University at Buffalo, State University of New York

“I never thought to bring them up to the doctor”: examining symptom appraisal, help-seeking behaviors, and diagnostic delays among young adults with cancer

Abstract Purpose Cancer incidence is rising among young adults (20–39 years), and it is one of the top five causes of death for this age group. Young adults often experience longer delays in diagnosis than children and older adults, which negatively impacts survival and quality o...

Effect of corn syrup consumption on bone and inflammatory parameters in rats with spontaneous periodontitis

Abstract Background Although added sugar consumption is associated with altered periodontal parameters in humans and alveolar bone loss in rodents, the immunoinflammatory pathways involved and the links between local periodontal and systemic effects are not yet defined. The purpo...

Engineering a biomimetic multiphasic suture anchor system for enhanced rotator cuff enthesis regeneration

Abstract Conventional suture anchor methods in rotator cuff repair often fail to replicate the native tendon-to-bone interface, leading to re-tears due to stress concentrations and poor biological integration at anchor sites. To address these challenges, we engineered a biomimeti...

Examining the relationship between D3Cr muscle mass, physical performance, and functional limitation in postmenopausal women

BACKGROUND: The D3-creatine (D3Cr) dilution method provides a non-invasive and accurate assessment of muscle mass. Our objective was to examine the relationship between D3Cr muscle mass, objective measures of physical performance, and self-report physical function postmenopausal...

Racial negligence, transit, and placemaking: An examination of planning practices

Transportation infrastructure is a core component of the built environment that significantly impacts how residents access services, amenities, jobs, education, and recreation. While other facets of urban studies have begun to reckon with the wicked legacy of racialized infrastru...

Study protocol for first national vasa previa perinatal registry

Vasa previa is a rare but potentially catastrophic obstetric condition characterized by unprotected fetal blood vessels over or adjacent to the internal cervical os. Although advances in prenatal ultrasound have dramatically improved neonatal survival through planned cesarean del...

Programmable Property-Based Testing

Property-based testing (PBT) is a popular technique for establishing confidence in software, where users write properties---i.e. executable specifications--that can be checked many times in a loop by a testing framework. In modern PBT frameworks, properties are usually written in...

Empowering PolymericMaterials Discovery by ArtificialIntelligence

Abstract Polymeric materials underpin modern technologies spanning energy storage, microelectronics, healthcare and sustainable manufacturing. Yet their rational design remains exceptionally challenging because material performance emerges from complex interactions among molecula...

Building a Physics-Aware AI Ecosystem for Solid-State Hydrogen Storage Materials

Abstract Hydrogen storage remains a central bottleneck for scalable hydrogen energy systems due to the multiscale and coupled nature of the thermodynamics, kinetics, and microstructural evolution of hydrogen storage materials (HSMs). Although artificial intelligence (AI) has acce...

Raman spectroscopic identification of biochemical alterations in Alzheimer’s disease brain tissue

<title>Abstract</title> Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by chronic inflammation, neuronal loss, and continuous decline in memory and cognitive function. Raman Spectroscopy (RS) offers a powerful, label‑free approach for detecting early...

Slt2 kinase of the cell wall integrity pathway is required for Fks2-specific echinocandin resistance in Candida glabrata

ABSTRACT Candida glabrata is an opportunistic yeast that causes invasive infections in immunocompromised individuals. Echinocandin antifungals are first-line agents in the treatment of invasive candidiasis and act by inhibiting fungal cell wall synthesis by targeting β-1,3-glucan...

Safety and Tolerability of Chronic Carvedilol in Pediatric Dilated Cardiomyopathy: A Report from the Pediatric Cardiomyopathy Registry

Long-term studies on safety of beta-blockers in pediatric heart failure (HF) are scant. We describe the safety profile, dose ranges, and tolerability of carvedilol in pediatric dilated cardiomyopathy (DCM). The Pediatric Cardiomyopathy Registry (PCMR) was used to identify patient...

Robust Inference With Ghostknockoffs in Genome‐Wide Association Studies With Sample Relatedness

ABSTRACT Genome‐wide association studies (GWASs) have been extensively adopted to depict the underlying genetic architecture of complex traits. Recent studies show that knockoff‐based methods can identify variants with unique, potentially causal effects on phenotypes. However, th...

Reporting Revitalization: Local Newspaper Portrayals of Economic Change in a Small Rustbelt City

This research explores how news media narrate urban economic development. Drawing on growth machine theory, I analyze 51 local newspaper stories (2010–2021) within the context of official city council meeting minutes and plans (2008–2017). I find that the newspaper promoted an id...

Early versus late JAK-STAT–IFN signaling distinguishes no rejection from subclinical to clinical TCMR after liver transplantation

Subclinical rejection after liver transplantation precludes immunosuppression withdrawal despite normal clinical function. To better understand the immunobiology of early subclinical rejection, we performed longitudinal, multimodal immune profiling and single-cell RNA sequencing...

Mediating Factors That Explain the Link Between Exposure to Alcohol Content on Social Media and Alcohol Use: A Systematic Review and Meta-Analysis

Despite evidence that there is a link between exposure to alcohol-related content on social media and alcohol use, there has been less focus on testing the underlying mechanisms that explain the link. Findings from the primary studies that test the mechanisms are fragmented and i...

Reduced expression of Brain Expressed X-linked genes in Alzheimer's disease

Background Altered expression of Brain Expressed X-linked (BEX) genes has been implicated in Alzheimer's disease (AD) with inconsistencies and a lack of experimental confirmation. Objective This study aims to characterize BEX expression patterns, examine the association of their...

Computational analysis of a high-density electrode to scale the electric field geometry and intensity for neurostimulation

High-density grid electrodes can be configured to spatially scale the neurostimulation fields and enable the control of depth, intensity, and stimulation vectoring. In this study, we computationally analyze a high-density cluster electrode (HDCE) technology to measure its scalabi...

Outcomes of a Novel Full-Service, Free Ophthalmology Clinic-Within-A-Clinic: A Four-Year Longitudinal Study.

PURPOSE: We evaluate the Clínica Esperanza Ophthalmology Service, a free service for uninsured patients in southern New England. METHODS: The service operates monthly under a novel clinic-within-a-clinic model, existing as a subsidiary of a local free clinic. A mixed-methods prog...

The elusive link: EBV in MS

Introduction The link between the risk of developing Multiple Sclerosis (MS) and Epstein-Barr Virus (EBV) infection has been confirmed. However, the mechanisms by which EBV influences MS remain unclear, likely due to the complex interplay among the EBV subtype, the host’s immune...