University of Colorado Denver

Engineered Deoxyribonucleic Acid-Tunable Spheroid Platform for Analysis of Tumor-Macrophage Interactions

Abstract Tumor architecture strongly influences immune cell behavior, yet the individual contributions of cell-cell spacing and hypoxia remain difficult to isolate in vivo. Here, we use a DNA-programmable 3D tumor spheroid platform to generate 4T1 spheroids with tunable intercell...

The Therapeutic Potential of Ketamine as a Treatment for Amyotrophic Lateral Sclerosis: A Narrative Review Focusing on Sigma-1 Receptor Modulation, Mitochondrial Function, and Neuroplasticity

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressive motor neuron degeneration. Current Food and Drug Administration (FDA)-approved treatments provide only modest benefits and do not substantially alter disease trajectory, un...

Effect of time to palliative epilepsy surgery on outcomes

Abstract Objective Epilepsy duration is a modifiable risk factor in the outcome of definitive epilepsy surgery; however, an analogous effect in palliative procedures has not been shown. We reviewed the Pediatric Epilepsy Surgery Database data for an association between epilepsy d...

Plain language summary of how acoramidis affects the total number of heart problems over time in people with ATTR-CM: findings from the ATTRibute-CM study

Plain Language SummaryWhat is this summary about?Transthyretin amyloid cardiomyopathy (ATTR-CM) happens when transthyretin (TTR) protein breaks apart, forming clumps that build up in the heart, making it harder to pump blood.People with ATTR-CM often go to the hospital multiple t...

Centering Veteran expertise: advancing peer-led harm reduction in the Veterans health administration

Abstract The principle “Nothing about us without us” underscores the ethical imperative to involve people with lived and living expertise in shaping harm reduction praxis. While the United States Veterans Health Administration (VHA) has expanded harm reduction initiatives, such a...

Reach of Palliative Care in Parkinson Disease: Progress and Gaps After a National Team-Based Implementation Project.

BACKGROUND AND OBJECTIVES: The value of palliative care (PC) is increasingly recognized in the care of people with Parkinson disease (PWP) and their carepartners. While clinical trials demonstrate PC improves quality of life for PWP and carepartners, little is known about the imp...

Evaluation of Cerebral Blood Pressure During Normothermic Regional Perfusion.

Normothermic regional perfusion (NRP) is an effective method for recovering donation after circulatory death (DCD) organs. However, concerns remain that NRP may allow unintended cerebral perfusion despite clamping of the head vessels. This study aims to evaluate cerebral blood pr...