University Hospital Carl Gustav Carus

Multiple discrimination at work and depressive symptoms in young adults

BACKGROUND: We aimed to estimate the implications of cumulative exposure to discrimination at work for mental health among young adults. Our specific objective was to investigate if experiencing multiple types of discrimination at work is associated with depressive symptoms. METH...

Durable treatment response to Trastuzumab deruxtecan in two patients with recurrent grade III anaplastic ependymoma

Abstract Background Anaplastic ependymoma is a rare and aggressive central nervous system malignancy for which effective systemic treatment options are limited. Trastuzumab deruxtecan (T-DXd), an antibody–drug conjugate targeting human epidermal growth factor receptor 2 (HER2), h...

Pre-ECMO characteristics, organ dysfunction and exploratory mortality prediction in COVID-19 versus non-COVID-19 ARDS treated with veno-venous ECMO: a retrospective cohort study

Abstract Objective The transferability of pre-ECMO characteristics and established mortality prediction tools across COVID-19 (C-19) and non-COVID-19 (nC-19) acute respiratory distress syndrome (ARDS) remains uncertain. We compared clinical characteristics, organ dysfunction, res...

Intraoperative ventilation settings in Germany: an observational multicentre cross-sectional study

Intraoperative lung protective ventilation and, in inhalational anesthesia, minimal fresh gas flow (FGF) are recommended. It remains unclear how these recommendations are transferred to clinical routine. We aimed to assess corresponding anesthesia practices in Germany and raise a...

Distinct Plasma Proteomic Signatures Distinguish MASLD From Non‐Steatotic Individuals but Not From MetALD

ABSTRACT Background and Aims Metabolic dysfunction associated steatotic liver disease (MASLD) is the most prevalent liver disease, yet accurate early detection remains challenging. A particular diagnostic obstacle is distinguishing MASLD from metabolic dysfunction and alcohol‐rel...

Lithium chloride in vitro treatment shows potential to rescue the neuronal phenotype caused by WDFY3 haploinsufficiency

We provide a comprehensive phenotypic characterization of loss-of-function (LoF) variants in WDFY3 based on the largest cohort reported to date (n = 32). Our findings define a monogenic disorder marked by neuropsychiatric features (including autism and ADHD), mild to moderate neu...

Green space exposure predicts manic episodes in bipolar disorder: one year longitudinal analysis using smartphone-derived GPS data

Abstract Urban living is linked to increased psychiatric morbidity, while green spaces may protect mental health via stress-buffering effects. Yet, the role of green space exposure in the onset of affective episodes in bipolar disorder (BD) remains unclear. Using 12 months of GPS...

Clinical Improvement, No Improvement, and Worsening at 24 Hours Following Reperfusion in Patients With Stroke due to Large-Vessel Occlusion

BACKGROUND: Restoring blood flow to ischemic tissue is the cornerstone of acute stroke therapy and is usually beneficial. However, when reperfusion is achieved for severely injured tissue, it is often futile and may occasionally cause harm. We aim to determine the prevalence and...

Tolerance of uncertainty and reflection ability among medical students in Germany

Abstract Background With growing recognition of uncertainty tolerance (UT) and reflection ability (RA) as core competencies for healthcare professionals, targeted promotion of these skills has become increasingly important in medical education. However, research on the associatio...

Early liver parameter increase after transjugular intrahepatic portosystemic shunt (TIPS): hepatic vascular risk factors and development of an exploratory prediction model

Abstract Purpose To investigate early laboratory changes following Transjugular Intrahepatic Portosystemic Shunt (TIPS) and their associations with hepatic vessel diameters. Additionally, to develop a model to predict patients at high-risk for excessive liver parameter increase....

The German S3-level guideline for the diagnosis and management of rare dental disorders

Abstract Objectives The aim of this German S3-level guideline project was to develop evidence-based recommendations to support professionals in the diagnosis and management of individuals with rare dental disorders. The research question was which form of dental care should be pa...

Real-world use of bempedoic acid for hypercholesterolaemia: a German multicentre, retrospective, cohort study

Abstract Background Dyslipidaemia remains a leading cause of death in Germany despite an improving therapeutic landscape, with many patients not achieving guideline-recommended low-density lipoprotein cholesterol (LDL-C) goals. Bempedoic acid, an adenosine triphosphate citrate ly...

Utilization of Carbon Fiber Spinal Instrumentation in Primary Spinal Tumors: Outcome Analysis from the AO Spine Primary Tumor Research and Outcomes Network

Background The use of carbon fiber-reinforced polyetheretherketone (CFR-PEEK) instrumentation in spinal surgery has emerged as an alternative to traditional titanium-based implants in recent years. This study aims to evaluate the use and performance of carbon fiber instrumentatio...

Parvovirus B19 infections in paediatric sickle cell disease patients: Genotype and hydroxyurea treatment influence disease severity

Summary In patients with sickle cell disease (SCD), parvovirus B19 infection (B19V) leads to acute anaemia (aplastic crisis), but may also be associated with other serious complications. We retrospectively analysed clinical data from paediatric SCD patients with B19V infections b...

Combining Small Aperture Approach and Toric Correction for Irregular Astigmatism Management

Purpose: Irregular astigmatism poses a challenge in cataract surgery due to its complex geometry and associated higher-order aberrations (HOAs), which limit the efficacy of conventional toric intraocular lenses (IOLs). IOLs featuring a small-aperture have shown promise in managin...

Anodal Transcranial Direct Current Stimulation Improves Social Behavior Alongside Neuroplastic Changes in a Tsc2 +/− Rat Model of Autism Spectrum Disorder

ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by altered synaptic connectivity and network organization, resulting in profound impairments in social communication and interaction. Transcranial direct current stimulation (tDCS) represents a...

Minigene-based characterization and classification of splice-associated variants in succinate dehydrogenase B

Abstract Pathogenic germline variants in SDHB are associated with an increased risk for tumors such as pheochromocytoma and paraganglioma. However, limited functional evidence for rare variants poses a major challenge for clinical decision making. To systematically investigate po...

Olfactory Threshold Can Be Reliably Tested With Sniffin' Sticks in Non‐Clinical Settings: Associations Shown in a Diverse, General Population

ABSTRACT Objective The olfactory threshold part of the Sniffin' Sticks test is widely used to assess chemosensory function, yet most studies are conducted in controlled laboratory or clinical environments with selective samples. This study examined odour threshold performance wit...

Therapeutic coma in non-convulsive status epilepticus is associated with increased complications and mortality: a retrospective cohort study

INTRODUCTION: While therapeutic coma is an established escalation strategy in generalized convulsive status epilepticus, evidence for benefit in non-convulsive status epilepticus (NCSE) is limited and treatment-related complications may affect outcome. METHODS: We performed a ret...

A pancreatic cancer organoid-macrophage co-culture using starPEG-heparin hydrogel deciphers tumor-immune cell interactions

Abstract Macrophages are among the most abundant immune cells in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) and play a key role in regulating the immunosuppressive niche that facilitates tumor growth. Although recent three-dimensional (3D) culture sy...