University Hospital Zurich

Automated echocardiographic measurements for longitudinal monitoring of ATTR cardiomyopathy: agreement and repeatability analysis

Detection of disease progression is key to personalize treatment strategies in transthyretin cardiomyopathy (ATTR-CM), particularly with emerging therapies. Echocardiography can detect subtle longitudinal changes but is limited by operator dependence. This study evaluates agreeme...

Electroretinographic assessment of retinal function in preterm infants using the RETeval™ device: a proposal for reference data

Abstract Purpose To establish age-adjusted flicker ERG reference values in premature infants through serial recordings, aiming to characterize retinal functional maturation and support diagnostic interpretation in retinopathy of prematurity screening. Methods This prospective lon...

Fluid-intolerance signals as bedside safety limits during early septic shock resuscitation: a multicenter randomized trial

Fluid resuscitation in early septic shock has a narrow therapeutic index. Signals of fluid intolerance are frequently present during early resuscitation, yet current resuscitation strategies do not incorporate them to guide when to limit fluid administration. We evaluated whether...

Stimulatrix: An open-source automated platform for high-throughput functional characterization of engineered contractile tissues

Engineered cardiac and skeletal muscle tissues suspended between flexible posts support disease modeling and pharmacology, yet their stimulation, longitudinal imaging and quantitative analysis often remain fragmented and labor-intensive. Here we present Stimulatrix, an open-sourc...

Neuropsychological follow-up and audiometry in Susac syndrome — a case report

Abstract Susac syndrome is an extremely rare autoimmune disease which is characterized by encephalopathy, cochleo-vestibular damage resulting in sensorineural hearing loss, and branch retinal artery occlusion (BRAO) leading to visual disturbances. The number of reported cases wor...

Albendazole Treatment of Alveolar Echinococcosis in a Trial Based on a Cross Sectional Ultrasound Study in Kyrgyzstan

ABSTRACT Background Human alveolar echinococcosis (AE) is a potentially fatal parasitic disease. In the low‐resource country of Kyrgyzstan, it is essential to develop protocols to manage the large number of AE cases being diagnosed. Methods A randomised trial was undertaken to ex...

How I do it: microsurgical extraforaminal sequestrectomy through a midline intertransverse approach

Abstract Background Several surgical approaches exist for extraforaminal (far lateral) lumbar disc herniations, including paraspinal Wiltse-type, interlaminar, lateral intertransverse, and combined medial–lateral techniques. Method We present microsurgical extraforaminal sequestr...

Sport, exercise, and physical activity in children with cardiovascular disease. A Clinical Consensus Statement of the European Association of Preventive Cardiology (EAPC) of the ESC, the Association of Cardiovascular Nursing & Allied Professions (ACNAP) of the ESC, and the Association for European Paediatric and Congenital Cardiology (AEPC)

Regular physical activity offers numerous benefits to children's health and well-being and is essential for reducing cardiovascular risk in children with cardiovascular disease. Despite increasing evidence supporting its benefits, many young patients remain insufficiently active...

Chronic Kidney Disease‐Associated Pruritus Is Linked to Selective Enrichment of Taurine‐Conjugated Bile Acid Subspecies

ABSTRACT Background Chronic kidney disease‐associated pruritus (CKDaP) is a common and debilitating symptom in patients with advanced renal disease. The underlying pathophysiology of CKDaP remains poorly understood, but dysregulation of bile acid metabolism has been suggested as...

Real-World Experience With the Extravascular Implantable Cardioverter Defibrillator Through 1 Year: The Enlighten Post Approval Registry Study

BACKGROUND: The extravascular implantable cardioverter defibrillator (EV-ICD) was developed to provide defibrillation and antitachycardia pacing therapy without the need for intravascular lead placement. Premarket clinical trials reported EV-ICD safety and efficacy through 3 year...

The liver niche accelerates, while the lung niche restrains secondary spread of breast cancer

Breast cancer progression to visceral organs such as the lung and liver is associated with poor prognosis. Yet, these organs have diverse cellular microenvironments that may differentially influence cancer cell behavior. Here, we show that breast cancer metastases differ in their...

Oncogene-driven genomic profiles are linked to poor overall survival in muscle-invasive bladder cancer (MIBC)

Abstract Purpose Muscle-invasive bladder cancer (MIBC) is a genomically complex disease with limited biomarkers for predicting patient outcomes. This study aimed to identify molecular correlates of overall survival in MIBC through comprehensive genomic profiling. Methods Tumor DN...

Severe antipsychotic-associated gastrointestinal hypomotility: AMSP pharmacovigilance data from 333,175 psychiatric inpatients

Abstract Background Severe courses of gastrointestinal hypomotility (GIH) are rare but potentially life-threatening adverse drug reactions (ADRs) associated with antipsychotic drugs (APDs). This study aimed to investigate the frequency, clinical characteristics, and associated dr...

Safety and Efficacy of Right‐ Versus Left‐Sided Transvenous Lead Extraction

ABSTRACT Background and Aims Transvenous lead extraction (TLE) is increasingly performed for malfunction or infection of cardiac implantable electronic devices. Because of anatomic differences, TLE for right‐sided (RS) electrodes may differ in outcome. This study aimed to evaluat...

An automated high-resolution screening platform identifies regulators of anchor cell invasion in C. elegans

Microfluidic devices are valuable tools for live imaging. However, widespread adoption of microfluidic-based screening methods has been limited by the complexity of the existing techniques. Here, we introduce a user-friendly, high-throughput, and high-resolution automated imaging...

Quantitative and qualitative lung parameters in photon-counting CT: comparison of ultra-low-dose with standard low-dose protocols

Abstract Objectives Photon-counting CT (PCCT) enables dose reduction beyond energy-integrating CT, but ultra-low-dose acquisitions may impair assessment of airways and lung parenchyma. We evaluated the impact of ultra-low-dose (ULD) PCCT on quantitative and qualitative lung param...

A structural cardiac pathway mediates the risk of ischemic heart disease from TyG-related indices: A prospective cohort study

The triglyceride-glucose (TyG) index and its derivatives are surrogate markers of insulin resistance and are closely associated with cardiovascular risk. However, whether and to what extent they are associated with IHD risk through subclinical cardiac remodeling remains unclear....

Reward reduces motor fatigability by increasing movement vigour

Abstract Reward can enhance motor performance. However, its potential to counteract motor fatigability, a reduction in motor performance during sustained movements, remains underinvestigated. This could be relevant in neurological conditions such as multiple sclerosis, where incr...

Responsible AI for Acute Stroke Management

Artificial intelligence is increasingly integrated into acute stroke management, demonstrating strong performance in tasks such as large vessel occlusion detection, Alberta Stroke Program Early Computed Tomography Score scoring, and functional outcome prediction. However, concern...

Advancing minimally invasive precision surgery in large open cavities with robotic flexible endoscopy

Flexible robots hold great promise for enhancing minimally invasive surgery (MIS) by providing superior dexterity, precise control, and safe tissue interaction. Yet, translating these advantages into endoscopic interventions in large open cavities remains challenging. The lack of...