University of Colorado Denver

Efficacy and safety of American ginseng-based therapies for cancer: a systematic review and meta-analysis

Introduction To systematically evaluate the efficacy and safety of American ginseng (AG, Panax quinquefolius L.)-based cancer therapies and assess the certainty of the available evidence. Methods We searched the China National Knowledge Infrastructure, Wanfang, Chinese Scientific...

Fundamental Limits of Transferability and Equivariance in Algebraic Signal Models I: Finite Dimensions

We study the fundamental limits of transferability inalgebraic signal processing through homomorphisms between algebraic signalmodels. Homomorphisms are linear maps between the signal spaces of twomodels that commute with filtering, so filtering a signal and transferringit across...

Prescriptive Target Matching Across Hearing Aid Technology Generations: A Real-Ear Insertion Gain Analysis

Background: Advances in hearing aid technology may improve prescriptive target matching, but whether newer devices better match targets remains unclear. This study compared prescriptive target matching across hearing aid technology generations. Methods: This secondary analysis in...

Comparative Efficacy of Embolic Agents for Single-Session Meningeal Artery Embolization and Surgical Evacuation: Evaluating Liquids, Particles, and Adjunct Coils

BACKGROUND AND OBJECTIVES: Single-session middle meningeal artery embolization (MMAE) combined with surgical evacuation is an emerging strategy for management of patients with chronic subdural hematoma (cSDH). However, comparative outcome data based on embolic material selection...

Interferome profiling in the blood links IFNα5-Mucin-1 axis to HIV-1 pathogenesis

ABSTRACT Type I interferons (IFN-Is) are essential for antiviral immunity, but contribute to immune dysfunction during chronic HIV-1 infection. IFN-Is comprise multiple IFNα subtypes that signal through a common receptor yet exhibit distinct biological activities, but their quali...

Engaging Secondary Caregivers in Research for Children With Medical Complexity

OBJECTIVE: Primary caregivers (PCG; eg, often a parent or guardian) are central to caring for children with medical complexity (CMC). Secondary caregivers (eg, another parent, spouse/partner of the PCG, extended family members, friends, in-home or school-based professionals) also...

Evaluation of the pSOFA Score in a Pediatric Intensive Care Unit and Its Discriminative Performance Compared with PRISM 4 and PIM 3

Objectives: We aimed to evaluate the performance of the age-adapted Pediatric Sequential Organ Failure Assessment (pSOFA) score, as a predictor of mortality in patients admitted to pediatric intensive care units (PICUs), and to compare it with the Pediatric Risk of Mortality 4 (P...

Real-world cardiovascular effects of liraglutide: transportability analysis of the LEADER trial

Abstract Appropriate use of recently approved type 2 diabetes treatments depends on external validity of landmark clinical trials (RCTs) in real-world populations that may differ from trial participants. This study transported effect estimates from the Liraglutide Effect and Acti...

Upfront surgery vs. neoadjuvant therapy in pancreatic cancer with venous involvement: a multicenter retrospective analysis

Abstract Introduction The benefits of neoadjuvant therapy (NAT) for pancreatic cancer (PC) with portal venous involvement remain debated. This study aimed to compare the short- and long-term outcomes of surgery with or without NAT in patients with PC with suspected venous involve...

Women’s Attitudes toward the 2024 US Preventive Services Task Force Mammography Screening Guideline

Background: From 2009 to 2024, the US Preventive Services Task Force (USPSTF) recommended that women aged 40 to 49 y make an informed choice about when to begin having mammograms. In 2024, the USPSTF changed its guidelines, recommending biennial screening from age 40 to 74 y. Thi...

Five years of psychosocial research in audiology: trends, impact, and guidance

Hearing loss affects more than 1.5 billion people worldwide, a figure projected to approach 2.5 billion by 2050, with some 430 million already requiring rehabilitative care (World Health Organizati...

Early life factors documented in electronic health records predict recurrent acute otitis media

Recurrent acute otitis media (rAOM; defined as ≥3 AOM episodes in 6 months or ≥4 episodes in 12 months) affects 10–15% of children in the United States and is a leading cause of healthcare utilization and antibiotic prescriptions. Prospective identification of children at risk of...

Impact of post‐chemotherapy classification on outcomes in stage III and IV unilateral favorable histology Wilms tumor: Pooled data from Children’s Oncology Group AREN0532, AREN0533, and AREN03B2 studies

Abstract Background Improvements in therapy for patients with favorable histology Wilms tumor (FHWT) have relied on refinement of risk stratification for therapeutic assignment through identification of favorable and unfavorable prognostic factors. Although well established in In...

An Fc receptor and IgA functional signature identifies TB disease in children living with HIV

Abstract Background Tuberculosis (TB) is a leading cause of morbidity and mortality among children living with HIV (CLHIV). TB disease is difficult to detect with current clinical microbiological, immunological, and radiographic tools. Serological assays that determine levels of...

Safety Considerations for Hospitalized Children and Adolescents With Obesity

Children and adolescents with obesity make up a growing proportion of hospitalized patients. As a result, pediatric hospital providers are increasingly providing care for patients whose weight meaningfully influences safety during admissions. This review provides practical, evide...

Tobramycin enhances Mycobacterium abscessus fitness through whiB7 induction

Nontuberculous mycobacteria (NTM) are opportunistic pathogens that cause pulmonary disease (PD) in people with bronchiectasis and other chronic airway diseases. Difficulty treating and eradicating NTM-PD highlights the need for improved understanding of bacterial mechanisms to es...

Clinical Characteristics of Enterovirus D68 Respiratory Disease in Colorado Children Over a Decade: 2014-2025

BACKGROUND: Enterovirus D68 (EV-D68) causes cyclical outbreaks worldwide. Though EV-D68 can rarely cause acute flaccid myelitis, it commonly causes respiratory disease. In particular, EV-D68 causes outbreaks of severe asthma-like respiratory disease, but few systems have the capa...

High-grade astrocytoma with piloid features: a clinical and genomic analysis of prognostic factors using a large cohort

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) is a recently defined tumor type that is not well-understood. Prognostic factors of clinical outcomes are not well-established. METHODS: Methylation profiling was performed on tumor samples, many at the National Cance...

The Impact of Tablet-Based Screening on Trichomonas Testing in the Pediatric Emergency Department

OBJECTIVES: Sexually transmitted infections (STIs) are a public health concern for adolescents and young adults, with half of STIs diagnosed annually among 15 to 24-year-olds. Trichomonas vaginalis is a high-prevalence STI, linked with increased risk for HIV and premature births....

Landscape of approaches for streamlining pre-analytical and early analytical variables for solid tumor next-generation sequencing: A Genomics Organization for Academic Laboratories consortium report

The scope of pre-analytical and early analytical methods used in clinical molecular laboratories can have vast effects on the quality and turnaround time for solid tumor next-generation sequencing assays. To learn more about various approaches, a survey of 24 academic laboratorie...