University of Colorado Denver

Metabolomic profiling reveals distinct and shared biology in COPD and IPF

Chronic Obstructive Pulmonary disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF) are chronic pulmonary disorders with distinct pathologies but shared risk factors. Metabolomics may provide insights into mechanisms. To identify metabolites associated with COPD and IPF, and to...

P1.170. Circulating Biomarkers of Angiogenesis in Esophageal Cancer Patients Undergoing Laparoscopic Gastric Ischemic Preconditioning: A Pilot Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Laparoscopic gastric ischemic preconditioning (LGIP = ligation of the left gastric and short gastric vessels) aims to promote gastric conduit neovascularization and reduce anastomotic leak, a maj...

Diagnosis and management of acute hyperkalaemia

Abstract Hyperkalaemia is a common and potentially life threatening electrolyte abnormality because of its association with malignant cardiac arrhythmias and sudden cardiac arrest. This condition is frequently encountered across acute and chronic care settings and disproportionat...

Empiric MRSA Coverage for Children with Osteoarticular Infections: 2015 to 2024

BACKGROUND AND OBJECTIVES Staphylococcus aureus is the most common causative pathogen for children with acute hematogenous osteomyelitis (AHO) and acute bacterial arthritis (ABA). National guidelines recommend empiric coverage for methicillin-resistant S. aureus (MRSA) at hospita...

Tibial Bone Shape Is Sport Dependent and More Symmetrical in High-Impact Athletes: A Cross-Sectional Study

Introduction: Multidirectional sports introduce unique forces to the tibia that potentially induce more symmetrical distribution of bone mass and lower bone stress injury risk, when compared to unidirectional sports. Purpose: To compare tibial shaft size, shape, and estimated str...

Supporting Children with Medical Complexities: Strengths and Needs in Early Intervention

There is limited research related to Part C Early Intervention (EI) services for families of children with medical complexities (CMC). Given the extensive barriers that CMC and their families experience (e.g., financial hardships, ableism, frequent appointments, mental health pro...

High-Value Care in Pediatric Critical Care: Intravenous to Enteral Gastrointestinal Medications

Advancing pediatric critical care medicine includes identifying and reducing health care costs while maintaining—and even enhancing—the delivery of high-value care. Gastrointestinal (GI) prophylaxis (PPX) is commonly prescribed for children in the pediatric intensive care unit (P...

Variation in In-Hospital Emergency Transfer Rates Across Pediatric Hospitals

BACKGROUND: Clinical deterioration with late escalation, termed emergency transfer (ET), is a key safety metric. However, national benchmarking is limited by variable definitions. We sought to estimate pooled ET rates and assess variation across pediatric hospitals. METHODS: We p...

Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study

Background: Laser interstitial thermal therapy is a surgical tool used to ablate brain tumors, radiation necrosis, and epileptic foci. Data from the completed LAANTERN prospective multicenter registry (NCT02392078), containing tumor patients enrolled in the study across 25 US cen...

Role of the School Nurse in Providing School Health Services: Policy Statement

School nursing has evolved into an essential field bridging health care and education. School nurses play multifaceted roles, addressing direct care, care coordination, public health, leadership, and quality improvement. They manage communicable diseases, chronic conditions, ment...

Characterizing intra- and intertumor heterogeneity in ovarian high-grade serous carcinoma subtypes using single-cell and spatial transcriptomics

Ovarian high-grade serous carcinoma (HGSC) is an aggressive ovarian cancer with a heterogeneous tumor microenvironment (TME). Advances in single-cell RNA sequencing (scRNA-seq) and spatially-resolved transcriptomics have enabled the study of complex TME. This study explores conne...

What’s Old Is New Again: Varicella

The availability of a varicella vaccine has led to significant decreases in incidence of this once-common childhood disease. In the setting of rising vaccine hesitancy, health care clinicians are now more frequently facing questions about infections caused by varicella zoster vir...

Vibrational Spectraof Anionic Polycyclic AromaticHydrocarbons in the CH Stretching Region: Anthracene, Pyrene, Perylene,and Fluoranthene

Abstract The CH stretching region of the infrared spectra of polycyclic aromatic hydrocarbon radical anions (2700–3100 cm–1) is characterized by complicated band patterns that defy straightforward assignments from harmonic calculations. We compare experimental infrared photodisso...

Quantitative computed tomography improves prediction of survival across ILD subtypes

Background Quantitative computed tomography (CT) methods are recognized as valuable tools for risk stratification in fibrotic interstitial lung disease (ILD). Data-driven textural analysis (DTA) is one such approach that correlates with worse lung function and shorter survival in...

Serum Leptin and Thyroid Levels in Hospitalized Patients With Severe Eating Disorders

ABSTRACT Objective Leptin and thyroid hormones are interrelated regulators of energy homeostasis that are altered during starvation, yet their within‐subject trajectories during early nutritional rehabilitation in severe restrictive eating disorders (EDs) remain poorly understood...

Safety and Tolerability of Chronic Carvedilol in Pediatric Dilated Cardiomyopathy: A Report from the Pediatric Cardiomyopathy Registry

Long-term studies on safety of beta-blockers in pediatric heart failure (HF) are scant. We describe the safety profile, dose ranges, and tolerability of carvedilol in pediatric dilated cardiomyopathy (DCM). The Pediatric Cardiomyopathy Registry (PCMR) was used to identify patient...

Coding Errors in Study of Alcohol Use and Obesity

To the Editor We write to report errors in our Research Letter “Heavy Drinking, Alcohol Use Disorder, and Obesity,”1 published online April 20, 2026, and in the June 2026 issue of JAMA Internal Medicine.

Percentiles for crying, regurgitation, stool consistency, and CoMiSSTM in presumed healthy infants

Parents frequently consult health care professionals because of infant regurgitation, crying and stool consistency. The Cow’s Milk-related Symptom Score (CoMiSS TM ) is an awareness tool for cow’s milk allergy. We aimed to characterize the distribution of CoMiSS items in presumed...

Development of an interprofessional education program for aspiration pneumonia care: an action research study

INTRODUCTION/AIM: Aspiration pneumonia has evolved, with demographics shifting to predominantly frail older adults. However, despite the high healthcare impact, there is no established guideline or curriculum for the education and training of healthcare professionals in managing...

The Fertility Reduction Effects of the Colorado Family Planning Initiative by Age and Parity

ABSTRACT We use restricted‐access birth records from the National Vital Statistics System (NVSS) to document the full age and parity fertility effects of the Colorado Family Planning Initiative (CFPI). The CFPI provided access to every FDA approved method of contraception for fre...