University Hospitals of Leicester NHS Trust

A scoping review of digital health technologies in glycogen storage diseases

Abstract Glycogen storage diseases (GSDs) are rare inherited metabolic disorders requiring complex management. Digital health technologies (DHTs) offer solutions for improving care delivery, yet their implementation remains poorly characterised. This scoping review systematically...

Improving patient-reported outcome measure scoring in shoulder trials

Aims Patient-reported outcome measures (PROMs) underpin orthopaedic trials by capturing pain and function from the patient’s perspective. Traditionally, PROMs such as the Oxford Shoulder Score (OSS) are scored using classical test theory (CTT), which assumes equal item contributi...

Population‐Stratified Distributions of Post‐Mortem Blood Drug Concentrations: An Epidemiological Framework for Contextual Interpretation

ABSTRACT Interpretation of post‐mortem drug concentrations remains a major challenge in forensic toxicology because factors, including post‐mortem redistribution, drug tolerance, polypharmacy and inter‐individual variability, limit the utility of fixed therapeutic, toxic or purpo...

Management of Type 2 Diabetes, 2026. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

The American Diabetes Association and the European Association for the Study of Diabetes convened a panel to update the consensus statement on the management of type 2 diabetes in nonpregnant adults, published since 2006 and last updated in 2022. The target audience is the multid...

Transient Neonatal Uterine Bleeding Offers a Window to Understanding Uterine Development

The phenomenon of neonatal uterine bleeding was observed over centuries. It was dismissed as having no clinical relevance. Alternatively, it was hypothesized to be associated with early-onset endometriosis, but its exact clinical significance remains unknown. We conducted a narra...

Addressing evidence gaps in haemodialysis care: a critical review of clinical trials, technological innovations, and implementation priorities

Kidney failure treated with maintenance haemodialysis (HD) carries high risks of premature mortality, hospitalisation and impaired quality of life, yet important evidence gaps persist across routine HD care. The Dialysis Research Innovation Network, part of the UK Kidney Research...

Interactions Between Health Inequalities on the Management and Outcomes of Thoracic Aortic Disease in England: A National Cohort Study

BACKGROUND: The aim of this study was to evaluate the intersectionality between measured causes of health inequality and clinical factors that influence treatment decisions and regional variations in care and survival for people with thoracic aortic disease (TAD) in England. METH...

Synergistic Effect of Ambient Ozone, Relative Humidity, and Temperature on Epidemic Patterns of Influenza: A Hypothesis and Its Verification

The mechanisms underlying seasonal patterns in influenza epidemics have long been an enigma. Our laboratory study revealed that ambient ozone significantly inactivates airborne influenza viruses synergistically with higher relative humidity and temperature. This led us to hypothe...

Prevalence of Stress, Anxiety, and Depression Among Pregnant Women in Riyadh, Saudi Arabia

Background & Objective: Pregnancy is a vulnerable period for psychological distress, yet Riyadh-specific data describing stress, anxiety, and depression simultaneously and their correlates remain limited. This study was conducted with aim to estimate the prevalence of antenatal s...

Media representations of postpartum depression in UK newspapers (2020–2025): A thematic content analysis

Abstract Purpose Postpartum depression (PPD) is a common maternal mental health disorder, affecting up to one in six mothers, with serious consequences for maternal well-being, child development, and economic costs. Media shape public mental health perceptions, and newspapers rem...

Can you FORCE research implementation? A PERUKI survey to evaluate knowledge translation of the FORCE study

Aims: To assess the uptake of the Forearm Fracture Recovery in Children Evaluation (FORCE) trial findings into clinical practice, and to identify the influence of targeted dissemination tools on implementation. Methods: A cross-sectional electronic survey was distributed via the...

Quality and concordance of international paediatric sepsis guidelines: a cross-sectional appraisal from the SENTINEL International study

Objectives To evaluate the methodological quality of hospital-specific paediatric sepsis clinical practice guidelines (CPGs) from sites participating in an international study using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool and to assess the consi...

Association of Reallocation of Movement Behaviours with Ectopic Fat Accumulation: A Cross-Sectional Analysis of the UK Biobank Cohort

Purpose: Ectopic fat in non-adipose tissues is linked to higher chronic-disease risk. Using the UK Biobank, this study examined associations of device-measured physical activity (PA) and sedentary time with ectopic fat. Methods: Liver and pancreas proton density fat fraction (PDF...

Hypertrophic cardiomyopathy: a genome-wide association meta-analysis and polygenic risk score

ABSTRACT Background Hypertrophic cardiomyopathy (HCM) is a heritable trait with marked variability in expression and outcomes. Our aims were to discover new genetic loci associated with HCM and to test the effect of a new polygenic risk score (PRS) on incidence, phenotype and out...

Exploration of the relevancy of nutritional knowledge and self‐perceived nutrition competency of the UK Optometric Workforce

Abstract Purpose This study investigated the self‐perceived competence, knowledge, confidence and attitudes of the UK optometric workforce with regard to nutritional advice for patients. Methods A validated questionnaire (NUTrition COMPetence) was used to survey the optometric wo...

Sedentary behaviour change: barriers and strategies reported by individuals with type 2 diabetes during a multi-component intervention

Abstract Introduction Engaging in high volumes of sedentary behaviour increases the risk of adverse health outcomes, especially for individuals with Type 2 diabetes mellitus (T2DM). Understanding likely influences on behaviour and effective strategies for reducing sedentary time,...

Antimicrobial effectiveness within a new paradigm of infrastructure

Antimicrobials form the backbone of modern medicine and represent a foundational pillar of economic productivity. Overuse and misuse have led to a rising trend of antimicrobial resistance (AMR), depleting the efficacy of existing antimicrobials, necessitating conservation through...

International healthcare professionals’ competence in caring for LGBTQ+ children and young people: a combined qualitative and quantitative approach

Objective To evaluate healthcare professionals’ attitudes, knowledge and clinical preparedness in caring for lesbian, gay, bisexual, transgender, queer/questioning; the + denoting inclusion of all identities (LGBTQ+) children and young people across international healthcare setti...

Smartphone addiction screening status and associated physical and neuropsychological symptoms among Syrian university students: a cross-sectional study

Smartphone addiction (SPA) has emerged as a growing public health concern, especially among university students, due to long usage times and the possibility of being affected both physically and neuropsychologically. With little research on these connections in the literature, th...

Protein-Containing Breakfasts Are Associated with Reduced Postprandial Glycaemic Excursions in Children and Young People with Type 1 Diabetes: A Pragmatic Study

Background/Objectives: This study examined whether adding 10 g of protein to a high glycaemic index (GI) breakfast could attenuate postprandial glycaemic responses in children and young people (CYP) with type 1 diabetes (T1D). Postprandial glucose responses following this modifie...