University of Cincinnati

Consensus-based clinical and research recommendations for use of glucagon-like peptide-1 receptor agonists in the context of eating disorders: a modified Delphi study.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for type 2 diabetes management and later expanded to obesity treatment, have shown preliminary efficacy in reducing binge eating episodes. However, the appetite-suppressing and weight-loss effects of GLP-1R...

US State Policies on Gender Marker Changes and Fertility Preservation Coverage: Implications for Transgender and Gender-Diverse Health.

. 2026;116(10):1629-1638. https://doi.org/10.2105/AJPH.2025.308380).

Nanoparticle Shape-Templated Peptide Organization Enables Tunable Enhancement of Enzyme Activity

Abstract Biological systems often regulate catalysis by organizing enzymes within dense, multivalent, and nanostructured environments. Nanomaterials can recreate selected features of these environments, but their effects on enzymes range from inhibition to activity enhancement de...

Molecular Machine‐Driven Fluorogenic Probes for Motion–Signal Conversion and Hydrophilicity Retention in Live‐Cell Nanoscopy

ABSTRACT Traditional fluorogenic and cell‐permeable molecular probes for live‐cell nanoscopy mainly rely on structural or hydrophilicity changes to generate intracellular fluorescence signals. Here, we introduce molecular machines into fluorogenic probe design. As a proof of conc...

A Simple Microwave-Assisted Method for the Determination of Boron, Sulfur, Bromine, Chlorine, and Iodine in Whole Blood by ICP-QQQ for Biomonitoring Applications

The simultaneous determination of non-metal elements in whole blood remains analytically challenging because of the complex biological matrix and the wide concentration range. This study describes a simple microwave-assisted alkaline extraction method for the determination of bor...

Body Weight in Relation to the Effectiveness of Intravenous Alteplase in Acute Ischemic Stroke: The ENCHANTED Trial

BACKGROUND: The prognostic significance of body weight in patients receiving thrombolysis for acute ischemic stroke remains uncertain. This study aimed to determine whether body weight modifies the comparative effects of low- versus standard-dose intravenous alteplase and to eval...

Influence of surgical approach on sexual dysfunction following single-level lumbar fusion in men: a propensity-matched analysis

Background Sexual dysfunction represents a meaningful yet understudied complication of spine surgery, with substantial implications for quality of life. Differences in surgical exposure between anterior and posterior approaches may influence these outcomes through variation in an...

From timekeeping to divisions—Molecular links between circadian rhythms and cell cycle

Circadian rhythms and the cell cycle are two fundamental biological oscillators. They are linked through molecular mechanisms creating coupled oscillators where the outcomes of this coupling depend on numerous factors, such as the directionality of coupling (i.e., unidirectional...

Randomized phase II trial of liposomal cytarabine and daunorubicin with or without pomalidomide in newly diagnosed acute myeloid leukemia myelodysplasia-related

Not available.

Lumikine Attenuates Ventilation-Induced Lung Injury in Mice with Lipopolysaccharide-Induced Lung Fibrosis

Lipopolysaccharide (LPS) induces pulmonary fibrosis by increasing microvascular permeability and inducing severe inflammation and extracellular matrix accumulation. Mechanical ventilation (MV), although life-sustaining, can increase inflammatory cytokine production, oxidative str...

Beyond Direct Two-Electron Oxidation: High-Potential Formaldehyde Oxidation on Palladium Still Generates Hydrogen Atoms

Abstract Electrochemical oxidation is typically regarded as incompatible with hydrogen intermediate formation, particularly at highly positive potentials where surface hydrogen species are expected to be rapidly oxidized. Formaldehyde oxidation reaction (FOR) on palladium represe...

Another regularizing property of the 2D eikonal equation

A weak solution of the two-dimensional eikonal equation amounts to a vector field m:Ω⊂R2→R2 such that |m|=1 a.e. and divm=0 in D′(Ω). It is known that, if m has some low regularity, e.g., continuous or W1/3,3, then m is automatically more regular: locally Lipschitz outside a loca...

Spinal interoceptive pathways as therapeutic targets in depression

Interoception is commonly defined as the process by which the nervous system senses, interprets and integrates signals from the body. Converging theoretical frameworks propose that signals about bodily states are conveyed by spinal interoceptive pathways (SIPs) to a distributed i...

Predicting unplanned acute care transfer from an inpatient rehabilitation facility across rehabilitation populations

Risk factors for acute care transfers (ACTs) from inpatient rehabilitation facilities (IRFs) vary by setting and patient population. Prior risk prediction models designed to apply to all IRF patients in an IRF have achieved poor to acceptable predictive value, while better perfor...

Siblings With Duchenne Muscular Dystrophy: Exploring Diagnosis Age and Disease Progression in a Genetic Therapy‐Naïve Cohort

ABSTRACT Introduction Duchenne muscular dystrophy (DMD) is the most common pediatric muscular dystrophy. Typically, there is a ~ 2‐year delay between symptom onset and diagnosis. Limited data on outcomes in early‐diagnosed individuals have limited the understanding of the clinica...

Resolving the biome debate: ecological and palaeo‐data concur that the extensive tree‐limited grassy biomes of central and north‐western Madagascar are largely anthropogenic

ABSTRACT For millennia, human activities have transformed ecosystems globally. Determining which landscapes are predominantly anthropogenic is crucial to conservation and habitat restoration. Madagascar, a critically‐threatened biodiversity hotspot, is a prominent example. Curren...

Do Autistic Adolescents Talk Differently in Same-Sex Versus Mixed-Sex Conversations?

Autistic individuals often struggle with social communication, but the nature of each person’s difficulties varies substantially by context. Recent conversation-based research suggests that males and females (autistic and nonautistic) produce subtle but consistent differences in...

A Causal Model for Prehospital Blood Transfusion and Mortality in Traumatic Hemorrhagic Shock

OBJECTIVES Utilization of prehospital blood transfusion (PBT) as a treatment for traumatic hemorrhagic shock (THS) has been expanding nationally, yet evidence supporting the practice in some operational environments remains limited. Development of strong scientific evidence to su...

A Systematic Replication: Instructive Feedback to Produce Emerging Play Responses

Abstract Social deficits are common in children diagnosed with autism spectrum disorder (ASD). To help facilitate the development of social behaviors, practitioners may target specific play skills, such as with toys. Previous researchers have used discrete trial training (DTT) to...

Probabilistic assessment of supported excavations under demand-based sequential strut loss considering soil spatial variability

Sequential loss of bracing support represents a critical risk scenario in deep excavations, yet its interaction with inherent soil spatial variability and its impact on excavation system reliability have not been systematically quantified. This study proposes a probabilistic fram...