University of Chinese Academy of Sciences

CDSB: accelerating connectomics workflow via Content-Decoupled Schrödinger Bridge

Abstract Background Large-scale connectomics requires the nanometer-scale resolution of electron microscopy to resolve ultrastructural details, but its acquisition is time- and labor-intensive. In contrast, high-throughput light microscopy offers high throughput but lacks the spa...

Cryo-EM structures of Cdr1 reveal snapshots of substrate transport and diverse inhibitor recognition

In Candida albicans —a World Health Organization fungal priority pathogen—overexpression of the adenosine triphosphate (ATP)–binding cassette transporter Cdr1 drives multidrug resistance. We present seven cryo–electron microscopy structures capturing substrate entry and expulsion...

Application and prospect of artificial intelligence in biochar for acidic soil amelioration

Abstract Effective amelioration of acidic soils with biochar is critical for mitigating soil degradation and promoting sustainable agriculture, yet this requires robust mechanistic understanding and predictive modeling. This review synthesizes the key biogeochemical pathways by w...

Identification and characterization of ethR and ethA genes impacting the sensitivity of Mycobacterium abscessus to ethionamide

ABSTRACT Mycobacterium abscessus is a rapidly growing non-tuberculous mycobacterium with rising global incidence. This pathogen exhibits intrinsic resistance to most antibiotics, presenting a major public health threat. Ethionamide (ETH) requires bioactivation by monooxygenase Et...

Statistics-enhanced cross-domain perception network for spaceborne infrared tiny ship detection

Spaceborne thermal infrared remote sensing is indispensable for maritime surveillance and ship management, yet detecting tiny ships in infrared imagery remains challenging due to small object sizes, weak textures, and strong structured clutter. To address these challenges, we pro...

In-orbit test of the weak equivalence principle with atom interferometry

The weak equivalence principle (WEP) is a central pillar of general relativity. Its precise test with quantum systems in space offers a unique window onto new physics. Here, we report an in-orbit quantum test of the WEP. A dual-species ( 85 Rb/ 87 Rb) atom interferometer is reali...

High‐Efficiency Acousto‐Optic Modulation on Non‐Suspended Thin‐Film Lithium Tantalate

ABSTRACT Acousto‐optic (AO) interactions provide a powerful interface between the microwave and optical domains, enabling optical switching, non‐reciprocal propagation, and efficient microwave‐to‐optical transduction. Here, we demonstrate high‐efficiency AO modulation on a non‐su...

Ultralow‐Dose Direct Photopatterning of Metal–Organic Frameworks for Scalable Device Integration

ABSTRACT The integration of metal–organic frameworks (MOFs) into microelectronic and optoelectronic devices requires patterning strategies that combine high sensitivity, structural preservation, and compatibility with scalable fabrication. Direct optical patterning offers a photo...

Genomic predisposition is associated with the direction of sex chromosome evolution

Sex chromosome evolution is among the most dynamic genomic innovations in vertebrates, yet why some lineages evolve XY while others evolve ZW remains unclear. Using chromosome-level genomes from 19 geckos, we found that gecko sex chromosomes originated independently from 16 ances...

How Norms Depend on the Presence and Status of Observers: The Relational Contingency of Everyday Behaviors in 90 Societies

Norms are fundamental to social life, but basic questions about how they are affected by social context remain. Specifically, how do normative constraints depend on the presence and status of observers, and how do such relational contingencies vary across cultures? Using data fro...

PRISM: Feature-Guided Hierarchical Inpainting for Dual-Band Infrared Defective Pixel Clusters

This paper presents a feature-level defective pixel cluster (DPC) correction method specifically designed for dual-band infrared detectors. Due to inherent manufacturing limitations, antimonide-based type-II superlattice (T2SL) focal plane arrays (FPAs) commonly suffer from DPC i...

A Time-of-Flight Neutron Backscattering Spectrometer at the China Spallation Neutron Source: Principle, Design, and Its Prospects

The quasielastic neutron scattering technique is an indispensable tool for probing microscopic dynamics in condensed matter at the nanoscale. However, the lack of a high-resolution spectrometer has restricted comprehensive studies of dynamics in China. To address this gap, a new...

Complete genome-derived metabolic interactions reveal the impact of gut ecology on human health

Abstract Metabolic interactions govern gut microbiome assembly, yet functional rules remain obscured by genomic incompleteness and fragmentation. Here, we leverage 1,150 complete genomes to construct genome-scale metabolic models, demonstrating that draft genomes introduce system...

Meta‐Learning‐Enhanced Implicit Full Waveform Inversion

ABSTRACT Implicit full waveform inversion (IFWI) introduces implicit neural representations to parameterize the subsurface velocity model as a continuous function of spatial coordinates, which alleviates the dependence on the initial model and improves inversion flexibility. Howe...

The 2024 cascading glacial lake outburst flood in the Thame Valley of Everest region, Nepal: process, impacts and implications

Abstract. On the afternoon of 16 August 2024, a catastrophic flood devastated Thame Village in the Everest region of Nepal. This event resulted from a cascading glacial lake outburst flood (GLOF), where the outburst of an upstream glacial lake triggered the failure of a downstrea...

Elastic Liquid Metal Foam for Self‐Powered Triboelectric Sensing and Intelligent Tactile Recognition

ABSTRACT With the rapid expansion of the Internet of Things (IoT) and artificial intelligence (AI), developing flexible self‐powered electronic skins with high sensitivity and mechanical robustness has become a critical research priority. However, traditional metal‐polymer compos...

Direct evaporation of single-crystal metal contacts for 2D semiconductors

Metal contacts remain one of the key bottlenecks in two-dimensional (2D) semiconductor electronics. We developed an atomic-scale step-by-step evaporation method to directly grow single-crystal metals on monolayer semiconductors with clean interfaces. This method accesses a distin...

On the simplicity of de Sitter correlators

A bstract Motivated by recent evidence that equal-time correlators can be simpler than the corresponding wavefunction coefficients, we study de Sitter correlators in conformally coupled ϕ 3 theory directly. By inverting the momentum-space dressing rules, we derive a time integral...

Anisotropy of Satellite Galaxies. I. Contrasting Correlations with Central Galaxy, Host Halo, and Large-scale Filament Structures

Abstract Using the SIMBA, EAGLE, and IllustrisTNG-100 galaxy formation simulations, we examine the anisotropy of the satellite distribution and its dependencies on central galaxies, host halos, and cosmic filaments. We find that in all simulations, the satellite anisotropy is rob...

Unveiling the nexus between products and influential countries in the multi-layer trade network of global lithium battery

Amid the accelerating global transition to renewable energy and the surge in electric vehicle adoption, ensuring the stability of the lithium battery supply chain has become a critical priority. This study explores the complex relationships between products and influential countr...