University of East Anglia

The Onychomys pangenome reveals the unique molecular adaptations that confer toxin resistance

Abstract Background Predatory grasshopper mice ( Onychomys sp.) have co-evolved resistance to painful and lethal neurotoxins produced by their scorpion prey. Previous studies have reported that structural and functional modifications of the sodium channel Nav1.8 block the effect...

Supporting participatory PhDs: a call to action

Abstract There has been sustained and growing interest in public policy, professional practice, and research, in what has come to be called patient and public, or service user, involvement. Requirements for such involvement are now embedded within health and care legislation, pro...

An International Position Statement on Practical Approaches for Inpatient Continuous Glucose Monitoring, Insulin Pumps, and Automated Insulin Delivery Systems in Adults

There is an urgent and unmet need for a practical clinical guideline addressing the use of continuous glucose monitoring (CGM), insulin pumps, and automated insulin delivery (AID) systems in hospital settings. The goal with this position statement is to facilitate effective and s...

Hidden Morphological Features in Organically Synthesized Porous Carbon Revealed through Analysis of Contradictory NMR Spectra

Abstract A new family of carbon-based materials named “Organically synthesised porous carbon” (OSPC) have proven to have exceptional properties as anode materials in lithium-ion batteries. Experimental X-ray photoelectron spectroscopy characterization has confirmed that the frame...

A disulfide bond sculpts the CTNIP4 phytocytokine fold for recognition by the receptor kinase HSL3

Abstract Precise ligand recognition by closely related leucine-rich repeat receptor kinases (LRR-RKs) is essential for plants to coordinate immunity, development and environmental adaptation. Here we show how the LRR-RK HSL3/NUT specifically recognizes the folded, disulfide-stabi...

Storage treatment and diluent cause inconsistencies in commonly used fluorometric microplate enzyme assays conducted with saltmarsh soils

Abstract Fluorometric enzyme assays are a tool for determining potential enzyme activity in soils. A wide array of methodological approaches is adopted by different studies, making comparisons difficult. An important consideration is whether assay conditions replicate the environ...

Variation dialectale dans la langue favorlang

Résumé Le favorlang était une langue austronésienne de Taïwan, ou formosane, qui est aujourd’hui éteinte. On pense qu’il s’agissait d’une forme ancienne du babuza, qui appartient au sous-groupe des plaines de l’ouest au sein des langues formosanes parlées dans la région centre-ou...

Algal bioactive compounds for next-generation biopesticides: a multi-target resource for sustainable pest management

Abstract The rapid growth in global population and the incessant demand for food warrant greater attention to sustainable agricultural practices. To ensure adequate food security, protection of crops from exposure to biotic agents (e.g., pathogens and insects) is imperative. Over...

Rapid increase of climate extremes reveals new areas of concern in Amazonia

Abstract Amazonia is highly sensitive to climate extremes, yet we lack an Amazon-wide assessment that examines the spatial-temporal changes in these extreme conditions. We address this within seasons and across the hydrological year, using a quantiles approach that integrates the...

Perioperative Interventions to Facilitate Day-Case Vaginal Surgery for Pelvic Organ Prolapse: A Systematic Review

Multiple studies report good outcomes when performing day-case native tissue vaginal surgery for pelvic organ prolapse (POP). Despite this, consensus on optimal perioperative strategies to safely achieve same-day discharge (SDD) remain unclear and no complete protocol has been te...

RUNX2 inhibitor CADD522 improves bone microarchitecture and lipid metabolism in post-menopausal bone loss

Osteoporosis is a leading cause of age-related morbidity, yet existing antiresorptive and anabolic therapies remain limited by safety concerns, contraindications and poor long-term adherence. CADD522 is a small molecule inhibitor of the RUNX2 transcription factor currently under...

Emotional intelligence in managing challenging situations: individual, team and organisational practice

Nursing is an emotionally demanding profession characterised by continual exposure to patient suffering, ethical complexity and high-acuity care, often within resource-constrained environments. These conditions place nurses at heightened risk of stress, burnout and psychological...

Twisted Raman: Orbital Angular Momentum Control of Raman Optical Activity

Abstract Raman optical activity (ROA) conventionally detects differences in Raman scattering associated with opposite circular-polarization states σ, providing a sensitive probe of molecular chirality. Here we show that a different handedness of light can drive ROA: the wavefront...

Genomic response to sex-separated gene pools

ABSTRACT Males and females experience differences in the strength and direction of selection but discerning the type of genes that are targets of sex differences in selection is complicated by their shared genome. We used experimental evolution in Drosophila melanogaster to parti...

Barriers and Enablers to Nurses Routinely Screening for Oropharyngeal Dysphagia in Hospitalised Older Adults: An Evidence Synthesis of Qualitative Studies

ABSTRACT Aim To identify and describe the barriers and enablers to nurses routinely screening for dysphagia in hospital and map these to domains in the Theoretical Domains Framework. Design Systematic review with meta‐ethnography. Data Base Sources CINAHL, Embase, PubMed, Scopus,...

Global HRM and Transnational Networks: Unpacking the Micro‐Behavioral Process Supporting Global HRM Integration Using a Quantitative Multi‐Source, Multi‐Level Design

ABSTRACT Whether and why social processes support global HRM integration is an overlooked, yet increasingly relevant performance question in decentralized transnational work environments. Using social capital theory, we conceptualize the social dynamic and behaviors influencing g...

Refining the Simulation of Mixed‐Phase Clouds Over Coastal Antarctica With a Tailored Ice Nucleating Particle Parameterization

Abstract Climate models have substantial biases in downwelling shortwave radiation over the Southern Ocean (SO) and Antarctica, primarily due to their inability to accurately represent the frequent occurrence of low‐level mixed‐phase clouds. Building on the evaluation of the Unif...

Structural genome variation drives adaptation of the xylose-fermenting yeast Scheffersomyces stipitis to lignocellulosic hydrolysates

Abstract Second-generation (2G) bioethanol from lignocellulosic feedstocks is a sustainable alternative to fossil fuels. However, its production is constrained by the poor performance of industrial microbes in hydrolysates that are generated during biomass pretreatment. Scheffers...

The effect of network degree on bargaining:Experimental evidence from the field

We conduct an artefactual field experiment in real-existing trade networks to analyze how individual network degree affects bargaining demands and outcomes. We combine data from a bilateral bargaining experiment with data of trade networks in 24 villages in Uganda. To identify th...

A genomic catalog of Earth’s bacterial and archaeal symbionts

1 SUMMARY Microbial symbiosis drives the functional and phylogenomic diversification of life on Earth, yet remains underexplored due to culturing challenges. This study employed machine learning (ML) to predict symbiotic lifestyles in hundreds of thousands of microbial genomes fr...