry–Pérot Laser

ABSTRACT Photonic spiking neural networks (PSNNs) leverage inherently discrete and event‐driven operations, thereby serving as a promising architecture for optical digital logic. However, limited physical degrees of freedom in current schemes often lead to non‐standardized encodi...

Atomic Scale Origin of the OER Activity–Stability Trade-Off in NiFe Layered Double Hydroxides: Lattice-Site Oxygen Triggers Fe Leaching

Abstract NiFe layered double hydroxide (NiFe-LDH) is a representative non-precious-metal catalyst for the alkaline oxygen evolution reaction (OER), yet its long-term stability is compromised by Fe leaching under OER conditions. Herein, using density functional theory calculations...

A Lovász Theta Bound for a Graph Saturation Parameter

For a finite simple graph G on n vertices, let μ(G) be the minimum trace of a real symmetric matrix X satisfying 0 ≼ X ≼ I, Xᵢⱼ = 0 on the edges of G, and ⟨J,X⟩ = n. We prove that μ(G) ≤ ϑ(complement G) for every G, answering affirmatively question (iii) in Section 7 of Carli Sil...

Double-star labellings of defect one can require arbitrarily many edge-difference changes

For a bijective labelling of an n-vertex tree by 0,...,n-1, define its defect as n-1 minus the number of distinct absolute edge differences. We compare two labellings by counting the fixed edges on which their differences disagree. For every integer s >= 2, we construct a double...

A Lovász Theta Bound for a Graph Saturation Parameter

For a finite simple graph G on n vertices, let μ(G) be the minimum trace of a real symmetric matrix X satisfying 0 ≼ X ≼ I, Xᵢⱼ = 0 on the edges of G, and ⟨J,X⟩ = n. We prove that μ(G) ≤ ϑ(complement G) for every G, answering affirmatively question (iii) in Section 7 of Carli Sil...

Shadow-flow rigidity of D_n polytopes and quartic descent at the 24-cell

For every n >= 4, we prove that the D_n root polytope and its polar have only globally linear odd admissible vertex speeds in every nonzero direction. Admissibility means affine compatibility on every facet transverse to that direction. For the regular 24-cell, every fixed nontri...

Bruhat Monotonicity of the Pan–Skandera–Wang Bijection

Pan, Skandera, and Wang defined a bijection from permutations preserving two balanced consecutive blocks to permutations preserving the parity of every position, and conjectured that each input lies below its image in the strong Bruhat order. We prove Conjecture 7.8 of arXiv:2606...