University of Chinese Academy of Sciences

Recent advances in universal influenza vaccine platforms: paving the way for universal H5N1 vaccines and pandemic readiness

Abstract The H5N1 influenza threat is a significant issue to the overall health of the population in the world, and it demands new approaches in vaccine development and implementation. The critical path forward is the development of universal vaccine platforms, which provide long...

Mitochondria-Targeted Prodrug Nanoassemblies Elicit Antitumor Immunity via Mitophagy-Boosted Ferroptosis in Triple-Negative Breast Cancer

Abstract Ferroptosis, an immunogenic iron-dependent cell death driven by lipid peroxidation, holds promise for treating triple-negative breast cancer (TNBC). However, its efficacy is severely compromised by restricted iron availability and the potent GPX4/GSH defense system. Here...

Physics-informed neural network for modeling coupled fluid flow and heat transport in a geothermal doublet system

Geothermal energy is an important renewable energy resource, and geothermal doublet systems are widely used for its sustainable exploitation. Accurate simulation of coupled fluid-flow and heat-transfer processes in geothermal doublet systems provides an important basis for assess...

Spaceborne multi-sensor tracking reveals hydrologic decoupling during the record-breaking Sahara flood

Satellite remote sensing enables large-scale quantification of extreme hydrologic events in data-scarce regions, yet the integration of multi-sensor observations to resolve hydrologic responses remains limited. The record-breaking 2024 Sahara flood presents a unique opportunity t...

A comprehensive review of an artificial intelligence-based framework for classifying and solving modified heat partial differential equations

Partial differential equations (PDEs) fundamentally describe the dynamic relationships among physical quantities and therefore play an essential role in modelling physical processes such as heat transfer, fluid flow, population dynamics, and material behavior, unlike purely algeb...

Single-scene thin-cloud correction for dynamic macroalgal blooms via water-referenced radiative transfer

Thin clouds substantially attenuate spectral signals in satellite imagery, leading to systematic underestimation of macroalgal bloom coverage. Existing thin-cloud correction methods have critical limitations for dynamically drifting blooms: they typically require paired cloudy-cl...

Single-photon controlled phase shifts with colloidal quantum dots at room temperature

Quantum logic gates based on quantum electrodynamics (QED) in strong coupling regime between quantum dots and microcavities are key elements for scalable quantum computing and all-optical quantum networks. Here, a single colloidal quantum dot was site-selectively positioned onto...

Resource utilization and phenological dynamics in underground-aboveground parts of Rheum tanguticum via metabolomics and microbiomics

Abstract Rhubarb, a globally important perennial herb, possesses considerable pharmaceutical and food potential. Using Rheum tanguticum as plant material, this study systematically profiled the metabolomic and endophytic communities of its roots, petioles, and leaves across diffe...

RL-Axial: Learning When to Compute Global Context for Multimodal Segmentation

High-resolution remote sensing semantic segmentation is a key enabler for fine-grained urban mapping and related geospatial applications. However, complex textures, severe scale variations, and cross-modal discrepancies make models with fixed architectures and computation paths s...

The impact of HfO2 dielectric layers deposited at different temperatures on performance and reliability of hydrogen-terminated single-crystal diamond MOSFETs

Gate dielectric plays a critical role in determining the electrical performance and stability of hydrogen-terminated diamond (H-diamond) Metal Oxide Semiconductor Field Effect Transistors (MOSFETs). This work systematically investigates the influence of HfO 2 dielectric layers de...

Enantio- and Regioselective Ni-Catalyzed Hydroarylation of Alkenes and Alkynes to Form C–N Axially Chiral Heterobiaryls

Abstract C–N axially chiral heterobiaryls are highly valuable yet synthetically challenging scaffolds. Atroposelective hydroarylation represents an ideal strategy for their construction, offering both high step- and atom-economy. Herein, we report an enantio- and regioselective N...

Construction and Application of an Integrated “Chemical–Biological” Dual‐Core Quality Evaluation System for Salvia miltiorrhiza

ABSTRACT Background and Aim Practical implementation of integrated chemical–biological quality control in Traditional Chinese Medicine (TCM) remains challenging. This study used Salvia miltiorrhiza as a model to develop an exploratory integrated quality‐evaluation strategy that c...

Tuning the Lifetime and Spectral Readout of Single-Atom Magnets with a Vector Magnetic Field

Abstract Magnetic atoms on insulating films are promising candidates for information storage at the atomic scale, but practical operation requires their magnetic lifetimes and readout to be controllable. Here, we study holmium (Ho) single-atom magnets on MgO using electron spin r...

Influence of Mg concentration in the AlGaN electron blocking layer on the temperature response of GaN-based near-UV laser diodes

Temperature responses of the output characteristics of GaN-based near-UV laser diodes (LDs) with different Mg concentrations in the AlGaN electron blocking layer (EBL) were numerically investigated over the temperature range of 300–360 K under an ideal-interface assumption. The r...

Functional division between root endosphere and rhizosphere microbiomes supports seagrass holobiont resilience under high nutrient and sulfide exposure

Coastal eutrophication leads to the co-occurrence of high nutrient loading and sulfide exposure, posing severe threats to the health of seagrass ecosystems. Yet the underlying adaptive mechanisms of the seagrass holobiont remain poorly understood. Here, we conducted a large-scale...

Water‐Mediated Reversible Crystalline Phase Transformation Enables Color Switching and Circularly Polarized Luminescence Handedness Inversion

ABSTRACT Stimuli‐responsive circularly polarized luminescence (CPL) modulation is highly sought for adaptive chiroptical systems, yet achieving reversible CPL handedness inversion in crystalline solids remains challenging. Here, we report organic ionic crystals composed of lumine...

Spectral analysis for magnetohydrodynamic channel turbulence at low magnetic Reynolds number

In this study, direct numerical simulations were conducted to investigate turbulent channel flow under the influence of a spanwise magnetic field, at a friction Reynolds number italic Re Subscript tau Baseline equals 180 Re τ = 180 $ \textit{Re}_{\tau } = 180$ and Hartmann number...

Automated morphometric modelling of an endangered freshwater cetacean from unscaled UAV imagery using an internal scaling framework

With the rapid advancement of drone technology, aerial photogrammetry has been increasingly applied to morphometric research, particularly for endangered species, owing to its fully non-invasive nature. Photogrammetry-derived morphometric models (e.g., three-dimensional reconstru...

SQQ: Python Joint Toolkit for Water-Shell Topology Analysis

Abstract Order parameters are essential for molecular dynamics structures of crystalline water, as they provide quantitative measures of phase change. Yet conventional descriptors cannot directly resolve water-ring connectivity, face adjacency, or cage closure. Here, we develop t...

Quantum Uncomputation of Clean and Dirty Ancilla Qubits

Automatic uncomputation aims to provide programming-language-level support to facilitate the correct and safe use of ancilla qubits in quantum computing, but efforts have only been made for clean ancillas, leaving dirty ancillas unexplored. We present a unified formalization of t...