University of Delaware

Comprehensive characterization and translational implications of the GalnsR384C mouse model of Mucopolysaccharidosis IVA

Abstract Mucopolysaccharidosis IVA (MPS IVA) is a lysosomal storage disorder caused by a deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), leading to progressive accumulation of keratan sulfate (KS) and chondroitin-6-sulfate (C6S) and resulting in systemic skeletal...

Adapting to virtual service delivery to increase resilience of domestic violence services

Purpose The rapid shift to virtual services precipitated by the COVID-19 pandemic related restrictions forced domestic violence agencies to alter many types of service provision. A survey of service providers assessed these disruptions and identified services where virtual adapta...

Dispersion fromPolarizabilities of Atoms in Molecule:DPAIM

Abstract A new atom–atom dispersion function DPAIM (dispersion from polarizabilities of atoms in molecules) has been developed. The dynamic polarizabilities, both dipole–dipole and quadrupole–quadrupole, of a set of reference molecules obtained from the time-dependent density fun...

Adaptive oncogenesis of β-catenin emerges from declining liver tissue integrity

Abstract Mutations are fundamental to oncogenesis, yet they cannot fully explain cancer progression, as oncogenic mutations frequently accumulate in healthy tissues without immediate malignancy. In the liver, β-catenin mutations are highly prevalent in hepatocellular carcinoma bu...

Rural Community Perspectives on Hurricane Helene in Western North Carolina

Introduction: After making landfall on the Florida Gulf Coast in September 2024, Hurricane Helene impacted Western North Carolina (WNC) with historic flooding, landslides, and hurricane-force winds. More than 100 deaths in the region were attributed to the storm's direct impacts....

Beyond the Pandemic in Higher Education

This research explores how people in higher education are experiencing long-term recovery from the COVID-19 pandemic. It seeks to hear from members of college and university communities now that we are over five years past the start of the COVID-19 pandemic, including current und...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Advancing boundary-layer physics via Doppler wind LiDAR dynamic-thermodynamic profiling

Simultaneous, high-resolution measurements of boundary-layer dynamics and thermodynamics remain a longstanding observational challenge. We present a Doppler wind LiDAR–based retrieval that derives virtual potential temperature from TKE-budget buoyancy residuals, enabling concurre...