University of Eastern Finland

Nicotine pouch use induces alterations in salivary metabolites and metabolic pathways. Preliminary study based on NMR spectroscopy

Abstract Introduction Nicotine, a addictive substance in tobacco products, has profound negative impacts on oral and systemic health. This study aims to investigate salivary metabolites and metabolic pathways in nicotine pouch users. Methods This study included 28 participants. O...

Anti-osteoporosis medications in persons with and without Parkinson disease in Finland

Abstract Summary Contrary to reports on under-treatment in persons with Parkinson’s disease, our study found similar anti-osteoporosis medication usage before and after their hip fractures among Finns with and without Parkinson’s disease. Additional preventive measures may be nee...

Comparison of robotic-assisted and manual cochlear implant electrode array insertions considering cochlear geometric factors

Abstract Purpose Purpose of the present study was to compare the intracochlear trauma coincidentally caused by robotic-assisted and manual cochlear implant electrode array insertions in human temporal bones, and to evaluate the influence of cochlear geometry on insertion outcomes...

The Kuopio Idiopathic Normal Pressure Hydrocephalus Protocol Revisited: The Predictive Value of Cerebrospinal Fluid Tap Test

BACKGROUND AND OBJECTIVES: Idiopathic normal pressure hydrocephalus is a condition with gait impairment, incontinence, and cognitive decline, treated with shunt surgery. The Gothenburg scale (GBS) provides comprehensive assessment of symptoms and outcomes. The cerebrospinal fluid...

Negotiated meaning-making under communicative constraints: professionals’ perspectives on paediatric palliative care in mainland China

Paediatric end-of-life care in mainland China occurs within contexts shaped by death taboo, protective silence, and the uneven development of palliative care services. Drawing on interviews with paediatric palliative care professionals, this qualitative study explored professiona...

Toward the Use of Real‐World Data for Regulatory and HTA Decision‐Making: Experiences and Recommendations from Six EU ‐Funded Projects

Real-world data are increasingly important for regulatory and health technology assessment decision-making, yet their effective use across Europe remains limited by technical, methodological, regulatory, and societal challenges. Drawing on the experiences of six Horizon Europe pr...

Carleson measures for weighted Bergman–Zygmund spaces

Abstract For $$0 0 < p < ∞ , $$\Psi :[0,\infty )\rightarrow (0,\infty )$$ Ψ : [ 0 , ∞ ) → ( 0 , ∞ ) and a finite positive Borel measure $$\mu $$ μ on the unit disc $$\mathbb {D}$$ D , the Lebesgue–Zygmund space $$L^p_{\mu ,\Psi }$$ L μ , Ψ p consists of all measurable functions f...

Stakeholder views on recent changes to EU chemicals legislation – are they promoting green transformation or posing challenges for the pharmaceutical sector?

Recent changes to European Union's (EU) chemicals legislation aim to address chemicalisation of the environment and advance green transformation. Although pharmaceuticals are governed by sector-specific legislation and often exempt from certain provisions of chemicals legislation...

Integrative holo-omic data analysis predicts interactions across the host-microbiome axis

Understanding the interplay between host organisms and their microbiomes is central to the development of sustainable food systems. However, high dimensionality and spurious associations remain major obstacles to extracting meaningful biological insight from multi-omic host-assoc...

Epidemiological associations between neurodegeneration and cancer – time to refine our research approach

Cancer and neurodegenerative diseases are devastating aging-related disorders. Epidemiological data suggest a general inverse risk association between them, the mechanisms of which might provide new avenues for developing treatments and prevention strategies. In addition to this...

Researchers Inside the Prison Walls: Methodological and Ethical Reflections on Doing Research With Women in Prison

This article addresses the methodological and ethical challenges in doing research with women in marginalised position in the closed institutional setting of prison. It aims to show that along with formal access issues, it is crucial to acknowledge the positions and complex relat...

Interstitial Fluid Load Support in Human Articular Cartilage: Effects of Degeneration, Loading, and Material Properties via Combined Experimental Testing and Computational Modeling

Abstract Interstitial fluid pressurization plays a key role in cartilage mechanics, as it enables load support, reduces solid matrix stress, and limits solid–solid contact, thereby minimizing wear and friction. Because direct measurement of interstitial fluid load support is chal...

Neuropathology of a patient with Parkinson's disease and biallelic expansion in RFC1

This is the first report of neuropathology in biallelic RFC1 expansion-associated Parkinson's disease (PD). It shows a synucleinopathy of intraneuronal Lewy bodies consistent with the clinical PD diagnosis while neuropathological CANVAS (Cerebellar Ataxia with Neuropathy and bila...

Transmembrane MUC1 assists oral microbial colonization in oral mucosa of potentially malignant disorders and oral squamous carcinoma

Abstract Transmembrane mucin 1 (tMUC1) provides oral mucosal barrier against pathogens. The invasion of oncopathogenic microbes can promote cancerous proliferation of cells via inflammatory responses, abnormal cellular signaling, angiogenesis, anti‐adhesion, and tumorigenesis. Or...

The effect of hyperoxic environment on lung function and myopisation in an extended closed-circuit rebreather diving expedition

Introduction: Repetitive closed-circuit rebreather (CCR) dives subject the human body to a hyperoxic environment. Prolonged oxygen exposure can lead to lung abnormalities and myopic shift. The aim of this study was to analyse the effects of a 31-day period of repeated CCR dives o...

Do social protection expenditures predict female immigrant entrepreneurship? Evidence from the European Union

Purpose In debates on immigrant integration, we move beyond the “welfare magnet hypothesis” by examining whether the host country's social welfare system, as part of its institutional environment, influences female immigrant entrepreneurship (FIE) through mechanisms of risk buffe...

“Everybody loves to hate methodological nationalism”: methodological reflections on moving beyond the nation-state in research design and practice

Surpassing the constraints of methodological nationalism has become one of the main questions in migration studies. Yet the nation-state framework continues to dominate research on migration. In this paper, we draw on two multi-sited fieldworks to discuss how to address methodolo...

α-Latrotoxin and Pain: A Nociceptor Perspective on Latrodectism

Alpha-latrotoxin (α-LTX) is the principal vertebrate-specific neurotoxin in widow spider (Latrodectus) venom and a powerful presynaptic secretagogue. Although its receptors, pore-forming activity and stimulation of neurotransmitter release have been studied extensively in central...

Hip and groin pain in physically active adults with a focus on terminology, clinical examination and imaging: A formal ESSKA‐EHPA‐ESMA Consensus

Abstract Purpose This European Society of Sports Traumatology, Knee Surgery and Arthroscopy–European Hip Preservation Associates–European Sports Medicine Association (ESSKA‐EHPA‐ESMA) formal consensus aims to provide evidence‐ and expert opinion‐based recommendations for the term...

Review of Hypoxemia Quantification Methods for Assessing the Severity of Obstructive Sleep Apnea

Abstract Purpose of Review Obstructive sleep apnea (OSA) is a common nocturnal breathing disorder characterized by recurrent upper airway obstruction during sleep, leading to sleep fragmentation and intermittent hypoxemia. The apnea-hypopnea index (AHI) is the most widely used cl...