University Medical Center Hamburg-Eppendorf

Shared molecular pathways in pediatric genetic epilepsies: Insights from a single‐center cohort of 80 patients

Abstract Objective Genetic epilepsies in childhood are highly heterogeneous, and approaches to identify shared biological mechanisms across distinct genetic etiologies remain limited. We aimed to investigate whether genes associated with pediatric genetic epilepsies in our hetero...

International Modified Delphi Consensus on Assessment and Management of Covert Brain Infarction

BackgroundCovert brain infarction (CBI) is a frequent incidental neuroradiological finding increasingly recognized as clinically relevant due to its association with stroke, cognitive decline, and other adverse outcomes. However, substantial uncertainty remains regarding its opti...

Parameter Estimation for Model-Based Sensing of Magneto-Mechanical Resonators

Abstract Magneto-mechanical resonators (MMRs) represent a recently proposed type of passive sensor that enables the estimation of its pose as well as sensing other parameters in its environment. The working principle of MMRs entails an excitation of the sensors by oscillating mag...

Efficient Chebyshev reconstruction for the anisotropic equilibrium model in magnetic particle imaging

Abstract Objective: Magnetic Particle Imaging (MPI) is a tomographic imaging modality capable of real-time, high-sensitivity mapping of superparamagnetic iron oxide nanoparticles. Model-based image reconstruction provides an alternative to conventional methods that rely on a meas...

Relieving the Burden on Caregivers: A Single-Group, 4-Week Pilot Study Evaluating the Impact of a Brief Online Psychoeducation Program (AES) on Burden Reduction and Schizophrenia-Related Knowledge for Informal Caregivers of Individuals with Schizophrenia in German-Speaking Countries

PURPOSE: Informal caregivers of people with schizophrenia often face substantial psychological burden and limited support. Although psychoeducational family interventions are effective and are recommended by international guidelines, their clinical use is limited by systemic and...

Tinnitus in urban settings: insights into lifestyle and medical factors from the Hamburg City Health Study

PURPOSE: Tinnitus is a common and multifactorial auditory condition associated with considerable psychosocial burden. Evidence regarding its relationship with demographic, lifestyle, and medical factors remains inconsistent. This study aimed to determine the prevalence and correl...

Total en Bloc Urethra Preservation at Robot-Assisted Prostatectomy (ToP-RAP): A Prospective IDEAL Stage 1–2a Study

Background/objective: Urinary continence recovery after robot-assisted radical prostatectomy remains variable despite technical refinements intended to preserve function. We describe Total en bloc Urethra Preservation at Robot-assisted Prostatectomy (ToP-RAP), a technique that pr...

3D Nanoprinted Structures Promote Robust Integration of Brain Organoids into Topography‐Guided Neuronal Networks

ABSTRACT Two‐photon polymerization‐based 3D nanoprinting (3DN) is a potent tool for the fabrication of highly specialized cultivation platforms that enable guided neuronal networks. However, despite the design freedom offered by 3DN, specialized cultivation platforms that activel...

Rheumatologists’ expectations and perceptions of T-cell redirecting therapies: results from a cross-sectional survey

Abstract T-cell redirecting therapies (TCRTs), including Chimeric antigen receptor (CAR)-T cells and T-cell engagers (TCEs), are emerging as transformative treatments for autoimmune diseases. However, clinical application is currently restricted to specialized centers, leaving mo...

A comparative study of causal machine learning models for personalized treatment of acute ischemic stroke

Abstract Background Accurate estimation of the individualized treatment effect (ITE) is critical for supporting personalized decision-making in acute ischaemic stroke, while the average treatment effect (ATE) provides a cohort-level benchmark for method comparison and context. Ho...

Insights into the survival impact of delayed immunochemotherapy in newly diagnosed diffuse large B-cell lymphoma: results from a nationwide registry study

BACKGROUND: The prognostic impact of the diagnosis-to-treatment interval (DTI) in diffuse large B-cell lymphoma (DLBCL) remains controversial. We investigated the association between DTI and three-year all-cause mortality in a nationwide cohort. METHODS: We conducted a retrospect...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Pain characteristics in isolated cervical dystonia: comparison to orthopedic cervical conditions and assessment of botulinum toxin effects

Abstract The objective was to characterize pain and evaluate quality of life (QoL) in cervical dystonia (CD) by comparing pain profiles with patients affected by orthopedic cervical conditions (OCC) and evaluating differences between CD patients with and without head tremor (HT)....

Prophylactic vs Therapeutic Anticoagulation in Hospitalized Patients With COVID-19

Importance Coagulopathy in the context of COVID-19 is a major threat due to deep vein thromboses and pulmonary embolisms. Objective To assess whether therapeutic anticoagulation on top of standard of care (SOC) compared with prophylactic anticoagulation as part of SOC can improve...

Diagnostic concordance of remote WSI-based thyroid cytology compared to conventional cytological diagnosis: a pilot study

Abstract Background Whole slide imaging (WSI) has emerged as a key component of digital pathology, enabling remote diagnostics and standardized evaluation. However, its diagnostic concordance in thyroid cytopathology, particularly under real-world conditions, remains insufficient...

Family-centred psycho-oncological counselling for parents with cancer: a longitudinal secondary data analysis of psychological distress, family functioning and parental concerns

BACKGROUND: When a parent is diagnosed with cancer, it can place a significant burden on the entire family. The aim of this study is therefore to analyse the psychological distress experienced over time among cancer patients or their partners who are raising minor children and wh...

A multi-site loiasis dataset of whole blood videos

Loiasis is a blood-borne filarial infection under consideration for inclusion in the WHO’s priority list of Neglected Tropical Diseases. In addition to its direct impact on human health, loiasis frequently occurs as a co-infection with other filarial diseases, including onchocerc...

Summary of Research: HER2CLIMB-05: A Phase III Study of Tucatinib Versus Placebo in Combination with Trastuzumab and Pertuzumab as First-Line Maintenance Therapy for HER2+ Metastatic Breast Cancer

This is a summary of a research article reporting the findings of the HER2CLIMB-05 trial (NCT05132582), a randomized, double-blind, placebo-controlled, international, phase III trial. The HER2CLIMB-05 trial was conducted to compare the efficacy and safety of adding tucatinib vers...

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF ‐Tu for AMPylation

Fic enzymes mediate diverse post-translational modifications, including adenosine monophosphate (AMP) transfer and removal, referred to as AMPylation and deAMPylation, respectively. We identified the prokaryotic translation elongation factor Tu (EF-Tu) as an AMPylation target of...

Neural responses during natural vision are action-timed rather than locked to the onset of stable foveal input

Visual processing is traditionally studied using static viewing paradigms in which researchers analyse brain responses to the onsets of a sequence of randomly selected stimuli. Translating this “stimulus onset” approach to active vision paradigms that allow for free eye-movements...