University of Aberdeen

Modeling maternal immune activation in 3D ex vivo human fetal brain cerebroids reveals IL-17A-driven disruption of cortical development

Abstract Maternal immune activation (MIA) disrupts brain development and increases the risk of neurodevelopmental disorders, yet the mechanisms by which MIA impacts human cortical development remain poorly understood. Here we introduce a three-dimensional ex vivo culture system,...

The influence of negative affective states on the neurophysiological correlates of prospective memory

Abstract Prospective memory (PM), the ability to remember to perform an intended action in the future, is influenced by affective states. We tested two opposing theoretical accounts regarding the effects of negative affect on cognitive tasks using behavioral and neural data to be...

Ly6d expression delineates two putative postnatal thymus epithelial progenitor cells that are differentially affected by aging

To date, the identity and maintenance of postnatal thymic epithelial progenitor cells (TEPCs) remain unclear, as does the persistence of bipotent TEPCs after birth or whether lineage-restricted progenitors independently maintain separate TEC compartments. Using an inducible linea...

Solving problems increases provisioning efficiency, enhancing reproductive success in male great tits

Abstract The ecological and selective processes acting on cognitive traits have received recent attention because of the potentially key role of cognition in rapid behavioural adjustments in response to environmental variation. Innovation, a cognitive process involved in the deve...

What can comprehensive mapping of alternative food networks reveal about their sustainability claims?

Alternative Food Networks (AFNs) are widely understood as responses to the sustainability crises of the conventional food systems. AFNs in Scotland also build upon long-standing local food traditions that predate these crises, yet little attention has been given to understanding...

Clinical efficacy to climate accountability

There is increasing global recognition of the importance of sustainability in the design and delivery of healthcare, including trauma and orthopaedics. There has, however, to date been little focus on providing high-quality research which includes environmental outcomes to guide...