University Hospital of Basel

FOXC1 and its lncRNA FOXCUT link DNA methylation to a chondrocyte phenotype dysfunction

Abstract Objective With current osteoarthritis (OA) therapies limited to symptom management, understanding molecular drivers of disease progression is critical. As epigenetic mechanisms increasingly appear central to OA pathogenesis, this study aimed to identify epigenetically dy...

Dimensional accuracy and flexural strength of 3D-printed photopolymer resins for point-of-care surgical guides after steam and plasma sterilization: an in-vitro comparative study

Abstract Background Three-dimensional (3D) printing enables the fabrication of patient-specific guides (PSGs) for oral and craniomaxillofacial procedures. Before clinical use, guides must be sterilized, which may compromise dimensional accuracy and mechanical performance. The eff...

Left atrial anatomy and atrial arrhythmia recurrence after pulsed-field ablation

Abstract Background The impact of left atrial (LA) anatomical features on atrial arrhythmia (AA) recurrence after pulsed-field (PF)-based pulmonary vein isolation (PVI) is unknown. This study aimed to assess LA anatomical features associated with long-term AA recurrence after PVI...

Utilization of Carbon Fiber Spinal Instrumentation in Primary Spinal Tumors: Outcome Analysis from the AO Spine Primary Tumor Research and Outcomes Network

Background The use of carbon fiber-reinforced polyetheretherketone (CFR-PEEK) instrumentation in spinal surgery has emerged as an alternative to traditional titanium-based implants in recent years. This study aims to evaluate the use and performance of carbon fiber instrumentatio...

Annual Research Review: Sex differences in conduct disorder – revisiting existing evidence and exploring future directions

Conduct disorder (CD) is a common psychiatric disorder in youth, characterized by severe and recurrent aggressive and antisocial behaviors and associated with substantial healthcare and societal costs. Rates of CD increase during adolescence in both sexes, with the male‐to‐female...

From established biology to candidate archetypes in high-grade serous ovarian carcinoma: the ARCHETYPE-PX evidence framework and consensus method

Background. High-grade serous ovarian carcinoma (HGSOC) causes most deaths from ovarian cancer, and treatment remains largely empirical outside the homologous-recombination-deficient subgroup. Genomic, immune, stromal and treatment-induced states with different therapeutic vulner...

Placenta–Brain Axis Under Heat Stress: Inflammatory Pathways Linking Prenatal Thermal Exposure to Offspring Neurodevelopment

Climate change is increasing the frequency and intensity of extreme heat events, raising concern about prenatal thermal exposure as a potential risk factor for fetal brain development and offspring neurodevelopment. This systematic review aimed to synthesize evidence on prenatal...

Awareness and management of post-bariatric hypoglycemia: an international survey of healthcare professionals

Abstract Postprandial hypoglycemia (PBH) is a recognized complication following bariatric surgery, but real-world data on its management by healthcare professionals (HCPs) is lacking. To address this, a 25-item multilingual questionnaire was developed and distributed online to HC...

Symptom epidemiology, demographic correlates, and differentiation between cognitive disengagement syndrome symptoms and ADHD symptoms in a large nonprobability sample of Iranian adolescents and adults

Cognitive disengagement syndrome (CDS) is an emerging cognitive-attentional construct characterized by excessive daydreaming, mental slowness, drowsiness, and reduced engagement with external demands. Although CDS symptoms are substantially associated with attention-deficit/hyper...

Bifunctional Phagocytic Synapse Enhancers Remodel the Tumor Microenvironment to Overcome Immunosuppression

Abstract Current immunotherapies often fail in immunologically “cold”, macrophage-rich tumor microenvironments (TMEs). Multi-targeting approaches that modulate innate-adaptive immune activation represent a promising frontier in cancer immunotherapy. Here, we developed phagocytic...

Adverse health outcomes across the life course in individuals with six rare bone diseases: a 10-year population-based cohort study

Abstract Background Rare bone diseases comprise a heterogeneous group of complex and disabling conditions. Evidence on age-specific hospitalization patterns and in-hospital outcomes across multiple rare bone diseases is limited. Methods Population-based cohort study using nationa...

Sex-specific control of locomotor behavior by neuronal Arhgef10 in aged Drosophila

Mutations and polymorphisms in the Rho guanine nucleotide exchange factor 10 (ARHGEF10) locus are associated with behavioral and locomotor dysfunctions in humans, including psychiatric disorders and polyneuropathies that show age- and sex-specific prevalence. ARHGEF10 encodes a c...

Timing of PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation

BackgroundApproximately one half of patients undergoing transcatheter aortic-valve implantation (TAVI) have concomitant coronary artery disease. Although percutaneous coronary intervention (PCI) is often performed before TAVI, the preferred treatment strategy has not been establi...

Pulmonary Vein Isolation Using Pulsed Field Ablation With vs Without Posterior Wall Isolation in Patients With Symptomatic Persistent Atrial Fibrillation

Importance: Pulmonary vein isolation (PVI) is less effective in persistent than in paroxysmal atrial fibrillation (AF). Objective: To determine whether adding posterior left atrial wall isolation (PWI) to pulsed field ablation (PFA)-based PVI reduces atrial tachyarrhythmia in pat...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

Clinical and genetic characteristics of adult patients with familial Mediterranean fever at a German tertiary referral centre

Abstract Objective To characterise the clinical and genetic profile of adult familial Mediterranean fever (FMF) patients at a German tertiary referral centre and examine genotype–phenotype associations. Methods In this prospective single-centre registry study (October 2019–March...

Gut virome instability in HSCT

The gut virome remains one of the least resolved components of the human microbiome, limiting interpretation of how viral communities shape intestinal injury and recovery. Hematopoietic stem cell transplantation (HSCT), particularly in the allogeneic setting, offers an informativ...

How “Micro” Is Microperimetry? Characterizing the Effect of Fundus Tracking on the Psychometric Function

Purpose: The purpose of this study was to quantify whether fundus tracking in microperimetry improves psychometric parameter estimation (as an in vivo demonstration of improved stimulus-delivery precision), and to derive a psychometrically grounded criterion intensity for suprath...

A community-validated tool for clinical outcome calculation in multiple sclerosis: Consensus development and scenario-specific recommendations

Background: Reproducibility and comparability of disability outcomes remain major challenges in multiple sclerosis (MS) research. Definitions of disability progression vary widely across studies, and calculation criteria are often insufficiently documented to enable replication....

Hematogenous vertebral osteomyelitis caused by vaginal microbiota: metagenomic resolution of a polymicrobial anaerobic case

Abstract We describe a rare case of a 35-year-old female patient suffering from polymicrobial hematogenous vertebral osteomyelitis caused by vaginal microbiota following sexual intercourse. Anaerobic blood cultures yielded Fannyhessea vaginae and Gemelliphila asaccharolytica , an...