University of Cincinnati

Clinical characteristics and outcome of a cohort of CLL patients with BTK T474 gatekeeper mutation

BTK T474 gatekeeper mutations confer resistance to both commercially approved covalent and non-covalent BTK inhibitors (BTKis) in chronic lymphocytic leukemia (CLL), yet their clinical implications remain poorly characterized. While pirtobrutinib was developed to overcome resista...

From Sensegiving to Sensemaking: TikTok Discourse Surrounding the House Settlement

In June 2025, the House v. National Collegiate Athletic Association (NCAA) settlement was reached, transforming college athletics and athletes’ compensatory rights and opportunities. Utilizing the theoretical coupling of sensegiving and sensemaking, this study explores how the ca...

True Versus Sham Thread Embedding Acupuncture for Spasticity-Related Symptoms and Disabilities in Multiple Sclerosis: Study Protocol of a Randomized Controlled Trial

Introduction: Multiple sclerosis (MS) is a chronic autoimmune disease and one of the most common causes of non-traumatic disability in young adults, with over 2.8 million individuals worldwide. Spasticity affects nearly 80% of people with MS (PwMS), contributing to pain, gait dis...

Differentiating W and W–Sb mineralization in the Xuefeng Uplift, South China: An integrated study of scheelite geochemistry

The Xuefeng Uplift Belt in Hunan Province, South China, represents a transitional metallogenic domain between the Nanling Region and Jiangnan Orogen, hosting a series of Au–Sb–W polymetallic deposits formed under contrasting metamorphic and magmatic-hydrothermal regimes. To eluci...

A scoping literature review of factors associated with burnout among student pharmacists in the United States

Objectives Burnout is an increasing challenge among student pharmacists. Individual studies have examined burnout among student pharmacists; however, faculty and college administrators lack a consolidated understanding of the educational, personal, and contextual factors associat...

Integrating Hereditary Hemorrhagic Telangiectasia into the Diagnostic Workup of Adolescent Heavy Menstrual Bleeding

ABSTRACT To understand the effect of hereditary hemorrhagic telangiectasis (HHT) on uterine bleeding is paramount to improving clinical care of menstruating individuals with HHT. Heavy menstrual bleeding (HMB) in adolescents and young adults (AYAs) with HHT is underrecognized and...

Understanding Remote Monitoring within an Outpatient Setting

Date presented: April 25, 2026 Primary Author and Speaker: Kelly M. Farrell, kelly.farrell2@cchmc.org

Managing growth and puberty concerns in individuals with Duchenne muscular dystrophy: Updated guidance and future directions

Long-term glucocorticoid therapy is standard of care for individuals with Duchenne muscular dystrophy (DMD) but often results in impaired growth and delayed or incomplete puberty, impacting their physical and psychosocial health. Although DMD endocrine care has evolved, leading t...

Glucocorticoid exposure disrupts vascular-immune interactions and impairs steroidogenesis in the fetal mouse testis

Abstract Antenatal corticosteroid (ACS) therapy, typically using dexamethasone (Dex), is a cornerstone of improving preterm infant survival by accelerating lung maturation. However, its systemic effects on other developing organs remain poorly understood. Here, we reveal a previo...

FlexENN: A Graph Neural Network for Binding Energy Prediction of Globular and Intrinsically Disordered Proteins

Abstract Intrinsically disordered proteins (IDPs) drive a large fraction of cellular signaling, transcription, and assembly through interfaces that often lack a defined geometry, making the prediction of their binding energies challenging for methods developed primarily for folde...

Lactation Failure in Postpartum Women Receiving a Dopamine Partial Agonist During Pregnancy

Background Third-generation antipsychotics like aripiprazole can suppress prolactin secretion via the tuberoinfundibular pathway, leading to postpartum lactation failure. This case series assesses the clinical management of this under-recognized postpartum complication in women w...

Association of Diagnosis Age with Clinical Characteristics and MRI Findings in Multiple Sclerosis

Background: Age at multiple sclerosis (MS) diagnosis may be associated with clinical course, inflammatory activity, and disability accrual, but evidence across the full age spectrum remains limited. We compared clinical and radiological features, phenotype distribution, and time...

Analysis of brain iron deposition in an in vivo model of pediatric autosomal dominant polycystic kidney disease

Polycystic kidney disease (PKD) represents one form of chronic kidney disease (CKD) affecting the pediatric population. CKD in early life has been associated with neurocognitive deficits and disturbances in iron metabolism. Excess iron accumulation may exacerbate inflammatory and...

Occupational and Environmental Hazards in Pediatric Home Healthcare: A Cross-Sectional Study

Background: Home healthcare workers (HHCWs) face challenges related to hazard exposure and disease prevention. The Home Healthcare Environmental Assessment Survey (HHEAS) was developed as a mobile-friendly version of the Home Healthcare Observation tool (HHCWO) to assess occupati...

A systematic review of hydrocephalus and psychiatric comorbidities in children and adults with spina bifida

Spina bifida in children and adults is accompanied by substantial psychiatric comorbidity. Hydrocephalus is a common complication of spina bifida and is associated with functional and cognitive deficits, but the role of hydrocephalus in psychiatric comorbidities of spina bifida i...

Comparison of prenatal self-report of tobacco use to direct measurement of umbilical cord cotinine

Abstract Objective This study compared maternal self-reports of prenatal tobacco product use with biochemically confirmed cotinine in umbilical cord tissue in newborns exposed to opioids in utero and unexposed controls. Study design Secondary data analysis on 179 pregnant women a...

Development of an Achievable Benchmarks of Care Report Card for Pediatric Hospital Medicine

OBJECTIVES: To develop an Achievable Benchmarks of Care (ABCs) report card for common conditions managed by pediatric hospital medicine (PHM). METHODS: We performed a retrospective cross-sectional study of encounters for 13 common pediatric conditions between January 1, 2023, and...

Anticoagulation Treatment Response Among Phenotypic ESUS Clusters: Evidence From CASPR

ABSTRACT Objective To evaluate treatment effect heterogeneity across phenotypic clusters of patients with cryptogenic embolic stroke using causal inference methods. Methods From a retrospective, multicenter cohort of patients with cryptogenic embolic stroke, we estimated the trea...

Consensus-based clinical and research recommendations for use of glucagon-like peptide-1 receptor agonists in the context of eating disorders: a modified Delphi study.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for type 2 diabetes management and later expanded to obesity treatment, have shown preliminary efficacy in reducing binge eating episodes. However, the appetite-suppressing and weight-loss effects of GLP-1R...

The Childhood Liver Disease Research Network's prospective characterization of pediatric primary sclerosing cholangitis.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a rare biliary fibrosing disease that leads to significant morbidity and the need for liver transplantation. The Childhood Liver Disease Research Network is conducting a prospective, observational longitudinal study to define th...