University of East Anglia

P1.200. Reducing Failure to Rescue Improves Long Term Survival After Oesophago-Gastric Cancer Surgery

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Outcomes after oesophago-gastric cancer surgery have improved over time, and this is likely to be multifactorial. In addition to better oncologic treatments, sa...

Concurrent Peripheral Arterial Disease Predicts Re-Intervention Following Abdominal Aortic Aneurysm Repair: A Single-Centre Propensity Matched Retrospective Study

Purpose: Abdominal aortic aneurysm (AAA) and peripheral arterial disease (PAD) share common risk factors and may co-exist in patients undergoing AAA repair. The impact of concomitant PAD on clinical outcomes post AAA repair remains unclear. This study aims to evaluate whether con...

P1.201. Textbook Outcome After Oesophago-Gastric Cancer Surgery: Temporal Change Over 24 Years and Association With Survival

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Outcomes after oesophago-gastric cancer surgery have improved over the last two decades, but it is unclear whether this reflects fewer complications, improved s...

Arming the archipelago: explaining A2/AD divergence in the South China Sea

How do secondary powers develop anti-access/area denial (A2/AD) capabilities when facing asymmetric threats? This article explains variation in Southeast Asian maritime defense strategies through a novel framework that distinguishes between anti-access (A2) and area denial (AD) b...

Genomic catalogue of giant viruses reveals expanded diversity and functional potential

Nucleocytoplasmic large DNA and Mirusviricota viruses exhibit taxonomic richness which continually expands due to metagenomic sequencing. Here we curate a database of giant virus metagenome-assembled genomes (GVMAGs V2), comprising 8,508 species-level representatives from 18,727...

Habitat insularization alters taxonomic and functional beta diversity of understorey birds in Amazonian forest islands

Abstract Habitat fragmentation can profoundly alter the composition of biological communities, modifying patterns of beta diversity among areas. These effects are manifested through different components of beta diversity: differences in richness, which reflect variation in specie...

Retinoic Acid Receptor γ Is a Ligand-Activated Gatekeeper to Stem Cell Developmental Progression

RARγ is expressed during embryogenesis by stem/primitive progenitor cells, indicating a role in controlling their development. Supporting this view is that a physiological level of 10 nM of the RARγ agonist AGN205327 blocked stem/progenitor cell differentiation during zebrafish e...

When education sticks: early imprints and sociopreneurship in emerging economies

This study examines how entrepreneurship education and training (EET) influences sociopreneurship in emerging economies. Drawing on dynamic imprinting theory, we argue that EET received at different stages of life leaves imprints of unequal durability, and that the expression of...

Applying the International Classification of Functioning, Disability and Health to Classify Upper Limb Outcome Measures in Stroke Rehabilitation: A Construct-Driven Perspective

INTRODUCTION: Accurate evaluation of upper limb recovery after stroke is essential for guiding rehabilitation targeting specific impairments and activity limitations. To achieve this, outcome measures must clearly reflect what they assess, whether neuromuscular impairments or act...

Healthcare professionals’ knowledge and experiences of identifying and supporting young carers: a literature review

Young people who have caring responsibilities, usually for a family member, can experience a range of adverse mental and physical health outcomes. Healthcare professionals have a crucial role in providing these individuals with support, however there is inadequate recognition and...

Awake craniotomy for drug-resistant non-oncological epilepsy: a systematic review of feasibility, reported safety, and seizure outcomes

Abstract Introduction Complete resection of the epileptogenic zone offers the best chance of seizure control in patients with drug-resistant epilepsy. However, surgical management remains challenging when the epileptogenic zone is located within or adjacent to eloquent brain regi...

Incidence and relative risk of negative outcomes of psychological interventions for pediatric posttraumatic stress disorder: a systematic review and meta‐analysis of randomized controlled trials

Background Negative outcomes of psychological treatments for pediatric posttraumatic stress disorder (PTSD) have been underresearched. Although reporting has increased over the years, a comprehensive systematic review and meta‐analysis is lacking. Methods We conducted a preregist...

ZPY-CpG-Ch, a broad coverage vaccine against Streptococcus pneumoniae

Existing licensed pneumococcal vaccines, including Prevnar-13 and its higher-valency successors, have played a major role in reducing invasive pneumococcal disease worldwide. However, their effectiveness is increasingly threatened by the rise of multidrug-resistant strains and th...

Evidence-based interventions for vocational recovery in first-episode psychosis: A meta-analysis of employment and education rates

Background: Young people with first-episode psychosis experience high rates of disruption in work and education and consistently describe vocational participation as a core priority of recovery. This meta-analysis aimed to evaluate the effectiveness of evidence-based intervention...

Whole genome comparative analysis shows limited Escherichia coli co-occurrence within co-habiting humans and dogs

Abstract Background Dogs are one of the most popular companion animals in the UK, with an estimated 13.5 million within UK households. Within these households, human-animal physical interactions may lead to inter-species bacterial sharing, including Escherichia coli . E. coli is...

Does Waiver of Informed Consent in Low-Risk Randomised Controlled Trials Improve Research Inclusion? Insights from a Review of the UK Health Research Authority Confidentiality Advisory Group Register

Low-risk pragmatic trials improve clinical services. Informed consent is gold standard to ensure ethical research. However, its implementation can impact participation of underserved groups who face disproportionate barriers around communication, health and research literacy, and...

Synthesis and evaluation of fluorinated chromene-pyridone as a dual-acting agent against Alzheimer's disease and cancer: biological assessment and computational modelling

The global challenge of neurodegenerative diseases and cancer necessitates new multifunctional therapeutics. We designed and synthesised novel chromene-hydrazone derivatives as multitarget ligands. Structures were confirmed spectroscopically and by X-ray crystallography, with dat...