University of Campania "Luigi Vanvitelli"

Real-world effectiveness and drug retention rate of risankizumab in patients with psoriatic arthritis: data from the multicentre GIRRCS cohort

Introduction Psoriatic arthritis (PsA) is a chronic heterogenous inflammatory disease characterized by a multidomain burden. Risankizumab, a selective inhibitor of the IL-23 p19 subunit, has shown efficacy in randomized trials; however, real-world data in PsA remain limited. We e...

Lichen-Derived Bioactive Compounds in Diabetes and Cardiovascular Risk: Experimental Evidence, Mechanisms, and Translational Challenges

Cardiometabolic disorders arise from interconnected metabolic, inflammatory, oxidative, mitochondrial, and vascular abnormalities. Lichens produce structurally diverse secondary metabolites, including depsides, depsidones, dibenzofurans, anthraquinones, and other phenolic compoun...

False Friends of Sustainable Mobility: A Fork-to-Wheel Method for Human Metabolic Energy in the Life-Cycle Carbon Footprint of Passenger Transport in Italy

Transport is among the hardest sectors to decarbonize, yet life-cycle carbon-footprint (CF) assessments of mobility systematically omit the human metabolic energy expended while traveling. This study introduces a Fork-to-Wheel system boundary that incorporates metabolic energy ex...

Sphingolipid Remodeling and Extracellular Vesicle Signatures Reflect Disease Severity in Facioscapulohumeral Dystrophy Driven by Mitochondrial Dysfunction and Endoplasmic Reticulum Stress

Background: Facioscapulohumeral muscular dystrophy (FSHD) is a progressive and heterogeneous disorder lacking reliable circulating biomarkers for disease monitoring and therapeutic response. We hypothesized that metabolic dysregulation, lipotoxicity, and endoplasmic reticulum (ER...

Telerehabilitation for Motor Recovery in Adults with Neurological Disorders: A Systematic Review and Meta-Analysis Across Motor Domains, Delivery Models, and Follow-Up Effects

Background/Objectives: Telerehabilitation may extend neurorehabilitation beyond conventional settings, but comparative effects across neurological diagnoses and motor domains remain uncertain. This systematic review and meta-analysis synthesized motor outcomes while distinguishin...

The Mast Cell–Substance P Neuroimmune Axis in Allergic Contact Dermatitis and Atopic Dermatitis: Molecular Mechanisms and Pathophysiological Perspectives

Recent advances in cutaneous neuroimmunology have substantially expanded our understanding of inflammatory skin diseases, revealing an intricate bidirectional network linking peripheral sensory neurons, resident immune cells, and structural skin components. Among the mediators or...

The Acceptance of Relationship Red Flags and Romantic Myths in Adolescents’ Judgments of Teen Dating Violence: A Cross-Sectional Vignette Study

Teen dating violence (TDV) is a prevalent phenomenon, yet the role of cognitive–attitudinal factors such as the acceptance of relational “red flags” and the endorsement of romantic myths remains insufficiently explored. This study investigates how these factors are associated wit...

The Osteosarcoma Tumor Microenvironment: From Cellular Interactions to Advanced Preclinical Models

OS is the most common primary malignant bone tumor, predominantly affecting children, adolescents, and young adults. Despite advances in multimodal treatment, patient outcomes have remained largely unchanged over the past decades, particularly in cases of metastatic or recurrent...

Nutrition, Sedentary Behaviour and Physical Activity in Undergraduate Students: A Scoping Review with PRISMA-ScR Checklist

Background/Objectives: University students are particularly vulnerable to unhealthy lifestyle behaviours, including poor dietary habits, insufficient physical activity, and prolonged sedentary time. While these three behaviours have each been extensively studied individually, the...

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but a reproducible mechanistic account of individual variation in incentive salience attribution has been lacking. Using fMRI across five cohorts (N-total=1,251; N1=890; N2=245; N3=34; N4=48; N5=3...

Difficult-to-treat systemic lupus erythematosus: from refractory disease to a multidimensional clinical trajectory

Difficult-to-treat (D2T) systemic lupus erythematosus (SLE) is increasingly recognised in clinical practice but is still conceptually underdeveloped. In contrast to rheumatoid arthritis and psoriatic arthritis, for which formal D2T frameworks have been proposed, SLE still lacks a...

Identification and characterization of TrxA: a novel bacterial thioredoxin–metallothionein chimera

Abstract Heavy metals (HMs) are naturally occurring elements which can be essential, such as zinc, copper, and iron, or non-essential, including cadmium, mercury, and lead. While essential metals serve as cofactors in critical enzymatic processes, elevated concentrations of both...

Different effects of fear and happiness on visual organization

Abstract How emotional factors influence visual organization remains incompletely understood, particularly beyond early sensory processing. Across three experiments, we investigated whether emotional facial expressions modulate perceptual grouping and whether individual affective...

Amino-Functionalized DWCNTs Tailor Curing Kinetics and Multifunctional Performance of Epoxy Nanocomposites

The influence of amino-functionalized double-walled carbon nanotubes (DWCNTNH2) on the curing behavior and multifunctional properties of an epoxy resin was systematically investigated. Isothermal FTIR analysis, interpreted using Kamal’s autocatalytic model and model-free isoconve...

PIK3CA in Cancer: Structure, Biology, Alterations, and Actionability

PIK3CA, which encodes the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K), is one of the most frequently altered oncogenes in human cancer and a major driver of tumor initiation, progression, metastasis, and therapeutic resistance. Over the past two decades, advances...

Adjunctive nutraceutical strategies in ulcerative colitis: From molecular pathways to clinical outcomes

Ulcerative colitis is a chronic inflammatory disease of the large intestine, involving flare-ups and remissions. Its exact causes are unclear, but genetic susceptibility, immune dysregulation and environmental influences promote development. Conventional treatments have improved...

Diabetic Cardiomyopathy: Distinct Clinical Entity or Manifestation of Metabolic Heart Disease?

Background/Objectives: Type 2 diabetes mellitus (T2DM) is a global epidemic strongly associated with an increased risk of heart failure, independent of coronary artery disease or hypertension. This condition, historically termed diabetic cardiomyopathy (DCM) and recently redefine...

Robot-Assisted Versus Open and Laparoscopic Radical Nephrectomy with Inferior Vena Cava Thrombectomy forRenal Cell Carcinoma: A Systematic Review and Meta-Analysis

Background/Objectives: To compare perioperative, pathological, functional, and oncological outcomes of robot-assisted radical nephrectomy with inferior vena cava tumor thrombectomy (RARN-TT) versus open (ORN-TT) and laparoscopic (LRN-TT) approaches. Methods: PubMed, Scopus, and W...

A Modified Delphi consensus on early management of combined cardiovascular risk factors in adult patients with type 2 diabetes in Italy

BACKGROUND: Type 2 diabetes (T2D) is a complex chronic disease often associated with other metabolic conditions that increase the risk of cardiovascular (CV) disease and early mortality. Hence, early, integrated management of T2D may prevent long-term CV complications. METHODS: T...

Persistent Unexplained Hydronephrosis in an Adolescent: A Multimodal Imaging Challenge

ABSTRACT Renal vein aneurysm (RVA) is an exceptionally rare vascular anomaly and an unusual cause of hydronephrosis. We report an asymptomatic 17‐year‐old male with persistent right hydronephrosis and preserved renal function. Serial ultrasonography demonstrated progressive pelvi...