University Hospital of Basel

International Delphi on a medical screening tool for emergency department patients with psychiatric complaints

Abstract Background: Medical screening in the emergency department (ED) is performed to identify underlying medical conditions that may contribute to a patient’s psychiatric presentation and/or require treatment. This process frequently causes disagreement between emergency physi...

Association of the Red Cell Distribution Width–Albumin Ratio with Myocardial Strain, Mortality, and Heart Failure Hospitalization: A Retrospective Cohort Study

Aims: The aims of this study were to evaluate the association between the red cell distribution width (RDW)–albumin ratio (RAR) and subclinical myocardial impairment, as assessed by left ventricular global longitudinal strain (LVGLS), and to examine the relationships between the...

Protocol for a cluster randomized controlled trial among young people and their peers to reduce substance use and inequitable gender beliefs in Southern Africa

BACKGROUND AND AIMS: Substance use and the internalization of traditional gender norms, or inequitable gender beliefs, are co-occurring risk behaviors for poorer health and well-being in young people in Southern Africa. Addressing the social and structural factors that reinforce...

Chronic alanine aminotransferase elevation in people with HIV : Time trends over 22 years and genetic predisposition

Abstract Introduction Chronic elevation of alanine aminotransferase (cALT) is common in people with HIV. Published reports on cALT prevalence time trends have not been uniform. It is unknown whether genetic background is associated with cALT in people with HIV. Methods cALT was d...

Longitudinal Functional Magnetic Resonance Imaging to Assess Lung Disease in Cystic Fibrosis

Abstract Rationale Matrix pencil decomposition magnetic resonance imaging (MP-MRI) enables quantitative assessment of lung ventilation and perfusion and was shown to correlate with contrast-enhanced (CE) perfusion MRI. Objectives To determine the longitudinal course of MP-MRI par...

Cardiac Myosin‐Binding Protein C for Diagnosis of Myocardial Infarction in Patients With Prior Coronary Artery Bypass Grafting

Background Diagnosing myocardial infarction in patients with prior coronary artery bypass grafting (CABG) remains challenging, primarily because of lower diagnostic accuracy of high‐sensitivity cardiac troponin (hs‐cTn). cMyC (cardiac myosin‐binding protein C), because of its fas...

Th2/Th17 Inflammation: Pathogenic Drivers and Therapeutic Targets in Darier and Hailey‐Hailey Diseases

ABSTRACT Background The inherited acantholytic dermatoses Darier disease (DD) and Hailey‐Hailey disease (HHD) are characterized by a barrier dysfunction of the epidermis susceptible to inflammation and microbial infections. Objectives This study aimed at investigating the express...

Discovery and Optimization of a Novel Brain-Penetrant Colchicine-Binding Site Ligand for Treatment of Glioma

Abstract The limited number of approved drugs for treatment of brain cancers is very apparent. Temozolomide and Vorasidenib continue to be the only approved brain-permeable, orally available drugs. A novel class of highly brain-penetrant tubulin-binding ligands was discovered thr...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Incidence and predictors of delirium-associated violence towards healthcare workers in a Swiss ICU: results from the CAVE study

Abstract Background To assess the frequency of delirium coinciding with aggressive and/or violent patient behavior in intensive care unit (ICU) patients as documented by nurses and to identify clinical associations or risk factors. Methods This was a retrospective observational c...

Perioperative and Periinterventional Platelet Function Testing

Abstract Purpose of the Review This review summarizes the current knowledge on the use of perioperative and periinterventional platelet function monitoring aiming to individualize antiplatelet therapy. Recent Findings In cardiac surgery, the recent guidelines recommend drug-speci...

Feasibility, acceptability, and preliminary estimates of a multimodal AKTIVER Heart Delirium Prevention Program in patients indicated for cardiac surgery: study protocol of a randomized controlled PREVENT POstoperative Delirium (PREVENT-POD) Pilot Study

Abstract Background Postoperative delirium (POD) is a common complication in geriatric patients undergoing cardiac surgery. POD is associated with prolonged length of stay in the intensive care unit and hospital, increased mortality, institutionalization, distress, risk of cognit...

Can Intraoperative Therapeutic Window Data Predict Chronic Contact Selection in Deep Brain Stimulation?

Abstract Deep brain stimulation (DBS) programming relies on selecting electrode contacts that maximize clinical benefit while minimizing side effects. The therapeutic window (range of current yielding symptom improvement without adverse effects) is a key criterion in this decisio...

Attribution assignment for deep-generative sequence models enables interpretability analysis using positive-only data

Generative machine learning models offer a powerful framework for therapeutic design, by efficiently exploring large spaces of biological sequences enriched for desirable properties. Unlike supervised learning methods, which require both positive and negative labeled data, genera...

MRI Characteristics of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Importance Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a demyelinating disease distinct from multiple sclerosis (MS) and aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD). Magnetic resonance imaging (MRI) is central t...

Prehospital Stroke Treatment Trials in Conventional EMS Settings: An Expert Consensus Statement on Operational, Ethical, and Technological Priorities

Prehospital stroke trials enable assessments of ultraearly administration of treatments and management strategies, but face unique challenges in their design, conduct, and analysis. We outline important considerations and recommendations for planning prehospital stroke trials, fo...

Robotic versus open mesh-enforced retrorectus ventral hernia repair: a multi-center comparative study

Abstract Mesh-enforced open ventral hernia repair (OVHR) is associated with increased surgical site occurrences and prolonged hospital stay. Robotic-assisted ventral hernia repair (RVHR) may offer benefits compared to OVHR, but comparative literature is scarce. This multicenter p...

Systematic mapping of bacteriophage gene essentiality with HIDEN-SEQ

Abstract The arms race of bacteriophages and their bacterial hosts has inspired major breakthroughs in biotechnology and shaped phages as fierce predators with great clinical potential to fight multidrug-resistant bacterial pathogens. However, the large amount of genes of unknown...

The liver niche accelerates, while the lung niche restrains secondary spread of breast cancer

Breast cancer progression to visceral organs such as the lung and liver is associated with poor prognosis. Yet, these organs have diverse cellular microenvironments that may differentially influence cancer cell behavior. Here, we show that breast cancer metastases differ in their...

High-density mapping of his-ventricular intervals: impact of recording site and sex-specific differences

Abstract Background Accurate assessment of the His–ventricular (HV) interval is essential to diagnosing infranodal conduction disease, but the influence of recording site and sex on HV values is not well defined. Objective To evaluate the impact of measurement location and sex on...