University Hospital Zurich

Chorda Tendinea Obstruction of Impella Causing Massive Hemolysis Detected by Methemoglobinemia: A Case Report

The Impella microaxial flow pump is increasingly used in cardiogenic shock and high-risk coronary interventions. Hemolysis is a frequent complication, but established markers lack bedside availability. We report the first case of Impella obstruction by a chorda tendinea, causing...

Hospital-Level Determinants of Mortality After Pancreas Surgery

OBJECTIVE: To identify modifiable hospital-level determinants of mortality after pancreas surgery and assess their cumulative protective effects through the development of a Hospital Resource Index (HRI) on a global scale. BACKGROUND: Ninety-day mortality rates after pancreas sur...

Rehabilitation and the post-intensive care syndrome across the recovery continuum: a narrative review

Purpose Improved survival from critical illness has produced a growing population of intensive care unit (ICU) survivors with new or worsened physical, cognitive, and mental-health impairment, defined as post-intensive care syndrome (PICS), and frequent distress among families/ca...

A distinct gastrointestinal symptom profile characterizes clinically relevant fatigue in systemic sclerosis

OBJECTIVE: To identify the specific gastrointestinal (GI) symptoms associated with clinically relevant fatigue in systemic sclerosis (SSc), beyond the established association between overall GI involvement and fatigue. METHODS: We conducted a cross-sectional study including conse...

Impact of Osteoporosis Therapy in Geriatric Proximal Femur Fractures: A Retrospective Analysis from the German Registry for Geriatric Trauma (ATR-DGU®)

Background: Each year, hundreds of thousands of geriatric patients suffer proximal femur fractures, which often result in irreversible functional decline. Although anti-osteoporotic medications have been shown to reduce the incidence of fragility fractures, the effects of pharmac...

Improving survival in Duchenne muscular dystrophy across eras: a systematic review and cumulative meta-analysis

BACKGROUND: Duchenne muscular dystrophy (DMD) was historically associated with death in the late teens or early twenties, mainly from respiratory failure. Survival has improved substantially with home mechanical ventilation (HMV) and multidisciplinary care, although variability r...

Understanding implementation patterns of the FICUS family support intervention: a matrixed multiple case study across Swiss adult intensive care units

Abstract Background Variations in implementation success across sites are common when introducing complex health interventions; however, such variations are rarely examined systematically, particularly for family-focused interventions in intensive care units (ICUs). As part of a...

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but a reproducible mechanistic account of individual variation in incentive salience attribution has been lacking. Using fMRI across five cohorts (N-total=1,251; N1=890; N2=245; N3=34; N4=48; N5=3...

Identifying optimal dose head CT acquisition techniques through cluster analysis from 904,209 scans

Abstract Objectives To identify clinically established and frequently utilized routine head computed tomography (CT) acquisition techniques in children and adults that achieve lower radiation. Materials and methods The level of the analysis is at the CT scan (series) level. CT ac...

Blue-throated macaws ( Ara glaucogularis ) copy conspecifics in bidirectional control tasks

Abstract Copying via imitation (replicating others’ bodily actions) or emulation (replicating others’ action goals) underpins the cultural transmission of social norms and technical skills in humans. Many non-human animals, ranging from mammals to reptiles, have also been observe...

Guidance for laboratory implementation, governance and continuous assurance of artificial intelligence in histopathology

Abstract Artificial intelligence (AI) is rapidly transforming histopathology, with applications ranging from workflow optimisation and quality assurance to tumour diagnosis, grading, biomarker assessment and estimation of prognosis. While numerous AI algorithms have demonstrated...

Subsite-specific prediction of lymphatic spread in head-and-neck cancer using a mixture of hidden Markov models

Abstract Head-and-neck squamous cell carcinomas (HNSCC) metastasize to neck lymph nodes. Radiation treatments include the elective irradiation of lymph node levels (LNLs) at risk of harboring occult (clinically undetected) metastases. We present a statistical model for personaliz...

Establishment of a novel human nervous system tissue bank: University of Debrecen tissue bank—introduction and retrospective data analysis

Abstract Human brain tissues obtained from autopsies, as well as muscle and nerve samples derived from biopsies, constitute indispensable resources for translational research investigating the pathomechanisms of neuropsychiatric disorders. In this study, we introduce the Nervous...

Autologous hematopoietic stem cell transplantation stabilizes retinal atrophy in multiple sclerosis

Abstract Autologous hematopoietic stem cell transplantation (aHSCT) is an effective treatment for aggressive multiple sclerosis refractory to disease-modifying therapies. Yet, its impact on neurodegeneration remains underexplored, and few predictive biomarkers for clinical outcom...

Subanesthetic nitrous oxide alters large-scale network organization and insula connectivity during visual stimulation

Pharmacological agents that alter consciousness, including classic psychedelics and non-classic agents such as nitrous oxide, are known to affect multiple domains of conscious experience, including visual perception. While most neuroimaging studies rely on resting-state data to c...

Timing of PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation

BackgroundApproximately one half of patients undergoing transcatheter aortic-valve implantation (TAVI) have concomitant coronary artery disease. Although percutaneous coronary intervention (PCI) is often performed before TAVI, the preferred treatment strategy has not been establi...

Improving image quality by reducing breathing artifacts in CT of patients early after coronary artery bypass graft surgery

Abstract The purpose of this study was to evaluate whether a misalignment correction algorithm reduces artifacts from breathing in patients undergoing computed tomography angiography (CTA) early after coronary artery bypass graft (CABG) surgery. In this retrospective study, conse...

Pulmonary Vein Isolation Using Pulsed Field Ablation With vs Without Posterior Wall Isolation in Patients With Symptomatic Persistent Atrial Fibrillation

Importance: Pulmonary vein isolation (PVI) is less effective in persistent than in paroxysmal atrial fibrillation (AF). Objective: To determine whether adding posterior left atrial wall isolation (PWI) to pulsed field ablation (PFA)-based PVI reduces atrial tachyarrhythmia in pat...

Volumetric reference data of the orbit: a deep learning MRI analysis in the German national cohort

Abstract Manual segmentation of orbital magnetic resonance imaging (MRI) is labor-intensive, hindering large-scale morphometric studies. To overcome this, we developed a fully automated deep learning pipeline to segment orbital MRIs and establish age- and sex-stratified normative...

Early definitive fracture fixation (EDFF) does not alter circulatory neutrophil activation status in physiologically restored polytrauma: a 72-h porcine observation study

Abstract Dysregulation of the cellular innate immune system, particularly involving leukocytes and mainly neutrophils, underlies post-traumatic inflammatory complications. Early definitive fracture fixation (EDFF) triggers immune activation and may exacerbate inflammatory complic...