University Medical Center of the Johannes Gutenberg University Mainz

Two-year efficacy and safety outcomes of the Paul Glaucoma Implant compared to the Ahmed Glaucoma Valve

PURPOSE: To compare efficacy and safety profiles of the Paul Glaucoma Implant (PGI) and Ahmed Glaucoma Valve (AGV) in the treatment of adults with glaucoma over a 2-year of follow-up period. METHODS: This retrospective, single-center, comparative study included adult patients who...

The Plasmodium heme detoxification protein functions in mitochondrial protein synthesis

Abstract Malaria blood-stage parasites digest ~80% of host cell hemoglobin within a degradative vacuole, releasing heme that is detoxified by sequestration into hemozoin crystals. Although essential for survival and a validated drug target, the mechanisms of heme biomineralizatio...

Calr-mediated calcium buffering: a molecular barrier to in vivo cardiac reprogramming

In a recent publication in Cell Stem Cell , Cai et al. 1 employed an in vivo Perturb-seq strategy to systematically identify molecular barriers that limit direct cardiac reprogramming following myocardial infarction (MI). This study provides a conceptual and technological framewo...

Effective Reductionof Anti-PEG Antibody Recognitionvia PEG Copolymers with Ethyl Glycidyl Ether and Isopropyl GlycidylEther

Abstract Anti-PEG antibodies (APAs) lead to accelerated blood clearance of PEGylated drugs and nanocarriers. Randomized PEG (rPEG) reduces APA recognition by randomly incorporating glycidyl methyl ether in PEG. Extending this concept, statistical copolymerization of ethylene oxid...