University Hospital Bonn

Cross-sectional serological evidence of Brucella spp. exposure in dogs and occupationally exposed humans in Ghana: implications for a one health approach

Brucellosis is a zoonotic disease of public health concern in Sub-Saharan Africa, including Ghana, where it is reported in livestock. Research on canine brucellosis in Ghana is limited. Due to the risk of Brucella spp. infection via the contact of human beings with dogs and dog r...

Ablation of AV Nodal Reentrant Tachycardia in Octogenarians: Safety and Efficacy in a Large Comprehensive Single‐Center Analysis

ABSTRACT Introduction Atrioventricular nodal reentrant tachycardia (AVNRT) is the most common supraventricular tachycardia and is generally considered benign, with excellent outcomes following catheter ablation. However, data on procedural safety and efficacy in very elderly pati...

Clinical outcomes of the PAUL ® glaucoma implant for secondary glaucoma

Abstract Purpose Secondary glaucoma encompasses a broad spectrum of disease entities arising from diverse ocular pathologies and is often refractory to conventional treatment. Glaucoma drainage devices (GDDs) have therefore become an important surgical option. This study evaluate...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

Smartphone-Based Automated Quantification of Bulbar Conjunctival Hyperemia Using Vessel Density Mapping

Purpose: To develop a smartphone application (Conjunctiva VD) that objectively quantifies bulbar conjunctival hyperemia by estimating the conjunctival vessel density (VD) within a user-defined region of interest (ROI). Methods: A total of 100 conjunctival images from 2 public dat...

Substance use and co-occurring mental health conditions among adolescents and young adults in North America: a systematic review

Abstract Background Substance use and co-occurring mental health conditions are common among adolescents and young adults and represent an important clinical and public health concern in North America. Trauma exposure, psychiatric symptoms, and social adversity frequently co-occu...

NLRP3 Regulation in Neonatal Hypoxic–Ischemic Encephalopathy—Focus on Microglial Activation

Neonatal hypoxic–ischaemic encephalopathy (HIE) is a major cause of neonatal mortality and long-term neurological disability, affecting 1–3 per 1000 live births in developed countries and occurring at substantially higher rates in developing countries. Neuroinflammation is a key...

Dystonia 3×3: A Training Guideline for Beginners in Botulinum Neurotoxin Treatment of Cervical Dystonia

Cervical dystonia (CD) is a hyperkinetic movement disorder characterized by involuntary muscle contractions leading to abnormal postures of the head and neck. The injection of botulinum neurotoxin type A (BoNT-A) into the muscles involved is the treatment of choice for CD. BoNT-A...

Automated segmentation and length measurement of metacarpal and phalangeal bones for hand radiograph evaluation

Abstract Evaluating hand and wrist radiographs is essential in pediatric endocrinology and clinical genetics, particularly for the assessment of suspected skeletal anomalies. In this study, we present Auto-Bone-Caliper, an automated system for the segmentation and length measurem...

Tricuspid-Valve Intervention in Heart Failure

BackgroundThe effect of transcatheter tricuspid-valve repair on clinical outcomes, including death and hospitalization for heart failure, in patients with severe tricuspid regurgitation remains uncertain. MethodsWe randomly assigned patients with symptomatic severe tricuspid regu...

High-grade serous ovarian cancer is associated with increased TP53 mutation burden in uterine lavage

High grade serous ovarian cancer (HGSC) has low survival partly due to the lack of methods for detection, diagnosis, and risk prediction. TP53 mutations, which drive HGSC, are found in gynecological tissues as the result of somatic evolution, but it is unknown whether an excess o...

Nanobodies specific for Vβ11 enable detection and noninvasive imaging of antigen-specific T cells in vivo

Through screening of a VHH phage display library constructed from an alpaca immunized with the recombinantly expressed murine myelin oligodendrocyte (MOG)-specific 2D2 T cell receptor (TCR), we identified nanobodies that reduced antigen-driven 2D2 T cell activation in vitro. Immu...

Algorithm Aversion Towards AI-Generated Multiple-Choice Questions

Abstract Algorithm aversion and anti-AI bias describe the human tendency to evaluate decisions made by human agents more favorably than those made by artificial intelligence (AI) algorithms. This study aimed to examine whether algorithm aversion influences students’ evaluations o...

Evidence-based recommendations for advancing the chronic pelvic pain syndrome management by the paradigm change from reactive symptom suppression to proactive 3PM-guided patient-centered care

Abstract Chronic pelvic pain syndrome (CPPS) encompasses a heterogeneous group of debilitating conditions including interstitial cystitis/bladder pain syndrome (IC/BPS), chronic abacterial prostatitis, endometriosis, and pelvic congestion syndrome, among others. Despite advances...

MEmilio: a high performance Modular EpideMIcs simuLatIOn software for multi-scale and comparative simulations of infectious disease dynamics

Abstract Epidemic and pandemic preparedness with rapid outbreak response rely on timely, trustworthy evidence. Mathematical models are crucial for supporting timely and reliable evidence generation for public health decision-making with models spanning approaches from compartment...

How “Micro” Is Microperimetry? Characterizing the Effect of Fundus Tracking on the Psychometric Function

Purpose: The purpose of this study was to quantify whether fundus tracking in microperimetry improves psychometric parameter estimation (as an in vivo demonstration of improved stimulus-delivery precision), and to derive a psychometrically grounded criterion intensity for suprath...

Phylogenomics and antimicrobial resistance genes of invasive non-typhoidal Salmonella in the Ashanti region of Ghana

Abstract Background Invasive non-typhoidal Salmonella (iNTS) disease is a major public health threat in developing countries, yet molecular epidemiological data from Ghana remain limited. This study characterizes the phylogenomic profiles and antimicrobial resistance determinants...

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy

Abstract Objective The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome‐wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS....

How age and sex interaction is associated with immune aging with implications for vaccines and age-related autoimmunity

Immunosenescence is not a uniform decline but a trajectory shaped jointly by age and sex. Using continuous high-dimensional immunophenotyping, we show that aging T cells accumulate a senescent signature of CD28 loss and CD57 gain, and that males reach an inverted CD4:CD8 ratio ea...

Global Real‐World Outcomes of Olaparib in Metastatic Castration‐Resistant Prostate Cancer Patients With Homologous Recombination Repair Alterations

Evidence to guide the treatment for patients with metastatic castration-resistant prostate cancer (mCRPC) and Homologous Recombination Repair (HRR) gene alterations outside of clinical trials remains limited. This was an observational, cohort study, including mCRPC patients with...