University of Colorado Denver

Infant hippocampal and amygdala volume in an observational follow-up from a randomized clinical trial for maternal prenatal depression

Abstract Prenatal maternal depression may have intergenerational effects on offspring brain development, with potential socioemotional consequences. This observational follow-up study examines brain development and subsequent negative emotionality among 109 infants born to mother...

Change in hearing loss and its association with general health in a community-based longitudinal study of middle-aged individuals: The Busselton healthy ageing study

Introduction With the ageing of the global population, disabling hearing loss is a major health concern. While age and sex are established determinants, the relation between general and environmental health factors and the progression of hearing loss remains incompletely understo...

An Adolescent With Neurosyphilis

Neurosyphilis is a central nervous system (CNS) infection that has become exceedingly rare in the postantibiotic era, especially in children and HIV-negative persons. It can develop during any stage of an untreated syphilis infection and is known as "the great imitator" for its h...

The Effect of Ambient Light on Gait Variability and Joint Biomechanics in Individuals with Unilateral Transfemoral Amputation

Background: Visual input is crucial for stable gait, particularly in individuals with transfemoral amputation (TFA) who lack somatosensory feedback from their TFA limb. Low-light conditions may further influence their walking patterns, increasing the risk of falls and joint disor...

Machine Learning on Heterogeneous, Edge, and Quantum Hardware for Particle Physics

The next generation of particle physics experiments will face an era of challenges in data acquisition, due to unprecedented data rates and volumes along with extreme environments and operational constraints. Harnessing these data for scientific discovery demands real-time infere...

Managing growth and puberty concerns in individuals with Duchenne muscular dystrophy: Updated guidance and future directions

Long-term glucocorticoid therapy is standard of care for individuals with Duchenne muscular dystrophy (DMD) but often results in impaired growth and delayed or incomplete puberty, impacting their physical and psychosocial health. Although DMD endocrine care has evolved, leading t...

Predicting Underweight Status in Infants With Cleft Lip and/or Palate in 10 US Children's Hospitals

ObjectiveTo develop and compare models predicting which infants with cleft lip and/or palate (CL/P) will be underweight at 4 months, using multicenter electronic health record data.DesignUsing data from birth to 3 months, we evaluated 63 anthropometric, clinical, healthcare-utili...

Use of Anticoagulation Among Patients With Atrial Fibrillation or Atrial Flutter in the United States

BACKGROUND: Oral anticoagulation (OAC) remains underused in patients with atrial fibrillation or flutter at high risk of ischemic stroke. We aimed to characterize documented OAC prescribing at diagnosis and during 1-year follow-up and identify factors associated with baseline OAC...

Gut microbial metabolism of peanuts generates immunoregulatory metabolites

Background. Complementary feeding practices and timing are thought to significantly influence early life immune development, with the early introduction of allergenic foods being especially important for prevention of food allergy. We hypothesized that allergen-containing foods s...

Surrogate Decision-Making for Older Adults With and Without Dementia

Importance End-of-life care for older individuals in the US frequently includes interventions that may be burdensome and inconsistent with patient preferences. Few experimental studies have assessed potentially modifiable factors associated with surrogate recommendations. Objecti...

Myeloid cell reprogramming drives enhanced defense against Streptococcus pneumoniae lung infection following exposure to commensal Prevotella

Clinical data link the prevalent respiratory tract anaerobe Prevotella with reduced pneumonia mortality, but the mechanisms directing Prevotella regulation of lung immune homeostasis are unclear. Here, single-cell RNA sequencing was employed to define the transcriptional immune s...

Race and Ethnicity Are Associated With Physical Impairment Among ICU Survivors

Objectives: To evaluate whether race and ethnicity are associated with increased odds of physical impairment among post-ICU survivors and to assess how impairment influences healthcare utilization after hospital discharge. Design: This was a retrospective cohort study. Setting: T...

In silico experiments uncover a novel mechanism underlying mutation rate evolution in sexually reproducing populations

Abstract Natural selection is believed to universally work to lower mutation rates (MR) due to the negative impact of mutations on individual fitness. Mutator alleles can be co-selected by genetic linkage with adaptive alleles in asexual organisms. However, sexual reproduction di...

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

Creation and Validation of the Meaningful Experiences Measure for Museums

A new tool for measuring meaningful experiences in museums was developed, consisting of 15 items that explore various themes integral to meaningful visitor experiences. The tool is unidimensional, which facilitates its practical use by museum researchers for trend analysis across...

GSTT2 Switches from a Homeostatic Antioxidant to a Cell-Cycle-Coupled Factor in Therapy-Resistant Esophageal Adenocarcinoma

Background/Objectives: Glutathione S-transferase theta 2 (GSTT2) is highly expressed in esophageal tissues from African American (AA) compared with European American (EA) individuals, but its localization, regulation, and relevance to esophageal adenocarcinoma progression remain...

Development of an Achievable Benchmarks of Care Report Card for Pediatric Hospital Medicine

OBJECTIVES: To develop an Achievable Benchmarks of Care (ABCs) report card for common conditions managed by pediatric hospital medicine (PHM). METHODS: We performed a retrospective cross-sectional study of encounters for 13 common pediatric conditions between January 1, 2023, and...

Barriers to Reducing Subthreshold Phototherapy for Neonatal Jaundice

OBJECTIVE: In a national, multicenter quality improvement (QI) collaborative to reduce subthreshold inpatient phototherapy, the proportion of subthreshold encounters was high at baseline and remained high after the intervention period. This study aimed to assess why clinicians st...

Right on time: evaluating accuracy and timing of burn-severity assessments to support post-fire management

Abstract Effective wildfire impact assessment and post-fire management rely on burn-severity maps that accurately characterize fire effects on vegetation and soils. These maps inform time-sensitive activities such as post-fire flood and debris-flow modeling, risk mitigation for h...

Efficacy and safety of American ginseng-based therapies for cancer: a systematic review and meta-analysis

Introduction To systematically evaluate the efficacy and safety of American ginseng (AG, Panax quinquefolius L.)-based cancer therapies and assess the certainty of the available evidence. Methods We searched the China National Knowledge Infrastructure, Wanfang, Chinese Scientific...