University Medical Center of the Johannes Gutenberg University Mainz

Lifestyle factors associated with biofunctional age in a cross-sectional study of adults aged 35 and older

Abstract Ageing is a complex process influenced by chronological age, gender, genetics, lifestyle and environment leading to intra- and inter-individual variability in vitality and the trajectory of healthy ageing. This study aimed to identify key lifestyle factors and to develop...

Decoding radiation-induced transcriptomic signatures of human leukocytes using long-read RNA-seq: clinical and biodosimetric implications

Abstract Background Gene expression profiling in radiation-exposed blood is a valuable tool for biodosimetry and clinical research. Evaluating the blood’s transcriptomic radiation response provides insight into absorbed dose, hematotoxicities, and immune reactions. However, detai...

Trends in glaucoma diagnosis and medical management in Germany: A nationwide claims data analysis over 10 years

Abstract Purpose Analysing longitudinal trends in recorded diagnosis and medical management of glaucoma in Germany over a 10‐year period. Methods A retrospective cohort study using nationwide outpatient claims and prescription data from the German statutory health insurance syste...

Elevated prenatal IL-6 levels disrupt early patterns of hippocampal electrical activity and chloride homeostasis by targeting GABAergic signaling at perinatal stage

Abstract Early patterns of neuronal electrical activity are fundamental for driving critical developmental processes, including neuronal maturation and synapse formation. While genetic programs are key in orchestrating these events, the influence of environmental stressors remain...

Distal Radial Access for Thoracic Branch Endoprosthesis Deployment: Two Cases of Successful TEVAR with Left Subclavian Artery Revascularization

Background and Clinical Significance: Thoracic endovascular aortic repair (TEVAR) involving zone 2 of the aortic arch frequently necessitates left subclavian artery (LSA) revascularization to reduce the risk of neurologic and ischemic complications. If endovascular methods are em...

Gold Nanoparticle Shape and Protein Corona Effects on Radiosensitization in Neuroblastoma Cells

Abstract Gold nanoparticle (GNP) radiosensitization is influenced by particle shape and the protein corona acquired in biological environments. We investigated how GNP shape and a preformed human plasma protein corona affect the radiation response of SH-SY5Y neuroblastoma cells e...

Disease Duration Differentiates Freezing of Gait Response to Subthalamic and Nigral Stimulation for Parkinson's Disease in an Exploratory Multicenter Controlled Trial

BACKGROUND: Freezing of gait (FoG) belongs to most pressing unmet symptoms in the treatment of Parkinson's disease. OBJECTIVES: To explore whether combined subthalamic and nigral (STN + SNr) deep brain stimulation improves FoG compared with optimized STN stimulation alone; to ide...

Hypoxia and right ventricular dysfunction in patients with acute pulmonary embolism

In patients with acute pulmonary embolism (PE), hypoxia may increase pulmonary vascular resistance and worsen right ventricular dysfunction (RVD), which is a key prognostic factor. However, associations between hypoxia, RVD and clinical outcomes have not been well described. To d...

Exploring Family Interactions: Heterogeneity in Family Specific Network Models

ABSTRACT Daily family interactions have a profound impact on children's emotional and behavioral development. While extensive research highlights the detrimental effects of negative parenting practices and the benefits of positive parenting programs, less is known about the compl...

Short Dental Implants as Strategic Support for Removable Partial Dentures in Mandibular Free‐End Situations: A 3‐Year Prospective Cohort Study

ABSTRACT Objectives This study aimed to assess the mid‐term clinical performance of short implants as strategic support for mandibular removable partial dentures (RPDs) with free‐end situations. Methods Subjects wearing lower RPDs in Kennedy Class I situations received two suppor...

Clindamycin under pressure: resistance in hospitalized patients with odontogenic infections and a penicillin allergy label – a multicenter retrospective study

Odontogenic infections may progress to deep space infection with systemic complications and require prompt surgical drainage and, when indicated, systemic antibiotics. In patients with a documented penicillin allergy label, empiric therapy is often shifted toward clindamycin, alt...

Critical windows: timing of child maltreatment exposure and adult mental health

Abstract Background Despite being recognized as the leading risk factor for mental disorders, child maltreatment (CM) remains insufficiently understood regarding type and timing of exposure. This study examines which developmental periods of exposure to CM subtypes are most stron...

Recurrence patterns and survival outcomes in advanced papillary thyroid carcinoma: a retrospective cohort analysis

Abstract Papillary thyroid carcinoma (PTC) is the most common malignant thyroid tumor, with a small proportion of patients presenting with advanced disease. The recent European Society of Endocrine Surgeons (ESES) consensus introduced a refined definition of advanced thyroid canc...

Interdependence of dental parameters, mandibular mobility and static postural sway as well as load distribution in male subjects of advanced working age

Abstract Background Maintaining static postural sway as well as load distribution is an essential component of overall physical stability in older age. The temporomandibular system is a measurable influencing factor due to functional interdependencies, although it has not yet bee...

PfATG18 links V-ATPase assembly to endocytic membrane dynamics in malaria parasites

Malaria parasites replicate inside red blood cells, degrading hemoglobin within a specialized digestive vacuole. Efficient hemoglobin processing is essential for parasite survival and influences antimalarial drug susceptibility. The vacuole constantly fuses with incoming hemoglob...

Improving patient communication and understanding of medical reports through text simplification with ChatGPT: a comparative study

PURPOSE: Medical documentation is essential for clinical communication but is often intended for professional audiences, limiting patient understanding. This linguistic complexity can reduce health literacy and hinder shared decision-making. Large language models offer new opport...

Lysed erythrocyte membranes metabolically prime endothelial cells for angiogenesis

Endothelial dysfunction is a hallmark of pathological angiogenesis and associated with erythrocyte extravasation and lysis. Whether mediators released from lysed erythrocytes instruct endothelial cells (ECs) for new vessel formation is unknown. Here, we show that the membrane fra...

A Statistical Perspective on Transformers for Small Longitudinal Cohort Data

ABSTRACT Modeling of longitudinal cohort data typically involves complex temporal dependencies between multiple variables. There, the transformer architecture, which has been highly successful in language and vision applications, allows us to account for the fact that the most re...

Deep Learning-Based Image Reconstruction in Ultra-High-Resolution CT Venography for Improved Visualization of Cerebral Venous Drainage

Abstract Purpose To evaluate the diagnostic confidence and image quality of deep-learning-enhanced ultra-high-resolution CT venography (CTV) in venous neurovascular imaging, compared with hybrid iterative reconstruction of ultra-high-resolution CT datasets and normal-resolution C...

War-related and psychological predictors of experiential and physiological fear of war in Germany: findings from a nationally representative survey

Abstract Background Fear of war has emerged as a relevant psychosocial phenomenon in Europe, yet little is known about factors associated with its experiential and physiological dimensions in representative populations. This study examined sociodemographic, war-related, and psych...